The nature of child-adult interaction : from turn-taking to understanding pointing and use of pointing gestures

Analyses of interactions between an adult and a one-year-old child are often connected with studying early communicative competences, e.g. the child’s participation in turn-taking sequences, in joint attention, and use of pointing gestures. Infants’ communicative behaviors were studied using a structured observational measure – the Early Social Communication Scales (Mundy et al., 2003) in a study of 358 12-month-old children. An exploratory factor analysis revealed: (i) a distinction between the categories of initiation and response among the behaviors displayed, (ii) simple and complex behavior categories occurring; (iii) the presence within one factor of behaviors fulfilling various functions (e.g. requesting and sharing interest). An analysis of the results showed that communicative competences can be classified according to their level and ignoring their function, and made it possible to suggest modifications to the way in which behaviors are coded on the ESCS and to complement the procedure of studying early communicative competences

Waiting for a treat : studying behaviors related to self-regulation in 18- and 24- month olds

The ability to delay gratification - conceived as an early expression of self-regulation - develops in the second half of the second year of life. We used inductive methodology to identify different behaviors and set of behaviors performed by children while waiting for a treat. We asked which sets are more effective when it comes to successfully delaying gratification and how all observed sets change during toddler age. 130 children were tested twice - at 18 and at 24 months - using a Snack Delay Task. We observed 20 different behaviors and distinguished 4 sets of behaviors. The most important and effective set for delaying gratification in 18 and in 24 month olds was the set called Attention and Movements. We concluded that growth in the ability to delay gratification resulted from increased ability to overcome temptation by using an active strategy mainly based on attention

Recursion as a common ground of mental, communicative, and linguistic processes

Od kilkunastu lat na łamach zagranicznych czasopism toczy się debata wokół rekursywności ludzkich procesów umysłowych. Jej inicjator i główny propagator terminu "rekursja" (recursion) to Noam Chomsky. Ogranicza on jej występowanie do płaszczyzny ludzkiego języka i przypisuje cechę rekursywności (recursive property) składni tzw. języka umysłu. Wywołało to mocny sprzeciw badaczy upatrujących przejawów rekursji także na innych płaszczyznach ludzkiego funkcjonowania, jak komunikacja, teoria umysłu, składnia dopełnieniowa czy pragmatyka. Tekst przedstawia argumenty przemawiające za możliwością rozpatrywania rekursji jako mechanizmu wspólnego wszystkim wspomnianym płaszczyznom, pod warunkiem przyjęcia rozwojowej perspektywy, uwzględniającej dynamikę i sekwencyjność zachodzących w nich procesów i zmian.For nearly twenty years there has been an ongoing debate in international journals concerning the recursiveness of human mental processes. The main instigator of the debate and at the same time the main exponent of the term "recursion" is Noam Chomsky. According to him, recursion is an exclusive property of the syntax of the so-called "internal language of mind" (I-language). This conclusion has been contested by researchers claiming that recursion can also be observed in: communication, theory of mind, the syntax of complementation, or pragmatics. The article presents some arguments in favor of understanding recursion as a common ground of all the above phenomena as long as they are analyzed from a developmental perspective, with the dynamics and sequentiality of the constantly occurring processes and changes taken into accoun

