Thrombotic and hemorrhagic complications in idiopathic erythrocytosis

We report clinical features of a large cohort of patients with IE compared to a cohort of patients with PV, focusing on the thrombotic and hemorrhagic risk

A Lightweight and Accurate RNN in Wearable Embedded Systems for Human Activity Recognition

Human activity recognition (HAR) is an important technology for a wide range of applications including elderly people monitoring, ambient assisted living, sport and fitness activities. The aim of this paper is to address the HAR task directly on a wearable device, implementing a recurrent neural network (RNN) on a low cost, low power microcontroller, ensuring the required performance in terms of accuracy and low complexity. To reach this goal we first develop a lightweight RNN on the Human Activity Recognition Using Smartphones dataset in order to accurately detect human activity and then we port the RNN to the embedded device Cloud-JAM L4, based on an STM32 microcontroller. Experimental results show that this HAR RNN-based detector can be effectively implemented on the chosen constrained-resource system, achieving an accuracy of about 90.50% with a very low memory cost (40.883 KB) and inference time (67.131 ms), allowing the design of a wearable embedded system for human activity recognition

Thromboses and hemorrhages are common in MPN patients with high JAK2V617F allele burden

The most common causes of morbidity and mortality in myeloproliferative neoplasms (MPN) are thrombotic and hemorrhagic complications. The JAK2V617F mutation, commonly found in MPN, correlates with several clinical and laboratory characteristics even if the relevance of JAK2V617F allele burden in the natural history of these diseases is unclear. In this study we searched, a relation between thrombotic and hemorrhagic complications and JAK2V617F allele burden level in MPN patients. We evaluated 253 consecutive MPN [121 essential thrombocythemia (ET), 124 polycythemia vera (PV), and 8 primary myelofibrosis (PMF)] patients in whom the JAK2V617F allele burden was available, all studied and followed (median 8.8 years) in our department. Patients were stratified accordingly to their JAK2V617F allele burden, into four quartiles (1st 75%). Significantly higher incidence of thromboses (p = 0.001) and hemorrhages (p < 0.001) during follow-up has been observed in higher quartiles when compared to lower ones. Thrombosis- and hemorrhage-free survivals were poorer in patients belonging to the highest quartile. Our data suggest that MPN patients with JAK2V617F allele burden higher than 75% have to be considered as high risk patients, being prone to develop thrombo-hemorrhagic complications during the disease course

Prevalence and Causes of Anemia in Hospitalized Patients: Impact on Diseases Outcome

Anemia is extremely common in hospitalized patients who are old and often with multiple diseases. We evaluated 435 consecutive patients admitted in the internal medicine department of a hub hospital and 191 (43.9%) of them were anemic. Demographic, historic and clinical data, laboratory tests, duration of hospitalization, re-admission at 30 days and death were recorded. Patients were stratified by age (80 years), anemia severity, and etiology of anemia. The causes of anemia were: iron deficiency in 28 patients, vitamin B12 and folic acid deficiencies in 6, chronic inflammatory diseases in 80, chronic kidney disease in 15, and multifactorial in 62. The severity of the clinical picture at admission was significantly worse (p < 0.001), length of hospitalization was longer (p < 0.001) and inversely correlated to the Hb concentration, re-admissions and deaths were more frequent (p 0.017) in anemic compared to non-anemic patients. A specific treatment for anemia was used in 99 patients (36.6%) (transfusions, erythropoietin, iron, vitamin B12 and/or folic acid). Anemia (and/or its treatment) was red in the discharge letter only 54 patients. Even if anemia is common, in internal medicine departments scarce attention is paid to it, as it is generally considered a "minor" problem, particularly in older patients often affected by multiple pathologies. Our data indicate the need of renewed medical attention to anemia, as it may positively affect the outcome of several concurrent medical conditions and the multidimensional loss of function in older hospitalized patients

Two novel missense mutations in EPOR gene causes erythrocytosis in two unrelated patients

Description of two novel EPOR mutations causing hyperactivity, increase proliferation, and differentation sustaining the erythrocytotic phenotype of the patient