Design and Development of Domestic Solar Dryer with Comparative Analysis of Nutritional Aspect of Dried Raisins

Solar dryer technology is simple and can be implemented by households and small communities due to its simplicity. The suitable design of the absorber/collector is very vital for any solar drying system as the collector efficiency plays a key role in determining the overall system drying efficiency. To study the practical applicability of a developed solar dryer, grapes were dried in the drying chamber of a designed and developed solar dryer and for comparison, in open sunlight. Faster drying was noted for the grapes dried in the unit. The study on nutritional aspects indicated that solar drying process retained the major nutritional components like total sugars, total proteins and total lipids in raisins. The comparison between the solar dried raisins and open sun dried ones showed a higher ash content of 2.71% with solar dried ones and 1.95% in case of open sun dried raisins. The quantity of MUFA content was also affected by the varying drying practices implemented with 10.95% and 7.12% MUFA in solar dried and open sun dried raisins respectively. The drying technique also affects the bacterial load on raisins as observed in our current study with negligible bacterial growth on on solar dried raisins compared to open dried ones

An impact of gap acceptance on road safety: A critical systematic review

An uncontrolled intersection is a critical area for crashes that depends on macroscopic traffic parameters. While the intersection is the potential of the center of crashes due to inappropriate decision of driver. Therefore, the study focuses on the effect of the gap acceptance parameter for the safety of drivers at an uncontrolled intersection. To examine, a systematic review of the literature is implemented to understand the different parameters, their impact, and models developed by the researchers. Additionally, it is demonstrated that the crashes are highly affected by the gap acceptance and the different models are formed to estimate the critical gap for different road sections under homogeneous and heterogeneous traffic conditions. However, it is not possible to definitively conclude the best model to evaluate the gap acceptance factor but can be preferred to reduce the severity of crashes. Nonetheless, most studies remain inconclusive, there is an emerging trend in the literature suggesting the increase of the crash risk at an uncontrolled intersection. Lastly, it is most important to mention the model suitability based on empirical studies commenced under the strong limitations. Consequently, there is a need for research in this area to correlate the gap acceptance with road safety to reduce the severity of accidents to improve the existing transportation system

Hypoxia-inducing cryogels uncover key cancer-immune cell interactions in an oxygen-deficient tumor microenvironment

Hypoxia is a major factor shaping the immune landscape, and several cancer models have been developed to emulate hypoxic tumors. However, to date, they still have several limitations, such as the lack of reproducibility, inadequate biophysical cues, limited immune cell infiltration, and poor oxygen (O2) control, leading to non-pathophysiological tumor responses. Therefore, it is essential to develop better cancer models that mimic key features of the tumor extracellular matrix and recreate tumor-associated hypoxia while allowing cell infiltration and cancer-immune cell interactions. Herein, hypoxia-inducing cryogels (HICs) have been engineered using hyaluronic acid (HA) to fabricate three-dimensional microtissues and model a hypoxic tumor microenvironment. Specifically, tumor cell-laden HICs have been designed to deplete O2 locally and induce long-standing hypoxia. HICs promoted changes in hypoxia-responsive gene expression and phenotype, a metabolic adaptation to anaerobic glycolysis, and chemotherapy resistance. Additionally, HIC-supported tumor models induced dendritic cell (DC) inhibition, revealing a phenotypic change in the plasmacytoid DC (pDC) subset and an impaired conventional DC (cDC) response in hypoxia. Lastly, our HIC-based melanoma model induced CD8+ T cell inhibition, a condition associated with the downregulation of pro-inflammatory cytokine secretion, increased expression of immunomodulatory factors, and decreased degranulation and cytotoxic capacity of T cells. Overall, these data suggest that HICs can be used as a tool to model solid-like tumor microenvironments and has great potential to deepen our understanding of cancer-immune cell relationship in low O2 conditions and may pave the way for developing more effective therapies