Community views on ‘Can perinatal services safely identify Aboriginal and Torres Strait Islander parents experiencing complex trauma?’

Family and extended kinship systems which nurture healthy, happy children are central to Aboriginal and Torres Strait Islander cultures. Since colonisation, Aboriginal and Torres Strait Islander communities have been impacted by intergenerational cycles of trauma, stemming from colonial violence, genocidal policies and discrimination, including the forced removal of children from their families. Becoming a parent offers a unique life-course opportunity for trauma recovery and preventing intergenerational trauma. However, identifying or ‘recognising’ complex trauma carries significant risk of harm for Aboriginal and Torres Strait Islander parents due to reactive prenatal child protection involvement potentially compounding experiences of trauma, and limited benefits due to lack of culturally appropriate support. The Aboriginal-led participatory Healing the Past by Nurturing the Future project aims to co-design safe, accessible and feasible perinatal awareness, recognition, assessment and support strategies for Aboriginal and Torres Strait Islander parents experiencing complex trauma. This paper presents views of 38 workshop participants to determine prerequisites for ensuring benefits outweigh risks of assessment to safely recognise parents experiencing complex trauma, consistent with screening criteria. Six essential elements were identified from thematic analysis: high-quality holistic care; cultural, social and emotional safety; empowerment, choice and control; flexible person-centred approaches; trusting relationships; and sensitive, skilled communication

HIPASS High-Velocity Clouds: Properties of the Compact and Extended Populations

A catalog of Southern anomalous-velocity HI clouds at Decl. < +2 deg is presented, based on data from the HI Parkes All-Sky Survey (HIPASS). The improved sensitivity (5sigma: T_B = 0.04 K) and resolution (15.5') of the HIPASS data results in a substantial increase in the number of individual clouds (1956, as well as 41 galaxies) compared to previous surveys. Most high-velocity emission features, HVCs, have a filamentary morphology and are loosely organized into large complexes extending over tens of degrees. In addition, 179 compact and isolated anomalous-velocity objects, CHVCs, are identified based on their size and degree of isolation. 25% of the CHVCs originally classified by Braun & Burton (1999) are reclassified. Both the entire population of high-velocity emission features and the CHVCs alone have typical HI masses of ~ 4.5 D(kpc)^2 solar masses and have similar slopes for their column density and flux distributions. On the other hand, the CHVCs appear to be clustered and the population can be broken up into three spatially distinct groups, while the entire population of clouds is more uniformly distributed with a significant percentage aligned with the Magellanic Stream. The median velocities are V_GSR = -38 km/s for the CHVCs and -30 km/s for all of the anomalous-velocity clouds. Based on the catalog sizes, high-velocity features cover 19% of the southern sky and CHVCs cover 1%. (abridged)Comment: 32 pages, 26 figures in gif format, 2 ascii tables, to appear in the Jan 2002 issue of The Astronomical Journal, high resolution version available at http://origins.Colorado.EDU/~mputman/pubs.htm

The Large Scale Distribution of Neutral Hydrogen in the Fornax Region

Using HIPASS data, we have searched for HI in a ~25x25 sq.deg. region centred on the Fornax cluster. Within a velocity search range of 300 - 3700 km/s and a lower flux limit of ~40 mJy, 110 galaxies with HI emission were detected, one of which is previously uncatalogued. None of the detections has early-type morphology. Previously unknown velocities for 14 galaxies have been determined, with a further 4 velocity measurements being significantly dissimilar to published values. Identification of an optical counterpart is relatively unambiguous for more than ~90% of our HI galaxies. The galaxies appear to be embedded in a sheet at the cluster velocity which extends for more than 30 deg across the search area. At the nominal cluster distance of ~20 Mpc, this corresponds to an elongated structure more than 10 Mpc in extent. A velocity gradient across the structure is detected, with radial velocities increasing by \~500 km/s from SE to NW. The clustering of galaxies evident in optical surveys is only weakly suggested in the spatial distribution of our HI detections. Our results suggest a considerable deficit of HI-rich galaxies in the centre of the cluster. However, relative to the field, there is a 3(+/-1)-fold excess of HI-rich galaxies in the outer parts of the cluster where galaxies may be infalling towards the cluster for the first time.Comment: 16 pages, 14 figures, 110 HI spectra. To be published in MNRA

