3 Dimensional Virtual Modelling of Human Femur Bone with Prosthetic Plate and Screws

Femur bone is the longest and stronger bone in the human body. This bone is contained a linear-elastic, isotropic and homogeneous material of calcium phosphate. It needs to support maximum weight of the body in between hip joint and knee joint during different mode of body posture. Firstly 3 dimension geometric model of femur bone, prosthetic plate and screw is generated in Solid works CAD software which seems to define high mode of difficulty for generating the bone model. The objective of femur bone CAD model is identified the maximum stresses and deformation zone by applying the static load into the finite element ANSYS software. Further femur bone is provided a single crack at maximum stressed zone implanted with prosthetic bone plate and screws

APPLICATIONS ON TOP OF DNA CENTER: AUTOMATIC CONFIGURATION VALIDATION BASED ON TOPOLOGY FOR BASIC INTEROPERATION

A rule based service is provided for Configuration Simulation and Validation (CSV) for the devices managed on given network. With an understanding of the architecture of a network, the service can be employed to determine which devices need to be in the same Internet Protocol (IP) subnet. The service can be employed to suggest one or more configuration changes to the administrator such as, changes to address as a potential misconfiguration, improve operation, etc

APPLICATIONS ON TOP OF DNA CENTER: TOPOLOGY EVOLUTION BASED ON CUSTOMER NETWORK DYNAMICS

Techniques are provided for detecting and managing dynamically changing loads in a network, for example, during large scale events that may cause a bottleneck such as a stadium game event or a musical concert. These techniques allow network administrators to improve network efficiency by monitoring and tweaking the network capabilities in order to handle network load during periods of high demand without a detailed background knowledge of the network

The Chronicle of French Revolution in Alejo Carpentier’s Explosion in a Cathedral

Alejo Carpentier was a well-known author of Latin American Literature of twentieth century. Explosion in a Cathedral, (El siglo de las luces, 1962) has disclosed the author’s approach, who knew how to take advantages of the chance. This is considered Carpentier’s most effective historical achievement that revealed his destiny accidently. The novel is based on chronicle of French revolution in different circumstances and revealed the French history with winning destiny. It portrays the revolutionary hurdles, which were adopted from the other historians, who wrote about revolutions. Ultimately, Carpentier became successful to assemble immense information, dates and several documents; which were required to write the history of French revolution. The novel presents rare figures as characters without giving more importance to them. Some critics argued that it is characters who are more influenced with European modernity less than Latin America. The novel is about French revolution that is depicted through the character Victor Huggies and Esteban. The French revolution was fought twice as land and water with great efforts. The novel leaves it’s most noteworthy mark in the field of history

ASSESSMENT OF MAGNESIUM (MG) AND ZINC (ZN) IN CARCINOMA BREAST PATIENTS

Objectives: The objectives of the study were to determine and compare serum magnesium (Mg) and zinc (Zn) concentrations between breast carcinoma patients and healthy controls. Methods: Determination and comparison of serum Mg and Zn was done between 50 breast carcinoma patients and 50 healthy controls. Determination and comparison of LFT in between 50 breast cancer patient during different course of chemotherapy. Trace element analysis was done using atomic absorption spectrophotometry. Statistical comparison was done, results were expressed as Mean±SD, p<0.05 was considered to be statistically significant. Results: All groups were statistically matched in age, sex, and p>0.05. Serum Mg concentrations in cases and controls (0.9920±0.38 mg/dL) and (1.49±0.58 mg/dL) respectively, p≤0.0001* serum Zn concentrations in cases and controls were (66.74±12.58 μg/dL) and (90.88±14.51 μg/dL), respectively, p≤0.0001*. Conclusion: Both serum (Zn) and (Mg) showed significant decreases in breast carcinoma patients as compare to healthy controls

Expression of Human Globin Genes in Transgenic Mice Carrying the Β-Globin Gene Cluster with a Mutation Causing G ΓΒ + Hereditary Persistence of Fetal Hemoglobin a

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73405/1/j.1749-6632.1990.tb24303.x.pd

Japanese Encephalitis Outbreak, India, 2005

An outbreak of viral encephalitis occurred in Gorakhpur, India, from July through November 2005. The etiologic agent was confirmed to be Japanese encephalitis virus by analyzing 326 acute-phase clinical specimens for virus-specific antibodies and viral RNA and by virus isolation. Phylogenetic analysis showed that these isolates belonged to genogroup 3

Acetone detection using thin tungsten oxide (WO3) film based gas sensor

Acetone being a volatile organic compound is found in human breath. Non-invasive breath analysis for detection of diabetes has gained remarkable attention for the past few years. Human breath has ample of volatile organic compounds pertaining to numerous diseases in the body. Acetone in breath has been proven to be an important biomarker for diagnosis of diabetes through breath. Here, tungsten oxide (WO3) thin films of nanometer thickness have been used for this purpose. The detector films are sputtered over silicon dioxide layer and corresponding connections are made over the film to measure the resistance change. Acetone, being a reducing gas, reduces the resistance of the film as it comes in contact. Different concentrations in parts per million (ppm) have been tested on these nanometer films having thickness of 100 nm over a chip size of 5 mm x 5 mm, as low as 1.2 ppm. Optimum temperature has also been computed to be 300 oC. The topography of film has been characterized by atomic force microscopy (AFM) and a mean grain size of 24.1 nanometers has been observed

Durand et al 2012 Supplemental figures

Objective. Our objective was to compare the osteoclastogenic capacity of peripheral blood mononuclear cells (PBMCs) from patients with osteoarthritis (OA) to that of PBMCs from self-reported normal individuals. Methods. PBMCs from 140 patients with OA and 45 healthy donors were assayed for CD14+ expression and induced to differentiate into osteoclasts (OCs) over 3 weeks in vitro. We assessed the number of the OCs, their resorptive activity, OC apoptosis, and expression of the following cytokine receptors: receptor activator of nuclear factor κB (RANK), interleukin-1 receptor type I (IL-1R1) and IL-1R2. A ridge logistic regression classifier was developed to discriminate OA patients from controls. Results. PBMCs from OA patients gave rise to more OCs that resorbed more bone surface than did PBMCs from controls. The number of CD14+ precursors was comparable in both groups, but there was less apoptosis in OCs obtained from OA patients. Although no correlation was found between osteoclastogenic capacity and clinical or radiologic scores, levels of IL-1R1 were significantly lower in cultures from patients with OA compared to controls. OC apoptosis and expression levels of IL-1R1 and IL-1R2 were used to build a multivariate predictive model for OA. Conclusion. During 3 weeks of culture under identical conditions, monocytes from patients with OA display enhanced capacity to generate OCs compared to cells from controls. Enhanced osteoclastogenesis is accompanied by increased resorptive activity, reduced OC apoptosis and diminished IL-1R1 expression. These findings support the possibility that generalized changes in bone metabolism affecting OCs participate in the pathophysiology of OA

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy