Reference-free measurements of the 1s2s2p 2 P1/2,3/2o →1s22s 2S1/2 and 1s2s2p 4P5/2→1s22s 2S1/2 transition energies and widths in lithiumlike sulfur and argon ions

PEstOE/FIS/UI0303/2011 PTDC/FIS/117606/2010 PTDC/FIS-AQM/31969/2017 UID/FIS/04559/2019 SFRH/BD/52332/2013 Contract No. EMMI HA-216 Hubert Curien PESSOA 38028UD PAUILF 2017-C08 Grant No. 01 3 0002 Grant No. ANR-06-BLAN-0223 Grant No. 70NANB15H051We have measured the widths and energies of the 1s2s2p2P1/2,3/2→1s22s2S1/2 transitions in lithiumlike sulfur and argon, as well as the energies of the forbidden 1s2s2p4P5/2→1s22s2S1/2 M2 transition in both elements. All measurements were performed with a double-flat-crystal spectrometer without the use of any reference line. The transition energy measurements have accuracies ranging from 2.3 to 6.4 ppm depending on the element and line intensity. The widths and the intensity ratios of the 1s2s2p2P1/2,3/2→1s22s2S1/2 lines have also been measured. These are reference-free measurements of transitions in core-excited lithiumlike ions and have an accuracy comparable to the best relative measurements. We have also performed multiconfiguration Dirac-Fock calculations of the widths, energies, and intensity ratios. An extensive comparison between existing experimental results and theory is performed, and Bayesian techniques are employed to extract the energy of the 1s2p24P1/2→1s22p2P1/2 transition in sulfur and identify contaminant transitions.publishersversionpublishe

Reference-free measurements of the 1s 2s 2p 2PO1=2;3=2 ! 1s2 2s 2S1=2 and 1s 2s 2p 4P5=2 ! 1s2 2s 2S1=2 transition energies and widths in lithiumlike sulfur and argon ions

We have measured the widths and energies of the 1s2s2p 2 P 1/2,3/2 → 1s 2 2s 2 S 1/2 transitions in lithiumlike sulfur and argon, as well as the energies of the forbidden 1s2s2p 4 P 5/2 → 1s 2 2s 2 S 1/2 M2 transition in both elements. All measurements were performed with a double-flat crystal spectrometer without the use of any reference line. The transition energy measurements have accuracies ranging from 2.3 ppm to 6.4 ppm depending on the element and line intensity. The widths and the intensity ratios of the 1s2s2p 2 P 1/2,3/2 → 1s 2 2s 2 S 1/2 lines have also been measured. These are the first reference-free measurements of transitions in core-excited lithiumlike ions, and have an accuracy comparable to the best relative measurements. We have also performed multi-configuration Dirac-Fock calculations of the widths, energies and intensity ratios. Extensive comparison between existing experimental results and theory is performed, and Bayesian techniques employed to extract the energy of the 1s 2p 2 4 P 1/2 → 1s 2 2p 2 P 1/2 transition in sulfur and identify contaminant transitions

Absolute Energy Measurements with Superconducting Transition-Edge Sensors for Muonic X-ray Spectroscopy at 44 keV

Superconducting transition-edge sensor (TES) microcalorimeters have great utility in x-ray applications owing to their high energy resolution, good collecting efficiency and the feasibility of being multiplexed into large arrays. In this work, we develop hard x-ray TESs to measure the absolute energies of muonic-argon ($\mu$-Ar) transition lines around 44 keV and 20 keV. TESs with sidecar absorbers of different heat capacities were fabricated and characterized for their energy resolution and calibration uncertainty. We achieved ~ 1 eV absolute energy measurement accuracy at 44 keV, and < 12 eV energy resolution at 17.5 keV

Mudskipper genomes provide insights into the terrestrial adaptation of amphibious fishes

Mudskippers are amphibious fishes that have developed morphological and physiological adaptations to match their unique lifestyles. Here we perform whole-genome sequencing of four representative mudskippers to elucidate the molecular mechanisms underlying these adaptations. We discover an expansion of innate immune system genes in the mudskippers that may provide defence against terrestrial pathogens. Several genes of the ammonia excretion pathway in the gills have experienced positive selection, suggesting their important roles in mudskippers’ tolerance to environmental ammonia. Some vision-related genes are differentially lost or mutated, illustrating genomic changes associated with aerial vision. Transcriptomic analyses of mudskippers exposed to air highlight regulatory pathways that are up- or down-regulated in response to hypoxia. The present study provides a valuable resource for understanding the molecular mechanisms underlying water-to-land transition of vertebrates

