Child Internet Protection System

Nowadays internets is becoming an amazing resource and provide hours of fun for kids. Clearly there are many benefits that result from Internet usage, but there is a side to the internet that can be worrying for any parent. Internet is explored, in particular: child sexual exploitation; children\u27s exposure to sexually explicit or offensive material, so there is need of a system which prevents child abuse from internet. Currently many systems are developed to prevent Internetrelated child abuse. In this paper, we have developed a web page classification model, which will protect children from harmful and offensive material available on internet. Our approach uses entropy term weighting scheme, Principal Component Analysis for feature reduction and Back propagation neural network as classifier. Our experiment result shows that our approach performed well as comparison to other approaches

Analysis of Short Term and Long Term Dependence of Stream Flow Phenomenon in Seonath River Basin, Chhattisgarh

In this paper to investigate long rang phenomena ( Hurst effect) of river flows which characterizes hydrological time series is studied, especially in connection with various climate-related factors, is important to improve stochastic models for long-range phenomena and in order to understand the deterministic and stochastic variability in long-range dependence of stream flow. Long rang dependence represented by the Hurst coefficient H is estimated for 5 mean monthly discharge time series of Chhattisgarh state for a period of 32 years from 1980-2012.long memory analyzed for both monthly and seasonally stream flow time series of the Seonath River Basin at Chhattisgarh State by using Hurst exponent and testing specifically the null hypothesis of short-term memory in the monthly and seasonal time series by (Von Neumann ratio test, Kendall\u27s rank correlation test, Median crossing test, Run above and below the median for general randomness, Turning point test, Rank difference test)

CHEWING GUM: CONFECTIONARY TO A POPULAR TRANSBUCCAL DOSAGE FORM

Chewing gum is a highly convenient and controlled release transbuccal drug delivery system taken without water. It is gaining popularity as a selfadministrable carrier for the medication used for motion sickness, smoke cessation, hypertension, xerostomia, dental caries, pain, as nutritive and energy supplements. Functional chewing gum favors both local and systemic effects intended to be chewed about half an hour. It has emerged out with a fast onset of action either by direct absorption or swallowed with saliva into gastrointestinal tract.It has better bioavailability that lowers the doses and reduces the gastric side-effects. Gums adhere with ease and compliance of administration to children and dysphagia patients. Chewing gums are formulated using a water-insoluble gum base with water-soluble excipients with the active ingredient in the case of medicated gums. European Pharmacopeia standards used for release studies, there are no other particular official standards. It has attracted the researchers as successful potential drug delivery system in coming future. The present article reviews it as novel drug delivery system including its merits and limitations, material and methods of formulation and evaluation

Comparison of Contrast Enhanced Low-Dose Dobutamine Stress Echocardiography with 99mTc-Sestamibi Single-Photon Emission Computed Tomography in Assessment of Myocardial Viability

INTRODUCTION: Dobutamine stress echocardiography (DSE) and myocardial perfusion scan are the commonly used modalities to detect viable myocardium. DSE is comparatively cheaper and widely available but has a lower sensitivity. AIM: We aimed to compare contrast-enhanced low-dose dobutamine echocardiography (LDDE) and gated 99mTc-sestamibi myocardial perfusion scan (MPS) for the degree of agreement in the detection of myocardial viability. METHODS: We studied 850 left ventricular segments from 50 patients (42 men, mean age 55.5 years), with coronary artery disease and left ventricular systolic dysfunction (ejection fraction < 40%), using contrast-enhanced LDDE and 99mTc-Sestamibi gated SPECT. Segments were assessed for the presence of viability by both techniques and head to head comparisons were made. RESULTS: Adequate visualisation increased from 80% in unenhanced segments to 96% in contrast-enhanced segments. Of the total 850 segments studied, 290 segments (34.1%) had abnormal contraction (dysfunctional). Among these, 138 were hypokinetic (16.2% of total), 144 were severely hypokinetic or akinetic (16.9% of total), and 8 segments were dyskinetic or aneurismal (0.9% of total). Among 151 segments considered viable by technetium, 137 (90.7%) showed contractile improvement with dobutamine; in contrast, only 8 of the 139 segments (5.7%) considered nonviable by technetium had a positive dobutamine response. The per cent of agreement between technetium uptake and a positive response to dobutamine was 78.6% with kappa = 0.63, suggestive of a substantial degree of agreement between the two modalities. CONCLUSION: Use of contrast-enhanced LDDE significantly increased the adequate endocardial border visualisation. Furthermore, this study showed a strong degree of agreement between the modalities in the detection of viable segments. So, contrast-enhanced LDDE appears to be a safe and comparable alternative to MPS in myocardial viability assessment

Automatic Optical Imaging System for Mango Fruit using Hyperspectral Camera and Deep Learning Algorithm

