Measuring Social Influence in Online Social Networks - Focus on Human Behavior Analytics

With the advent of online social networks (OSN) and their ever-expanding reach, researchers seek to determine a social media user’s social influence (SI) proficiency. Despite its exploding application across multiple domains, the research confronts unprecedented practical challenges due to a lack of systematic examination of human behavior characteristics that impart social influence. This work aims to give a methodical overview by conducting a targeted literature analysis to appraise the accuracy and usefulness of past publications. The finding suggests that first, it is necessary to incorporate behavior analytics into statistical measurement models. Second, there is a severe imbalance between the abundance of theoretical research and the scarcity of empirical work to underpin the collective psychological theories to macro-level predictions. Thirdly, it is crucial to incorporate human sentiments and emotions into any measure of SI, particularly as OSN has endowed everyone with the intrinsic ability to influence others. The paper also suggests the merits of three primary research horizons for future considerations

A review on motivational nudges for enhancing building energy conservation behavior

This paper explores energy use interventions and their influence on human behavior in commercial and institutional buildings. The main objectives of this paper are to identify the importance of nudges in reducing building energy usage and the implementation methods that can influence users to conserve energy in buildings through context specific interventions. A qualitative research method is used to elicit existing energy saving techniques, and a rigorous literature review is conducted to demonstrate the effectiveness of nudges. The investigation shows that combining multiple influencing options and interactive technological interventions can result in an effective nudging mechanism at a larger scale. Widely adopted technological tools identified in energy conservation in buildings included eco-feedback systems, IoT engagement systems, and recommendation systems that shared clear information to enable users to change their behavior. Besides, non-technological tools, such as posters and moral appeal by word of mouth, are highlighted as influencing user behavior to conserve energy in buildings. The use of nudges in commercial and institutional buildings has been studied in this review, and it has been demonstrated that the combination of influencing techniques is more effective than deploying a particular technique. It is concluded that energy conservation can be predicated in agent-based environments by modeling integrated nudges in future work

Investigating the impact of actual and modeled occupant behavior information input to building performance simulation

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. Occupant behaviors are one of the most dominant factors that influence building energy use. Understanding the influences from building occupants can promote the development of energy- efficient buildings. This paper quantifies the impact of different occupant behavior information on building energy model (BEM) from multiple perspectives. For this purpose, an occupant behavior model that uses agent-based modeling (ABM) approach is implemented via co-simulation with a BEM of an existing commercial building. Then, actual occupant behavior data in correspondence to ABM output, including operations on window, door, and blinds in selected thermal zones of the building are recorded using survey logs. A simulation experiment is conducted by creating three BEMs with constant, actual, and modeled occupant behavioral inputs. The analysis of the simulation results among these scenarios helps us gain an in-depth understanding of how occupant behaviors influence building performance. This study aims to facilitate robust building design and operation with human-in-the-loop system optimization

Magnetoelectric ordering of BiFeO3 from the perspective of crystal chemistry

In this paper we examine the role of crystal chemistry factors in creating conditions for formation of magnetoelectric ordering in BiFeO3. It is generally accepted that the main reason of the ferroelectric distortion in BiFeO3 is concerned with a stereochemical activity of the Bi lone pair. However, the lone pair is stereochemically active in the paraelectric orthorhombic beta-phase as well. We demonstrate that a crucial role in emerging of phase transitions of the metal-insulator, paraelectric-ferroelectric and magnetic disorder-order types belongs to the change of the degree of the lone pair stereochemical activity - its consecutive increase with the temperature decrease. Using the structural data, we calculated the sign and strength of magnetic couplings in BiFeO3 in the range from 945 C down to 25 C and found the couplings, which undergo the antiferromagnetic-ferromagnetic transition with the temperature decrease and give rise to the antiferromagnetic ordering and its delay in regard to temperature, as compared to the ferroelectric ordering. We discuss the reasons of emerging of the spatially modulated spin structure and its suppression by doping with La3+.Comment: 18 pages, 5 figures, 3 table

