Behavior of Tourists towards Conserving Underwater Cultural Heritage

Culture and heritage are one of the pull factors that attracts the tourists towards the destination. Tourists consume culture and heritage products in a different form such as experiencing the cuisines, participating in religious festivals, wearing cultural dresses, purchasing souvenirs which reflect culture and heritage of the destination, by visiting to heritage sites, museums and so on. Visiting land-based culture and heritage sites is quite common among tourists. Under the culture and heritage tag, underwater cultural water is getting more attention of the tourists since it give different, memorable and adventure experience. Underwater cultural heritage is nothing but traces of human existence having cultural, historical and archaeological character which have been partially or totally under water. It is essential to conserve and preserve the underwater cultural heritage since it holds the importance of past culture and tradition of the humans. The main objective of the study is to find out tourists’ awareness and importance of preserving underwater cultural heritage. The area of the study covers Gujarat and Tamil Nadu since each destination holds significant underwater cultural heritage value in India. The recommendations of the study will be useful to promote India has one of the prominent underwater cultural heritage destinatio

PIC: Protein Interactions Calculator

Interactions within a protein structure and interactions between proteins in an assembly are essential considerations in understanding molecular basis of stability and functions of proteins and their complexes. There are several weak and strong interactions that render stability to a protein structure or an assembly. Protein Interactions Calculator (PIC) is a server which, given the coordinate set of 3D structure of a protein or an assembly, computes various interactions such as disulphide bonds, interactions between hydrophobic residues, ionic interactions, hydrogen bonds, aromatic–aromatic interactions, aromatic–sulphur interactions and cation–π interactions within a protein or between proteins in a complex. Interactions are calculated on the basis of standard, published criteria. The identified interactions between residues can be visualized using a RasMol and Jmol interface. The advantage with PIC server is the easy availability of inter-residue interaction calculations in a single site. It also determines the accessible surface area and residue-depth, which is the distance of a residue from the surface of the protein. User can also recognize specific kind of interactions, such as apolar–apolar residue interactions or ionic interactions, that are formed between buried or exposed residues or near the surface or deep inside

Strong field gravitational lensing in scalar tensor theories

Strong field gravitational lensing in the Brans-Dicke theory has been studied. The deflection angle for photons passing very close to the photon sphere is estimated for the static spherically symmetric space-time of the theory and the position and magnification of the relativistic images are obtained. Modeling the super massive central object of the galaxy by the Brans-Dicke space-time, numerical values of different strong lensing observable are estimated. It is found that against the expectation there is no significant scalar field effect in the strong field observable lensing parameters. This observation raises question on the potentiality of the strong field lensing to discriminate different gravitational theories.Comment: 20 pages, accepted in Class. Quantum Grav., final versio

Chalcone-imidazolone conjugates induce apoptosis through DNA damage pathway by affecting telomeres

<p>Abstract</p> <p>Background</p> <p>Breast cancer is one of the most prevalent cancers in the world and more than one million women are diagnosed leading to 410,000 deaths every year. In our previous studies new chalcone-imidazolone conjugates were prepared and evaluated for their anticancer activity in a panel of 53 human tumor cell lines and the lead compounds identified were 6 and 8. This prompted us to investigate the mechanism of apoptotic event.</p> <p>Results</p> <p>Involvement of pro-apoptotic protein (Bax), active caspase-9 and cleavage of retinoblastoma protein was studied. Interestingly, the compounds caused upregulation of p21, check point proteins (Chk1, Chk2) and as well as their phosphorylated forms which are known to regulate the DNA damage pathway. Increased p53BP1 foci by immunolocalisation studies and TRF1 suggested the possible involvement of telomere and associated proteins in the apoptotic event. The telomeric protein such as TRF2 which is an important target for anticancer therapy against human breast cancer was extensively studied along with proteins involved in proper functioning of telomeres.</p> <p>Conclusions</p> <p>The apoptotic proteins such as Bax, active caspase-9 and cleaved RB are up-regulated in the compound treated cells revealing the apoptotic nature of the compounds. Down regulation of TRF2 and upregulation of the TRF1 as well as telomerase assay indicated the decrease in telomeric length revealing telomeric dysfunction and thereby controlling the rapid rate of cell proliferation. In summary, chalcone-imidazolone conjugates displayed significant DNA damage activity particularly at telomeres and caused both apoptosis and senescence-like growth arrest which suggested that these compounds have potential activity against breast carcinoma.</p