Molecular mimicry of brucella melitensis epitopes in mouse and human arthritis

Brucellosis is one of the most frequent zoonosis worldwide. Infection is transferable to humans, where brucellosis is associated with high incidence of osteoarticular disease including osteomyelitis, arthritis and spondyloarthritis. Peripheral arthritis and sacroiliitis often develop in patients with no or low count of live Brucella. Recently, we demonstrated that mice develop spontaneous arthritis several weeks after acute infection when bacteria are already eradicated. We aim to decipher immune mechanism of the brucellosis-associated delayed arthritis that has not been elucidated so far

Molecular mimicry of brucella melitensis epitopes in mouse and human arthritis

Brucellosis is one of the most frequent zoonosis worldwide. Infection is transferable to humans, where brucellosis is associated with high incidence of osteoarticular disease including osteomyelitis, arthritis and spondyloarthritis. Peripheral arthritis and sacroiliitis often develop in patients with no or low count of live Brucella. Recently, we demonstrated that mice develop spontaneous arthritis several weeks after acute infection when bacteria are already eradicated. We aim to decipher immune mechanism of the brucellosis-associated delayed arthritis that has not been elucidated so far

Development of a multivalent vaccine against human herpesviruses

Current work demonstrates use of modern in silico tools for predicting peptide-based vaccine candidates. Four out of twenty one showed good HSV-2 neutralization activity. Further investigation is needed to obtain effective anti-HSV protective vaccine candidates. Future directions of this work will be further optimization of epitope selection strategy and use of other search algorithms

Serum collagen triple helix repeat-containing (CTHRC1) levels is associated with circulating stem cell factor and pro-inflammatory cytokines in rheumatoid arthritis

Everyday monitoring disease activity of chronic inflammatory diseases such as Rheumatoid Arthritis (RA) is a tempting approach for every patient for attaining personalized treatment strategies. Still underdeveloped area of RA biomarkers needs sensitive and specific analytes. CTHRC1 was found earlier expressed in activated synoviocytes and present in circulation that makes it potential valuable RA marker

Serum collagen triple helix repeat-containing (CTHRC1) levels is associated with circulating stem cell factor and pro-inflammatory cytokines in rheumatoid arthritis

Everyday monitoring disease activity of chronic inflammatory diseases such as Rheumatoid Arthritis (RA) is a tempting approach for every patient for attaining personalized treatment strategies. Still underdeveloped area of RA biomarkers needs sensitive and specific analytes. CTHRC1 was found earlier expressed in activated synoviocytes and present in circulation that makes it potential valuable RA marker

Elevated levels of plasma collagen priple helix repeat-containing (CTHRC1) protein correlates with increased granul ocytopoiesis and higher rheumatoid arthritis disease severity score

Monitoring and suppressing activity of the pathological granulating pannus tissue is essential for Rheumatoid Arthritis (RA) management. Synovial joints pain and tissue destruction is a derivative of the pannus activity. In a mouse model for RAwe found CTHRC1, a secreted and circulating protein, to be inducible in arthritis and correlated with the disease severity. We performed a clinical investigation to ascertain the role of CTHRC1 in the progression of the disease

Elevated levels of plasma collagen priple helix repeat-containing (CTHRC1) protein correlates with increased granul ocytopoiesis and higher rheumatoid arthritis disease severity score

Monitoring and suppressing activity of the pathological granulating pannus tissue is essential for Rheumatoid Arthritis (RA) management. Synovial joints pain and tissue destruction is a derivative of the pannus activity. In a mouse model for RAwe found CTHRC1, a secreted and circulating protein, to be inducible in arthritis and correlated with the disease severity. We performed a clinical investigation to ascertain the role of CTHRC1 in the progression of the disease