Observations of red-giant variable stars by Aboriginal Australians

Aboriginal Australians carefully observe the properties and positions of stars, including both overt and subtle changes in their brightness, for subsistence and social application. These observations are encoded in oral tradition. I examine two Aboriginal oral traditions from South Australia that describe the periodic changing brightness in three pulsating, red-giant variable stars: Betelgeuse (Alpha Orionis), Aldebaran (Alpha Tauri), and Antares (Alpha Scorpii). The Australian Aboriginal accounts stand as the only known descriptions of pulsating variable stars in any Indigenous oral tradition in the world. Researchers examining these oral traditions over the last century, including anthropologists and astronomers, missed the description of these stars as being variable in nature as the ethnographic record contained several misidentifications of stars and celestial objects. Arguably, ethnographers working on Indigenous Knowledge Systems should have academic training in both the natural and social sciences.Comment: The Australian Journal of Anthropology (2018

An Extragalactic HI Cloud with No Optical Counterpart?

We report the discovery, from the HI Parkes All-Sky Survey (HIPASS), of an isolated cloud of neutral hydrogen which we believe to be extragalactic. The HI mass of the cloud (HIPASS J1712-64) is very low, 1.7 x 10^7 Msun, using an estimated distance of ~3.2 Mpc. Most significantly, we have found no optical companion to this object to very faint limits (mu(B)~ 27 mag arcsec^-2). HIPASS J1712-64 appears to be a binary system similar to, but much less massive than, HI 1225+01 (the Virgo HI Cloud) and has a size of at least 15 kpc. The mean velocity dispersion, measured with the Australia Telescope Compact Array (ATCA), is only 4 km/s for the main component and because of the weak or non-existent star-formation, possibly reflects the thermal linewidth (T<2000 K) rather than bulk motion or turbulence. The peak column density for HIPASS J1712-64, from the combined Parkes and ATCA data, is only 3.5 x 10^19 cm^-2, which is estimated to be a factor of two below the critical threshold for star formation. Apart from its significantly higher velocity, the properties of HIPASS J1712-64 are similar to the recently recognised class of Compact High Velocity Clouds. We therefore consider the evidence for a Local Group or Galactic origin, although a more plausible alternative is that HIPASS J1712-64 was ejected from the interacting Magellanic Cloud/Galaxy system at perigalacticon ~ 2 x 10^8 yr ago.Comment: 23 pages, 7 figures, AJ accepte

The 1000 Brightest HIPASS Galaxies: HI Mass Function and Omega_HI

We present a new accurate measurement of the HI mass function of galaxies from the HIPASS Bright Galaxy Catalog, a sample of 1000 galaxies with the highest HI peak flux densities in the southern hemisphere (Koribalski et al. 2003). This sample spans nearly four orders of magnitude in HI mass (from log M_HI/M_sun=6.8 to 10.6, H0=75) and is the largest sample of HI selected galaxies to date. We develop a bivariate maximum likelihood technique to measure the space density of galaxies, and show that this is a robust method, insensitive to the effects of large scale structure. The resulting HI mass function can be fitted satisfactorily with a Schechter function with faint-end slope alpha=-1.30. This slope is found to be dependent on morphological type, with later type galaxies giving steeper slopes. We extensively test various effects that potentially bias the determination of the HI mass function, including peculiar motions of galaxies, large scale structure, selection bias, and inclination effects, and quantify these biases. The large sample of galaxies enables an accurate measurement of the cosmological mass density of neutral gas: Omega_HI=(3.8 +/- 0.6) x 10^{-4}. Low surface brightness galaxies contribute only 15% to this value, consistent with previous findings.Comment: accepted for publication in Astronomical Journal, 16 pages, including 17 figures. Corrected typos and reference

Innate Immune Molecule NLRC5 Protects Mice From Helicobacter-induced Formation of Gastric Lymphoid Tissue

