52 research outputs found
Ring-Exchange Interaction Effects on Magnons in Dirac Magnet CoTiO
In magnetically ordered materials with localized electrons, the fundamental
magnetic interactions are due to exchange of electrons [1-3]. Typically, only
the interaction between pairs of electrons' spins is considered to explain the
nature of the ground state and its excitations, whereas three-, four-, and
six-spin interactions are ignored. When these higher order processes occur in a
loop they are called cyclic or ring exchange. The ring-exchange interaction is
required to explain low temperature behavior in bulk and thin films of solid
He [4-8]. It also plays a crucial role in the quantum magnet LaCuO
[9,10]. Here, we use a combination of time domain THz (TDTS) and magneto-Raman
spectroscopies to measure the low energy magnetic excitations in CoTiO, a
proposed Dirac topological magnon material [11,12] where the origin of the
energy gap in the magnon spectrum at the Brillouin zone center remains unclear.
We measured the magnetic field dependence of the energies of the two lowest
energy magnons and determine that the gap opens due to the ring-exchange
interaction between the six spins in a hexagon. This interaction also explains
the selection rules of the THz magnon absorption. Finally, we clarify that
topological surface magnons are not expected in CoTiO. Our study
demonstrates the power of combining TDTS and Raman spectroscopies with theory
to identify the microscopic origins of the magnetic excitations in quantum
magnets.Comment: 7 pages, 4 figures in main text, 26 pages and 11 figures in
supplemen
Monoclonal antibodies biosimilarity assessment using transient isotachophoresis capillary zone electrophoresis-tandem mass spectrometry
Out of all categories, monoclonal antibody (mAb) therapeutics attract the most interest due to their strong therapeutic potency and specificity. Six of the ten top-selling drugs are antibody-based therapeutics that will lose patent protection soon. The European Medicines Agency has pioneered the regulatory framework for approval of biosimilar products and approved the first biosimilar antibodies by the end of 2013. As highly complex glycoproteins with a wide range of micro-variants, mAbs require extensive characterization through multiple analytical methods for structure assessment rendering manufacturing control and biosimilarity studies particularly product and time-consuming. Here, capillary zone electrophoresis coupled to mass spectrometry by a sheathless interface (CESI-MS) was used to characterize marketed reference mAbs and their respective biosimilar candidate simultaneously over different facets of their primary structure. CESI-MS/MS data were compared between approved mAbs and their biosimilar candidates to prove/disconfirm biosimilarity regarding recent regulation directives. Using only a single sample injection of 200 fmol, CESI-MS/MS data enabled 100% amino acids (AA) sequence characterization, which allows a difference of even one AA between two samples to be distinguished precisely. Simultaneously glycoforms were characterized regarding their structures and position through fragmentation spectra and glycoforms semiquantitative analysis was established, showing the capacity of the developed methodology to detect up to 16 different glycans. Other posttranslational modifications hotspots were characterized while their relative occurrence levels were estimated and compared to biosimilars. These results proved the value of using CESI-MS because the separation selectivity and ionization efficiency provided by the system allowed substantial improvement in the characterization workflow robustness and accuracy. Biosimilarity assessment could be performed routinely with a single injection of each candidate enabling improvements in the biosimilar development pipeline
Specifics of the Elemental Excitations in "True One-Dimensional" MoI van der Waals Nanowires
We report on the temperature evolution of the polarization-dependent Raman
spectrum of exfoliated MoI, a van der Waals material with a "true
one-dimensional" crystal structure that can be exfoliated to individual atomic
chains. The temperature evolution of several Raman features reveals anomalous
behavior suggesting a phase transition of a magnetic origin. Theoretical
considerations indicate that MoI is an easy-plane antiferromagnet with
alternating spins along the dimerized chains and with inter-chain helical spin
ordering. The calculated frequencies of the phonons and magnons are consistent
with the interpretation of the experimental Raman data. The obtained results
shed light on the specifics of the phononic and magnonic states in MoI and
provide a strong motivation for future study of this unique material with
potential for spintronic device applications.Comment: 28 page
Cytoreduction (Peritonectomy Procedures) Combined with Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Advanced Ovarian Cancer: Retrospective Italian Multicenter Observational Study of 511 Cases
Comprehensive Data via Spectroscopy and Molecular Dynamics of Chemically Treated Graphene Nanoplatelets
Graphene nanoplatelets (GnPs) are promising candidates for gas sensing applications because they have a high surface area to volume ratio, high conductivity, and a high temperature stability. The information provided in this data article will cover the surface and structural properties of pure and chemically treated GnPs, specifically with carboxyl, ammonia, nitrogen, oxygen, fluorocarbon, and argon. Molecular dynamics and adsorption calculations are provided alongside characterization data, which was performed with Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD) to determine the functional groups present and effects of those groups on the structural and vibrational properties. Certain features in the observed Raman spectra are attributed to the variations in concentration of the chemically treated GnPs. XRD data show smaller crystallite sizes for chemically treated GnPs that agree with images acquired with scanning electron microscopy. A molecular dynamics simulation is also employed to gain a better understanding of the Raman and adsorption properties of pure GnPs
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