Quantum Electrodynamic and nuclear effects in Li-like ions and muonic atoms

Nous avons effectué des calculs Dirac-Fock multi-configuration des énergies de transitions de structure fine 1s²2p²PJ-1s²2s²S1/2, J=1/2, 3/2, les transitions à partir d'états excités en couche internes 1s2s2p²PJ-1s²2s²S1/2, J=1/2, 3/2 et 1s2s2p4PJ-1s²2s²S1/2, J=1/2, 3/2, 5/2, et les transitions Auger à partir de ces mêmes états 1s2s2p4PJ- 1s2 1S0, J=1/2, 3/2 dans la séquence isoélectronique du lithium, pour des ions de numéro atomique 10 ≤ Z ≤ 96. Des corrections électrodynamiques quantiques avec modèle d'opérateur efficace et des corrections de corrélation électronique sont incluses dans les fonctions d'onde de Dirac avec une taille nucléaire finie. Des corrections de polarisation de Breit et de polarisation du vide de tous les ordres sont également incluses dans le calcul, avec une fonction d'onde d'ensemble actif entièrement optimisée. Des comparaisons approfondies entre les résultats théoriques existants et l'expérience sont effectuées. Nous évaluons également les paramètres nucléaires qui minimisent l'écart pondéré entre la théorie et l'expérience dans les modèles muoniques 208Pb avec des modèles Fermi à deux paramètres et Gauss à trois paramètres. Nous avons obtenu r = 5.5057 fm dans le modèle de Fermi et r = 5.5031 dans le modèle de Gauss par ajustement polynomial. Nous analysons également les contributions individuelles de 226Ra et 248Cm muoniques en utilisant la même prescription de corrections exactes de QED pour les expériences à venir.We have performed multi-configuration Dirac-Fock calculations of the transition energies in the transitions of 1s²2p²PJ-1s²2s²S1/2, J=1/2, 3/2, core-excited transitions of 1s2s2p²PJ-1s²2s²S1/2, J=1/2, 3/2 and 1s2s2p4PJ-1s²2s²S1/2, J=1/2, 3/2, 5/2, and Auger transition energies of 1s2s2p2PJ-1s2 1S0 and 1s2s2p4PJ- 1s2 1S0, J=1/2,3/2 in the lithium isoelectronic sequence for low- to high-Z ions (Z=10-96). Quantum-electrodynamic corrections with effective operator model and electronic correlation corrections are included in Dirac wave functions with finite nuclear size. All-order Breit and vacuum polarization corrections are also included in the calculation, with a fully optimized active set wavefunction. Extensive comparisons between existing theorical results and experiment are performed. We also evaluate nuclear parameters that minimize the weighted theory-experiment discrepancy in muonic 208Pb with two-parameter Fermi and three-parameter Gauss models. We obtain r=5.5057 fm in the Fermi model and r=5.5031 in Gauss model by polynomial-fitting. We also analyze the individual contributions of muonic 226Ra and 248Cm using the same prescription of exact QED correction for the upcoming experiments

Effets électrodynamiques et nucléaires quantiques dans les ions de type lithium et les atomes muoniques

We have performed multi-configuration Dirac-Fock calculations of the transition energies in the transitions of 1s²2p²PJ-1s²2s²S1/2, J=1/2, 3/2, core-excited transitions of 1s2s2p²PJ-1s²2s²S1/2, J=1/2, 3/2 and 1s2s2p4PJ-1s²2s²S1/2, J=1/2, 3/2, 5/2, and Auger transition energies of 1s2s2p2PJ-1s2 1S0 and 1s2s2p4PJ- 1s2 1S0, J=1/2,3/2 in the lithium isoelectronic sequence for low- to high-Z ions (Z=10-96). Quantum-electrodynamic corrections with effective operator model and electronic correlation corrections are included in Dirac wave functions with finite nuclear size. All-order Breit and vacuum polarization corrections are also included in the calculation, with a fully optimized active set wavefunction. Extensive comparisons between existing theorical results and experiment are performed. We also evaluate nuclear parameters that minimize the weighted theory-experiment discrepancy in muonic 208Pb with two-parameter Fermi and three-parameter Gauss models. We obtain r=5.5057 fm in the Fermi model and r=5.5031 in Gauss model by polynomial-fitting. We also analyze the individual contributions of muonic 226Ra and 248Cm using the same prescription of exact QED correction for the upcoming experiments.Nous avons effectué des calculs Dirac-Fock multi-configuration des énergies de transitions de structure fine 1s²2p²PJ-1s²2s²S1/2, J=1/2, 3/2, les transitions à partir d'états excités en couche internes 1s2s2p²PJ-1s²2s²S1/2, J=1/2, 3/2 et 1s2s2p4PJ-1s²2s²S1/2, J=1/2, 3/2, 5/2, et les transitions Auger à partir de ces mêmes états 1s2s2p4PJ- 1s2 1S0, J=1/2, 3/2 dans la séquence isoélectronique du lithium, pour des ions de numéro atomique 10 ≤ Z ≤ 96. Des corrections électrodynamiques quantiques avec modèle d'opérateur efficace et des corrections de corrélation électronique sont incluses dans les fonctions d'onde de Dirac avec une taille nucléaire finie. Des corrections de polarisation de Breit et de polarisation du vide de tous les ordres sont également incluses dans le calcul, avec une fonction d'onde d'ensemble actif entièrement optimisée. Des comparaisons approfondies entre les résultats théoriques existants et l'expérience sont effectuées. Nous évaluons également les paramètres nucléaires qui minimisent l'écart pondéré entre la théorie et l'expérience dans les modèles muoniques 208Pb avec des modèles Fermi à deux paramètres et Gauss à trois paramètres. Nous avons obtenu r = 5.5057 fm dans le modèle de Fermi et r = 5.5031 dans le modèle de Gauss par ajustement polynomial. Nous analysons également les contributions individuelles de 226Ra et 248Cm muoniques en utilisant la même prescription de corrections exactes de QED pour les expériences à venir