This research paper explores focused on developing an automatic mango fruit quality detection system using a combination of artificial intelligence and the Internet of Things technologies. The system utilizes a hyperspectral camera to capture images of the mango fruit and image processing techniques to analyze the images. Deep learning algorithms are employed to classify the mango fruit based on quality parameters such as ripeness, size, and color. The proposed system aims to automate the mango fruit quality inspection process, improve the accuracy of quality assessment, and reduce human error. The results of this research could have applications in the food industry, specifically in the field of fruit quality inspection and sorting. Mango Fruit, Hyperspectral Camera, Image Processing, Deep Learning algorithms, Quality Recognition

Minor spliceosome and disease

tThe U12-dependent (minor) spliceosome excises a rare group of introns that are characterized by ahighly conserved 5splice site and branch point sequence. Several new congenital or somatic diseaseshave recently been associated with mutations in components of the minor spliceosome. A commontheme in these diseases is the detection of elevated levels of transcripts containing U12-type introns,of which a subset is associated with other splicing defects. Here we review the present understandingof minor spliceosome diseases, particularly those associated with the specific components of the minorspliceosome. We also present a model for interpreting the molecular-level consequences of the differentdiseases.Peer reviewe

Wind Energy Conversion System With Permanent Magnetic Synchronous Generator

This paper presents a study on grid-connected WECS with PMSG. The application of non-conventional energy resources develops much rapidly to improve low carbon energy resources in India. Nowadays, we are going to depend on solar, wind for the fulfillment of energy demand. Wind energy applications develop much more rapidly than other renewable resources such as solar, geothermal, and so on in the 21st century. It becomes the third core energy resource following non-conventional fuels as oil and chemical. The electrical energy generated by wind power plants is the best developing and most promising renewable energy source. The wind is a clean, free, and limitless energy source. Wind Energy Generation Systems (WECS) are confronted with increasing demands for power quality and harmonic distortion control. With the advance in power electronics technology, the fast growth of variable speed WECS is now witnessed

Alternative exon definition events control the choice between nuclear retention and cytoplasmic export of U11/U12-65K mRNA

Cellular homeostasis of the minor spliceosome is regulated by a negative feed-back loop that targets U11-48K and U11/U12-65K mRNAs encoding essential components of the U12-type intron-specific U11/U12 di-snRNP. This involves interaction of the U11 snRNP with an evolutionarily conserved splicing enhancer giving rise to unproductive mRNA isoforms. In the case of U11/U12-65K, this mechanism controls the length of the 3' untranslated region (3'UTR). We show that this process is dynamically regulated in developing neurons and some other cell types, and involves a binary switch between translation-competent mRNAs with a short 3'UTR to non-productive isoforms with a long 3'UTR that are retained in the nucleus or/and spliced to the downstream amylase locus. Importantly, the choice between these alternatives is determined by alternative terminal exon definition events regulated by conserved U12-and U2-type 50 splice sites as well as sequence signals used for pre-mRNA cleavage and polyadenylation. We additionally show that U11 snRNP binding to the U11/U12-65K mRNA species with a long 3'UTR is required for their nuclear retention. Together, our studies uncover an intricate molecular circuitry regulating the abundance of a key spliceosomal protein and shed new light on the mechanisms limiting the export of non-productively spliced mRNAs from the nucleus to the cytoplasm.Peer reviewe

IMPORTANCE OF NANOCARRIERS AND PROBIOTICS IN THE TREATMENT OF ULCERATIVE COLITIS

Ulcerative colitis (UC) is an inflammatory chronic disease primarily affecting the colonic mucosa; the extent and severity of colon involvement are variable. Ulcerative colitis is identified by mucus diarrhea, tenesmus, bowel distension, and anemia. 5-aminosalicylic acid drugs, steroids, and immune suppressants are used for the therapy of ulcerative colitis. The mainchallenges in the management of thediseaseare drug-related side-effects and local targeting. To overcome these challengesprobiotics and micro and Nanoparticulate systemauspiciousapproaches to overcome drug-related adverse side effects and local targeting.Upon ingestion, the probiotics can result in beneficial health effects. Probiotics and micro and nanoparticulate approaches for suitable targeting and overcome the drug-associated side effect. Probiotics are mainly used as gut modulators but are also nowadays explored for their use in ulcerative colitis.The current therapeutic goals are to achieve clinical remission along with mucosal healing, avoidance of complications such as side effects of the drug and to improve the quality of life. The use of probiotics to increase the health of the intestine and used to block or manage intestinal disorders. They may prevent the induction of inflammatory reactions. Probiotics must be inspected for efficacy in the prevention and management of a wide spectrum of gastrointestinal diseases, like antibiotic-associated diarrhea.Micro and Nanoparticulate drug delivery system has been achieving huge importance for targeting of the drug to colon locally at a controlled and sustained rate