Tertiary amine effect: synthesis of some novel spirosubstituted pyrido[2,3-d]pyrimidines

5-Formyl-6-tertiaryamino uracils 3 prepared from 6-chloro-5-formyl uracil derivative 1 react with barbituric acids 4 in the presence of base catalyst to afford a novel class of spirosubstituted pyrido[2,3- d]pyrimidines 5 via 1,6-electro-cyclisation in excellent yields

Synthesis of some complex pyrano[2,3-b]- and pyrido[2,3-b]quinolines from simple acetanilides via intramolecular domino hetero Diels–Alder reactions of 1-oxa-1,3-butadienes in aqueous medium

Some complex pyrano[2,3-b]- and pyrido[2,3-b]quinolines were synthesized from simple acetanilides via intramolecular domino hetero Diels–Alder reactions of 1-oxa-1,3-butadienes using water as solvent

Synthesis of novel classes of Pyrido[2,3-d]-pyrimidines, pyrano[2,3-d]pyrimidines, and pteridines

6-Amino-5-formyluracils 1 and 5-formyl-6-hydroxyuracils 4 react with Meldrum 19sacid2inthepresenceofpiperidineascatalystunderthermolyticconditions to afford 6-carboxy-2,4,7-trioxopyrido[2,3-d]pyrimidines 3 and 6-carboxy-2,4,7trioxopyrano[2,3-d]pyrimidines 5 in good yield. Under identical conditions, 6-amino5-nitrosouracils 6 react with 2 to afford pteridine-6-carboxylic acids 7 in good yields

Water-Promoted Synthesis of 3,3'- Di(indolyl)oxindoles

The reaction of isatin and indoles in refluxing water/ethanol (7:3) affords 3,3'- di(indolyl)oxindoles in excellent yields

Uncatalyzed Michael addition of indoles: synthesis of some novel 3-alkylated indoles via a three-component reaction in solvent-free conditions

—Synthesis of some novel 3-alkylated indoles via an uncatalyzed Michael addition of indoles using three components in one-pot solvent-free conditions is reported. The mechanism was established by performing the reaction in two steps. The reaction was also studied in different solvents and an important solvent effect was noticed

Synthesis of novel pyrano[2,3-b]quinolines from simple acetanilides via intramolecular 1,3-dipolar cycloaddition

Some novel isoxazole and pyrazole fused pyrano[2,3-b]quinolines were synthesized from simple acetanilides via intramolecular 1,3-dipolar cycloaddition reactions involving nitrones, nitrile oxides and nitrile imines as 1,3-dipoles, in a regioselective manner

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A facile one pot synthesis of pyrazolo[3,4-D] pyrimidines

The reaction of 6-hydrazino uracils 1 with isocyanates 2 gave access to an efficient one-pot synthesis of pyrazolo[3,4- d]pyrimidines 3 in excellent yield