Light-Triggered Specific Cancer Cell Release from Cyclodextrin/Azobenzene and Aptamer-Modified Substrate

Cell adhesion behaviors of stimuli-responsive surfaces have attracted significant attention for their potential biomedical applications. Distinct from temperature and pH stimuli, photoswitching avoids the extra input of thermal energy or chemicals. Herein, we designed a novel reusable cyclodextrin (CD)-modified surface to realize photoswitched specific cell release utilizing host–guest interactions between CD and azobenzene. The azobenzene-grafted specific cell capture agent was assembled onto the CD-modified surface to form a smart surface controlling cell adhesion by light radiation. After UV light irradiation, the azobenzene switched from <i>trans</i>- to <i>cis</i>-isomers, and the <i>cis</i>-azobenzene was not recognized by CD due to the unmatched host–guest pairs; thus, the captured MCF-7 cells could be released. Light-triggered specific cancer cell release with high efficiency may afford a smart surface with significant potential applications for the isolation and analysis of circulating tumor cells

Light-Responsive Janus-Particle-Based Coatings for Cell Capture and Release

A robust light-responsive coating based on Janus composite particles is achieved. First, strawberry-like silica Janus particles are synthesized by the sol–gel process at a patchy emulsion interface. One side of the silica Janus particles possesses nanoscale roughness, and the other side is flat. Then, spiropyran-containing polymer brushes are grafted onto the coarse hemispherical side of the as-synthesized Janus particles, and the other flat side is modified with imidazoline groups. The light-responsive polymer brush-terminated coarse hemispherical sides direct toward the air when the Janus composite particles self-organize into a layer on the surface of epoxy resin substrate. The imidazoline groups react with the epoxy groups in the epoxy resin to form a robust smart coating. The coating can be reversibly triggered between hydrophobic and hydrophilic by UV and visible-light irradiation, which is attributed to the isomerization of spiropyran moieties. When the hydrophobic ring-closed spiropyran form is prominent, HeLa cells can be effectively captured onto the coating. After UV light irradiation, the ring-closed spiropyran form changes to the hydrophilic ring-opened zwitterionic merocyanine form, and then the captured cells are released. This work shows promising potential for engineering advanced smart biointerfaces

The potential of targeting cuproptosis in the treatment of kidney renal clear cell carcinoma

Renal cell carcinoma (RCC) is one of the top ten malignancies and tumor-related causes of death worldwide. The most common histologic subtype is kidney renal clear cell carcinoma (KIRC), accounting for approximately 75% of all RCC cases. Early resection is considered the basic treatment for patients with KIRC. However, approximately 30% of these patients experience recurrence post-operation. Cuproptosis, an autonomous mechanism for controlling cell death, encompasses various molecular mechanisms and multiple cellular metabolic pathways. These pathways mainly include copper metabolic signaling pathways, mitochondrial metabolism signaling pathways, and lipoic acid pathway signaling pathways. Recent evidence shows that cuproptosis is identified as a key cell death modality that plays a meaningful role in tumor progression. However, there is no published systematic review that summarizes the correlation between cuproptosis and KIRC, despite the fact that investigations on cuproptosis and the pathogenesis of KIRC have increased in past years. Researchers have discovered that exogenous copper infusion accelerates the dysfunction of mitochondrial dysfunction and suppresses KIRC cells by inducing cuproptosis. The levels of tricarboxylic acid cycle proteins, lipoic acid protein, copper, and ferredoxin 1 (FDX1) were dysregulated in KIRC cells, and the prognosis of patients with high FDX1 expression is better than that of patients with low expression. Cuproptosis played an indispensable role in the regulation of tumor microenvironment features, tumor progression, and long-term prognosis of KIRC. In this review, we summarized the systemic and cellular metabolic processes of copper and the copper-related signaling pathways, highlighting the potential targets related to cuproptosis for KIRC treatment

VeLoc

We present VeLoc, a smartphone-based vehicle localization approach that tracks the vehicle&apos;s parking location without GPS or WiFi signals. It uses only the embedded accelerometer and gyroscope sensors. VeLoc harnesses constraints imposed by the map and landmarks (e.g., speed bumps) recognized from inertial data, employs a Bayesian filtering framework to estimate the location of the vehicle. We have conducted experiments in three parking structures of different sizes and configurations, using three vehicles and three kinds of driving styles. We find that VeLoc can always localize the vehicle within 10m, which is sufficient for the driver to trigger a honk using the car key. Copyright 2014 ACM.EI