BACKGROUND &amp; AIMS: Helicobacter pylori induces strong inflammatory responses that are directed at clearing the infection, but if not controlled, these responses can be harmful to the host. We investigated the immune-regulatory effects of the innate immune molecule, nucleotide-binding oligomerization domain-like receptors (NLR) family CARD domaincontaining 5 (NLRC5), in patients and mice with Helicobacter infection. METHODS: We obtained gastric biopsies from 30 patients in Australia. We performed studies with mice that lack NLRC5 in the myeloid linage (Nlrc5(memptysetKO)) and mice without Nlrc5 gene disruption (controls). Some mice were gavaged with H pylori SS1 or Helicobacter felis; 3 months later, stomachs, spleens, and sera were collected, along with macrophages derived from bone marrow. Human and mouse gastric tissues and mouse macrophages were analyzed by histology, immunohistochemistry, immunoblots, and quantitative polymerase chain reaction. THP-1 cells (human macrophages, controls) and NLRC5(-/-) THP-1 cells (generated by CRISPR-Cas9 gene editing) were incubated with Helicobacter and gene expression and production of cytokines were analyzed. RESULTS: Levels of NLRC5 messenger RNA were significantly increased in gastric tissues from patients with H pylori infection, compared with patients without infection ( P &lt;.01), and correlated with gastritis severity (P&lt;.05). H pylori bacteria induced significantly higher levels of chemokine and cytokine production by NLRC5(-/-) THP-1 macrophages than by control THP- 1 cells (P&lt;.05). After 3 months of infection with H felis, Nlrc5(memptyset-KO) mice developed gastric hyperplasia (P&lt;.0001), splenomegaly (P &lt;.0001), and increased serum antibody titers (P&lt;.01), whereas control mice did not. Nlrc5(memptyset-KO) mice with chronic H felis infection had increased numbers of gastric B-cell follicles expressing CD19 (P&lt;.0001); these follicles had features of mucosa-associated lymphoid tissue lymphoma. We identified B-cell-activating factor as a protein that promoted B-cell hyperproliferation in Nlrc5(memptyset-KO) mice. CONCLUSIONS: NLRC5 is a negative regulator of gastric inflammation and mucosal lymphoid formation in response to Helicobacter infection. Aberrant NLRC5 signaling in macrophages can promote B-cell lymphomagenesis during chronic Helicobacter infection

Role of aetiology in the progression, regression, and parenchymal remodelling of liver disease: implications for liver biopsy interpretation

Clinicopathological concepts on acute and chronic liver disease have evolved rapidly during the last few years, with advances in general and specific treatment options and improved patient outcomes. The old paradigm of ‘irreversibility’ of cirrhosis had been challenged in major ways, and the validity of the usage of the term ‘cirrhosis’ has come into question. This paper addresses aetiology-based clinicopathological concepts and features that may deserve attention because they may determine disease outcome and, specifically, patterns of regression and remodelling. A variety of therapeutic interventions may influence remaining disease features after elimination of damaging agents (virus, alcohol, etc.), and determine the final clinical outcome including the risk of hepatocellular carcinoma (HCC). New concepts create new responsibilities and opportunities for the pathologist to contribute to the understanding of liver pathology and communicate this with clinical colleagues and researchers

A catalog of HI-selected galaxies from the south celestial cap region of sky

The first deep catalog of the H I Parkes All Sky Survey (HIPASS) is presented, covering the south celestial cap (SCC) region. The SCC area is similar to2400 deg(2) and covers delta < -62&DEG;. The average rms noise for the survey is 13 mJy beam(-1). Five hundred thirty-six galaxies have been cataloged according to their neutral hydrogen content, including 114 galaxies that have no previous cataloged optical counterpart. This is the largest sample of galaxies from a blind H I survey to date. Most galaxies in optically unobscured regions of sky have a visible optical counterpart; however, there is a small population of low-velocity H I clouds without visible optical counterparts whose origins and significance are unclear. The rms accuracy of the HIPASS positions is found to be 1.'9. The H I mass range of galaxies detected is from &SIM;10(6) to &SIM;10(11) M-.. There are a large number of late-type spiral galaxies in the SCC sample (66%), compared with 30% for optically selected galaxies from the same region in the NASA Extragalactic Database. The average ratio of H I mass to B luminosity of the sample increases according to optical type, from 1.8 M-./L-. for early types to 3.2 M-./L-. for late-type galaxies. The H I-detected galaxies tend to follow the large-scale structure traced by galaxies found in optical surveys. From the number of galaxies detected in this region of sky, we predict the full HIPASS catalog will contain &SIM;5000 galaxies, to a peak flux density limit of &SIM;39 mJy (3 σ), although this may be a conservative estimate as two large voids are present in the region. The H I mass function for this catalog is presented in a subsequent paper