The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease.

The miR-17/92 cluster is among the best-studied microRNA clusters. Interest in the cluster and its members has been increasing steadily and the number of publications has grown exponentially since its discovery with more than 1000 articles published in 2012 alone. Originally found to be involved in tumorigenesis, research work in recent years has uncovered unexpected roles for its members in a wide variety of settings that include normal development, immune diseases, cardiovascular diseases, neurodegenerative diseases and aging. In light of its ever-increasing importance and ever-widening regulatory roles, we review here the latest body of knowledge on the cluster\u27s involvement in health and disease as well as provide a novel perspective on the full spectrum of protein-coding and non-coding transcripts that are likely regulated by its members

Electrochemical synthesis of hydroxy-thioxo-imidazole carboxylates: an experimental and theoretical study

We report here the facile synthesis of a new series of hydroxy-thioxo-imidazole carboxylates in good yields using the cyanomethyl anion as an electrogenerated base which is formed when dry acetonitrile is electrolyzed at constant current, followed by addition of different thioureas and diazirine-3,3-dicarboxylate. The mechanism of the reaction, NMR shifts and IR are discussed and compared to density functional theory calculations. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group

Allogeneic stem cell transplantation in AML with t(6;9)(p23;q34);DEK-NUP214 shows a favourable outcome when performed in first complete remission

Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is a poor-risk entity, commonly associated with FLT3-ITD (internal tandem duplication). Allogeneic stem-cell tranplantation (allo-SCT) is recommended, although studies analysing the outcome of allo-SCT in this setting are lacking. We selected 195 patients with t(6;9) AML, who received a first allo-SCT between 2000 and 2016 from the EBMT (European Society for Blood and Marrow Transplantation) registry. Disease status at time of allo-SCT was the strongest independent prognostic factor, with a two-year leukaemia-free survival and relapse incidence of 57% and 19% in patients in CR1 (first complete remission), 34% and 33% in CR2 (second complete remission), and 24% and 49% in patients not in remission, respectively (P < 0.001). This study, which represents the largest one available in t(6;9) AML, supports the recommendation to submit these patients to allo-SCT in CR1

