ESTIMATION OF THE DRUG-DRUG AND DRUG-POLYMER OPHTHALMIC COMPLEX AT STOICHIOMETRY BY TERNARY PHASE BEHAVIOUR

Objective: The study focus on the drug-drug and drug-polymer interaction and their estimation at stoichiometry when such systems were formed. In this discovery we tried to make use of the latest research and novel concepts to explore the drug-polymer-polymer Ionic ternary InteractionMethods: Partial ternary phase diagrams were constructed and the stoichiometry of the ciprofloxacin/anionic polymer interaction was assessed in distilled water by means of dialysis equilibrium. The polymers were completely hydrated in distilled water by gentle stirring at room temperature and studied for viscosity and turbidimetric measurements.Results: Comparing the partial ternary phase diagrams of the different anionic to each other. PAA exhibited the largest gel area even with low polymer content. The anionic polymers HA and PAA showed good capability to interact with the drug giving soluble drug/polymer complexes; moreover they were able to form polymer/polymer complexes with Poloxamer and HCS, with a stoichiometry depending on the polymers involved.Conclusion: From the results of the present study, it can be concluded that formulations were made isotonic and favours corneal permeation of both the drug. Ocular Irritancy denotes formulations were quite stable & useful in novel format of sol-gel transformations.Â

FORMULATION AND EVALUATION OF OPHTHALMIC GEL BASED ON DRUG-POLYMER-POLYMER TERNARY INTERACTION

 Objective: The objective was to enhance the amount of active substance reaching the target tissue or exerting a local effect in the cul-de-sac, theapproach we use is the application of in-situ gelling systems or phase transition systems, which are instilled in a liquid form and shift to a gel or solidphase in the cul-de-sac. The present study will focus on the development of formulation of ophthalmic gels. The polymer physicochemical propertieswere studied for the improvement in gel characteristics.Methods: The formulations were varied by the amount of the anionic and cationic polymer concentration. The 10 and 20-fold excess anionic polymerwere used. The 10 and 20-fold excess anionic polymer were used. Further cationic polymers were utilized to see any ternary interaction betweendrug and polymers.Results: From the present study it could be shown that most of the formulations were isotropic and could be clearly separated from the anisotropicones which were situated at the cationic side of the phase diagram only as well as at 10% polyvinyl alcohol. Furthermore, excess 20HA, 10PAA, and20PAA as well as HCS (HCS/20PAA) contributes to improve drug release control.Conclusion: The above formulation of were found to be quite stable and useful in the novel format of sol-gel transformations. Further, the physicalcharacteristics gels show better tolerability with anionic and cationic polymer.Keywords: Cationic, Anionic, Poloxamer, Sol-gel