2D and 3D culture of stem cells

Wstęp i cel: Komórki macierzyste są szeroko stosowane w wielu naukach, szczególnie w chorobach. Dzięki swoim właściwościom proliferacyjnym i zdolności do tworzenia się w innych elementach organizmu zastosowanie w mechanizmie regeneracyjnym, przy zachowaniu charakterystycznych parametrów oparzeń, odbudowie układu krwiotwórczego. później je pozyskać z wielu dzieci m.in. składników tłuszczowej, szpiku kostnego, krwi pępowinowej czy mleka kobiecego.  Obecny stan wiedzy: Dlatego ważne jest, aby wykorzystać metodę hodowli, dzięki której w krótkim czasie możemy uzyskać wyniki badań, które pozwolą wykonać życie i zróżnicowanie się w innych typach. Do hodowli jest uzyskiwana ilość ilości energii, źródło węgla, składniki odżywcze i powietrze. Najpowszechniej jest metodą 2D, która jest dość tania i skuteczna do wykonania. Metoda 3D, choć droższa i wyższa pracochłonna, jest wyższa wydajna. Metodą 3D, czyli sferyczną, mamy możliwość uzyskania środowiska, które zapewnia warunki in vivo, których nie uzyskujemy metodą 2D. Komórki hodowane sferycznie dobrze bodźce ze środowiska w trzech wymiarach, na poziomie komórka-komórka i komórka-macierz zewnątrzkomórkowa.Wykorzystaj dodatkowy przepływ cytokin, składników odżywczych, czynników wzrostu i chemokin. Wnioski: W przyszłości metoda 3D może wyprzeć metody hodowli 2D. Zapewnij warunki zbliżone do tych w wynikach, możemy ocenić wyniki testów analizowanych na zwierzętach. Obecnie w takich kulturach coraz częściej testuje się leki stosowane w onkologii i określa się ich efekt terapeutyczny

SIBO - the present knowledge within the contekst of clinical dependencies and therapy

Introduction: The gut microbiome is an integral part of the body, and the eubiosis conditio significantly  influences homeostasis. Small intestinal bacterial overgrowth (SIBO) is connected with an increased numer of bacteria, it causes gastrointestinal symptoms. The main symptoms are abdominal pain, bloating and diarrhea. SIBO correlates with the occurrence of other chronic diseases. The basis of treatment are antibiotics. There are also scientific reports on supplementing pharmacological therapy with dietary management. Objective: The purpose of this paper is to review the current knowledge on the bacterial overgrowth of the small intestine. Particular attention took notice of to the relationship  between SIBO and other chronic diseases as well as potential and applied treatments. Material and methods: The review includes publications published in 2020-2023 and certain works published earlier, in the years 2008-2017. Data were collected using PubMed, ScienceDirect i Google Scholar. Results: Small intestinal bacterial overgrowth is heterogeneous disorder. Its symptoms are nonspecific. SIBO is related to several different diseases and corresponds with them. Empirical treatment consists in administration of antibiotics. Supplementing therapy with alternative methods for example probiotic and diet therapy  promotes success in treating. Conclusions: The lack of standarized therapeutic menagment and focused on bacterial eradication only approach makes, SIBO is recurrent ailment. More research is needed. The important thing is holistic approach on etiology, pathogenesis and therapy

Clinical manifestations of neuroborreliosis in children – review of literature

Introduction: The most common tick-borne disease caused by the spirochete Borrelia burgdorferi is Lyme disease. It is characterized by a variety of disorders: dermatological, rheumatological, cardiological and neurological. Neuroborreliosis is defined as an involvement of the nervous system, and it is the second most common form of infection in children (10-15% of those infected). The aim of the study: To review the available materials and presentation of the current state of knowledge on the various manifestations of neuroborreliosis in children. Material and method: Databases such as PubMed and Google Scholar were searched. Literature was searched using the keywords: Lyme disease, neuroborreliosis, borreliosis, facial nerve paralysis, and pediatric population. The materials obtained in this way were analyzed in terms of compliance with the subject of the work. Results: Typical clinical manifestations of neuroborreliosis in children are facial nerve palsy and meningitis. Neuroborreliosis is the cause of 50% of all cases of bilateral facial nerve palsy in children. Multiple cranial and peripheral neuritis, myelitis, cerebral vasculitis and, consequently, the formation of intracranial aneurysms are less common manifestations of infection. Conclusions: The symptoms of neuroborreliosis are non-specific. This makes it difficult to make an accurate diagnosis. Even if no information on tick bite or erythema migrans has been obtained from the clinical history, neuroborreliosis should be considered in the differential diagnosis, especially in Lyme-endemic areas

CRP – a valuable source of information or just a laboratory test?