Gas Transfer at Water Surfaces 2010

PrefaceSection 1: Interfacial Turbulence and Air-Water Scalar TransferJ. Hunt, S. Belcher, D. Stretch, S. Sajjadi, J. Clegg [1]S.A. Kitaigorodskii [13]S.A. Kitaigorodskii [29]Y. Toba [38]D. Turney, S. Banerjee [51]J.G. Janzen, H.E. Schulz, G.H. Jirka [65]S. Komori, R. Kurose, N. Takagaki, S. Ohtsubo, K. Iwano, K. Handa, S. Shimada [78]J. Beya, W. Peirson, M. Banner [90]S. Mizuno [104]M. Sanjou, I. Nezu, A. Toda [119]M. Sanjou, I. Nezu, Y. Akiya [129]K. Takehara, Y. Takano, T.G. Etoh [138]G. Caulliez [151]Section 2: Numerical Studies on Interfacial Turbulence and Scalar TransferL.-P. Hung, C.S. Garbe, W.-T. Tsai [165]A. E. Tejada-Martínez, C. Akan, C.E. Grosch [177]W.-T. Tsai, L.-P. Hung [193]P.G. Jayathilake, B.C. Khoo, Zhijun Tan [200]H.E. Schulz, A.L.A. Simões, J.G. Janzen [208]Section 3: Bubble-Mediated Scalar TransferD.P. Nicholson, S.R. Emerson, S. Khatiwala, R.C. Hamme [223]W. Mischler, R. Rocholz, B. Jähne [238]R. Patro, I. Leifer [249]K. Loh, K.B. Cheong, R. Uittenbogaard [262]N. Mori, S. Nakagawa [273]Section 4: Effects of Surfactants and Molecular Diffusivity on Turbulence and Scalar TransferA. Soloviev, S. Matt, M. Gilman, H. Hühnerfuss, B. Haus, D. Jeong, I. Savelyev, M. Donelan [285]S. Matt, A. Fujimura, A. Soloviev, S.H. Rhee [299]P. Vlahos, E.C. Monahan, B.J.Huebert, J.B. Edson [313]K.E. Richter, B. Jähne [322]X. Yan, W.L. Peirson, J.W. Walker, M.L. Banner [333]Section 5: Field MeasurementsP.M. Orton, C.J. Zappa, W.R. McGillis [343]U.Schimpf, L. Nagel, B. Jähne [358]C.L. McNeil, E.A. D'Asaro, J.A. Nystuen [368]D. Turk, B. Petelin, J.W. Book [377]M. Ribas-Ribas, A. Gómez-Parra, J.M. Forja [394]A. Rutgersson, A.-S. Smedman, E. Sahlée [406]H. Pettersson, K. K. Kahma, A. Rutgersson, M. Perttilä [420]Section 6: Global Air-Sea CO2 FluxesR. Wanninkhof, G.-H. Park, D.B. Chelton, C.M. Risien [431]N. Suzuki, S. Komori, M.A. Donelan [445]Y. Suzuki, Y. Toba [452]M.T. Johnson, C. Hughes, T.G. Bell, P.S. Liss [464]Section 7: Advanced Measuring TechniquesO. Tsukamoto, F. Kondo [485]R. Rocholz, S. Wanner, U. Schimpf, B. Jähne [496]B.C.G. Gonzalez, A.W. Lamon, J.G. Janzen, J.R. Campos, H.E. Schulz [507]E. Sahlée, K. Kahma, H. Pettersson, W.M. Drennan [516]D. Kiefhaber, R. Rocholz, G. Balschbach, B. Jähne [524]C.S. Garbe, A. Heinlein [535]Section 8: Environmental Problems Related to Air-Water Scalar TransferW.L. Peirson, G.A. Lee, C. Waite, P. Onesemo, G. Ninaus [545]Y.J. Choi, A. Abe, K. Takahashi [559]Y. Baba, K. Takahashi [571]R. Onishi, K. Takahashi, S. Komori [582][593]Turbulence and wave dynamics across gas-liquid interfacesThe calculation of the gas transfer between the ocean and atmosphereThe influence of wind wave breaking on the dissipation of the turbulent kinetic energy in the upper ocean and its dependence on the stage of wind wave developmentMarvellous self-consistency inherent in wind waves : Its origin and some items related to air-sea transfersNear surface turbulence and its relationship to air-water gas transfer ratesTurbulent gas flux measurements near the air-water interface in an oscillating-grid tankSensible and latent heat transfer across the air-water interface in wind-driven turbulenceRainfall-generated, near-surface turbulenceEffects of the mechanical wave propagating in the wind direction on currents and stresses across the air-water interfaceTurbulent transport in closed basin with wind-induced water wavesPIV measurements of Langumuir circulation generated by wind-induced water wavesStudy of vortices near wind wave surfaces using high-speed video camera and MLSWind wave breaking from micro to macroscaleValidation of Eddy-renewal model by numerical simulationMass transfer at the surface in LES of wind-driven shallow water flow with Langmuir circulationCharacteristics of gas-flux density distribution at the water surfacesNumerical simulation of interfacial mass transfer using the immersed interface methodStatistical approximations in gas-liquid mass transferAn inverse approach to estimate bubble-mediated air-sea gas flux from inert gas measurementsExperimental setup for the investigation of bubble mediated gas exchangeGas transfer velocity of single CO2 bubblesMass transfer across single bubblesAeration of surf zone breaking wavesModification of turbulence at the air-sea interface due to the presence of surfactants and implications for gas exchange. Part I: laboratory experimentModification of turbulence at the air-sea interface due to the presence of surfactants and implications for gas exchange. Part II: numerical simulationsWind-dependence of DMS transfer velocity: Comparison of model with recent southern ocean observationsA laboratory study of the Schmidt number dependency of air-water gas transferOn transitions in the Schmidt number dependency of low solubility gas transfer across air-water interfacesAn autonomous self-orienting catamaran (SOCa) for measuring air-water fluxes and forcingThe 2009 SOPRAN active thermography pilot experiment in the Baltic SeaObservations of air-sea exchange of N2 and O2 during the passage of Hurricane Gustav in the Gulf of Mexico during 2008The effect of high wind Bora events on water pCO2 and CO2 exchange in the coastal Northern AdriaticSeasonal sea-surface CO2 fugacity in the north-eastern shelf of the Gulf of Cádiz (southwest Iberian Peninsula)Including mixed layer convection when determining air-sea CO2 transfer velocityAir-sea carbon dioxide exchange during upwellingImpact of small-scale variability on air-sea CO2 fluxesThe effect of wind variability on the air-sea CO2 gas flux estimationFuture global mapping of air-sea CO2 flux by using wind and wind-wave distribution of CMIP3 multi-model ensembleA Rumsfeldian analysis of uncertainty in air-sea gas exchangeAccurate measurement of air-sea CO2 flux with open-path Eddy-CovarianceCombined Visualization of wind waves and water surface temperatureMicroscopic sensors for oxygen measurement at air-water interfaces and sediment biofilmsDamping of humidity fluctuations in a closed-path systemImproved Optical Instrument for the Measurement of Water Wave Statistics in the FieldFriction Velocity from Active Thermography and Shape AnalysisEvaporation mitigation by storage in rock and sandDevelopment of oil-spill simulation system based on the global ocean-atmosphere modelStructure variation dependence of tropical squall line on the tracer advection scheme in cloud-resolving modelHigh-resolution simulations for turbulent clouds developing over the oceAuthor Inde