MR Brain Image Classification: A Comparative Study on Machine Learning Methods

The brain tissue classification from magnetic resonance images provides valuable insight in neurological research study. A significant number of computational methods have been developed for pixel classification of magnetic resonance brain images. Here, we have shown a comparative study of various machine learning methods for this. The results of the classifiers are evaluated through prediction error analysis and several other performance measures. It is noticed from the results that the Support Vector Machine outperformed other classifiers. The superiority of the results is also established through statistical tests called Friedman test

Application of RotaSVM for HLA class II Protein-Peptide Interaction Prediction

In this article, the recently developed RotaSVM is used for accurate prediction of binding peptides to Human Leukocyte Antigens class II (HLA class II) proteins. The HLA II - peptide complexes are generated in the antigen presenting cells (APC) and transported to the cell membrane to elicit an immune response via T-cell activation. The understanding of HLA class II protein-peptide binding interaction facilitates the design of peptide-based vaccine, where the high rate of polymorphisms in HLA class II molecules poses a big challenge. To determine the binding activity of 636 non-redundant peptides, a set of 27 HLA class II proteins are considered in the present study. The prediction of HLA class II - peptide binding is carried out by an ensemble classifier called RotaSVM. In RotaSVM, the feature selection scheme generates bootstrap samples that are further used to create a diverse set of features using Principal Component Analysis. Thereafter, Support Vector Machines are trained with th ese bootstrap samples with the integration of their original feature values. The effectiveness of the RotaSVM for HLA class II protein-peptide binding prediction is demonstrated in comparison with other traditional classifiers by evaluating several validity measures with the visual plot of ROC curves. Finally, Friedman test is conducted to judge the statistical significance of RotaSVM in prediction of peptides binding to HLA class II proteins