Preclinical testing of the glycogen synthase kinase-3β inhibitor tideglusib for rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is the most common childhood soft tissue sarcoma. RMS often arise from myogenic precursors and displays a poorly differentiated skeletal muscle phenotype most closely resembling regenerating muscle. GSK3β is a ubiquitously expressed serine-threonine kinase capable of repressing the terminal myogenic differentiation program in cardiac and skeletal muscle. Recent unbiased chemical screening efforts have prioritized GSK3β inhibitors as inducers of myodifferentiation in RMS, suggesting efficacy as single agents in suppressing growth and promoting self-renewal in zebrafish transgenic embryonal RMS (eRMS) models in vivo. In this study, we tested the irreversible GSK3β-inhibitor, tideglusib for in vivo efficacy in patient-derived xenograft models of both alveolar rhabdomyosarcoma (aRMS) and eRMS. Tideglusib had effective on-target pharmacodynamic efficacy, but as a single agent had no effect on tumor progression or myodifferentiation. These results suggest that as monotherapy, GSK3β inhibitors may not be a viable treatment for aRMS or eRMS

Preclinical rationale for entinostat in embryonal rhabdomyosarcoma

BACKGROUND: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in the pediatric cancer population. Survival among metastatic RMS patients has remained dismal yet unimproved for years. We previously identified the class I-specific histone deacetylase inhibitor, entinostat (ENT), as a pharmacological agent that transcriptionally suppresses the PAX3:FOXO1 tumor-initiating fusion gene found in alveolar rhabdomyosarcoma (aRMS), and we further investigated the mechanism by which ENT suppresses PAX3:FOXO1 oncogene and demonstrated the preclinical efficacy of ENT in RMS orthotopic allograft and patient-derived xenograft (PDX) models. In this study, we investigated whether ENT also has antitumor activity in fusion-negative eRMS orthotopic allografts and PDX models either as a single agent or in combination with vincristine (VCR). METHODS: We tested the efficacy of ENT and VCR as single agents and in combination in orthotopic allograft and PDX mouse models of eRMS. We then performed CRISPR screening to identify which HDAC among the class I HDACs is responsible for tumor growth inhibition in eRMS. To analyze whether ENT treatment as a single agent or in combination with VCR induces myogenic differentiation, we performed hematoxylin and eosin (H&E) staining in tumors. RESULTS: ENT in combination with the chemotherapy VCR has synergistic antitumor activity in a subset of fusion-negative eRMS in orthotopic "allografts," although PDX mouse models were too hypersensitive to the VCR dose used to detect synergy. Mechanistic studies involving CRISPR suggest that HDAC3 inhibition is the primary mechanism of cell-autonomous cytoreduction in eRMS. Following cytoreduction in vivo, residual tumor cells in the allograft models treated with chemotherapy undergo a dramatic, entinostat-induced (70-100%) conversion to non-proliferative rhabdomyoblasts. CONCLUSION: Our results suggest that the targeting class I HDACs may provide a therapeutic benefit for selected patients with eRMS. ENT's preclinical in vivo efficacy makes ENT a rational drug candidate in a phase II clinical trial for eRMS

Global overview of the management of acute cholecystitis during the COVID-19 pandemic (CHOLECOVID study)

Background: This study provides a global overview of the management of patients with acute cholecystitis during the initial phase of the COVID-19 pandemic. Methods: CHOLECOVID is an international, multicentre, observational comparative study of patients admitted to hospital with acute cholecystitis during the COVID-19 pandemic. Data on management were collected for a 2-month study interval coincident with the WHO declaration of the SARS-CoV-2 pandemic and compared with an equivalent pre-pandemic time interval. Mediation analysis examined the influence of SARS-COV-2 infection on 30-day mortality. Results: This study collected data on 9783 patients with acute cholecystitis admitted to 247 hospitals across the world. The pandemic was associated with reduced availability of surgical workforce and operating facilities globally, a significant shift to worse severity of disease, and increased use of conservative management. There was a reduction (both absolute and proportionate) in the number of patients undergoing cholecystectomy from 3095 patients (56.2 per cent) pre-pandemic to 1998 patients (46.2 per cent) during the pandemic but there was no difference in 30-day all-cause mortality after cholecystectomy comparing the pre-pandemic interval with the pandemic (13 patients (0.4 per cent) pre-pandemic to 13 patients (0.6 per cent) pandemic; P = 0.355). In mediation analysis, an admission with acute cholecystitis during the pandemic was associated with a non-significant increased risk of death (OR 1.29, 95 per cent c.i. 0.93 to 1.79, P = 0.121). Conclusion: CHOLECOVID provides a unique overview of the treatment of patients with cholecystitis across the globe during the first months of the SARS-CoV-2 pandemic. The study highlights the need for system resilience in retention of elective surgical activity. Cholecystectomy was associated with a low risk of mortality and deferral of treatment results in an increase in avoidable morbidity that represents the non-COVID cost of this pandemic