Background and Purpose: Laboratory tests are an inseparable element in modern medicine. They provide us with valuable clues for making a diagnosis or monitoring treatment. One of the most frequently ordered biochemical tests is the determination of the level of CRP in the blood. The aim of the study is to present the clinical usefulness of this study and to present knowledge about C-reactive protein.   Current state of knowledge: It is produced mainly by the liver, but the latest reports confirm local synthesis, among others, in arterial endothelial cells. The most common reason for the increase in the level of CRP is the appearance of infection, during which time its concentration may increase by up to 1000 times. Elderly patients have a weaker immune system response than younger patients, therefore the rise in CRP may be less pronounced. Other reasons are autoimmune diseases, cancer, or acute or chronic inflammation. As a result of cel damage, pro-inflammatory cytokines are secreted, which stimulate the production of CRP. Most scientific sources consider CRP ≥ 10 mg/L to be significant. Values of 3-10mg/L are considered a slight increase in CRP levels. Such CRP values were found in about 1/3 of the American population. Conclusions:  The CRP level should not be interpreted as an isolated medical parameter, but in conjunction with other tests and the patient's current state of health. Based on the amount of CRP in the blood and changes in its concentration over time, we can check the response to treatment and predict the course of some diseases

Emotional and attentional predictors of self-regulation in early childhood

The development of self-regulation in early childhood is related to development of emotional regulation and attention, in particular executive attention (Feldman, 2009; Posner & Rothbart, 1998). As the ability to self-regulate is crucial in life (Casey et al., 2011), it is important to reveal early predictors of self-regulation. The aim of the paper is to present the results of longitudinal studies on the relationships between the functioning of attention, regulation of emotion and later self-regulatory abilities. 310 children were assessed at three time points. At 12 months of age emotional regulation in situation of frustration and attention regulation were assessed. At 18 and 24 months behavioral-emotional regulation in the Snack Delay Task was measured. Additionally parents assessed executive attention using The Early Childhood Behavior Questionnaire when children were 26 months old. Structural equation modelling revealed two different paths to development of self-regulatory abilities at 18 months: emotional (reactive system) and emotionalattentional and only one emotional-attentional path at 24 months. The early ability to focus attention and later executive attention functioning revealed to be important predictors of self-regulatory abilities both at 18 and 24 months of age

Teplizumab - current state of knowledge on the effects of teplizumab in preventing the development of type 1 diabetes in people at risk

Background and Purpose: Type 1 diabetes is a chronic autoimmune disease from the group of metabolic disorders, where the immune system attacks and destroys the insulin producing cells of the pancreas, leading to hyperglycemia and the need for lifelong exogenous insulin supplementation. This results in increased morbidity, life threatening complications, shortened lifespan and quality of life. So there is an urgent need to develop prevention and treatment for people at risk of developing type 1 diabetes. Current state of knowledge: Recently, there has been significant progress in the field of immunotherapy with therapeutic strategies that focus on stopping the disease in the presymptomatic stage by preserving residual beta-cell function. Randomized, double-blind clinical trials of teplizumab were conducted in relatives of patients with established type 1 diabetes who had not yet been diagnosed with the disease, but were at high risk of developing clinical disease, based on these studies The FDA has approved teplizumab, under trade name Tzield, as a treatment to delay the onset of type 1 diabetes. Conclusion: The reviewed research papers present strong evidence that teplizumab halts the severe decline in beta cells and possibly improves their function after treatment in a high-risk population. In addition, the effect persists

Revealing infant communicative competencies : Early Social Communication Scale as an example of the measurement instrument

The aim of the present analysis is to describe the developmental trajectory of the infant and toddler communicative competencies. Turn-taking, gaze-following, joint attention and pointing gestures are the most important expressions of these competencies that could be measured by the Early Social Communication Scale (ESCS Mundy et al., 2003). We present the results of a research conducted with 358 one-year old children and obtained through the Polish version of this scale (ESCS). The validity and reliability of the Polish version of ESCS proved to be satisfactory. The obtained results were analyzed emphasizing the role of early communicative competencies in the further social, linguistic and cognitive development of a child and indicating the domain of psychological practice where ESCS could be implemented