55 research outputs found

    Erratum: JASPAR 2018: update of the open-access database of transcription factor binding profiles and its web framework

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    JASPAR (http://jaspar.genereg.net) is an open-access database of curated, non-redundant transcription factor (TF)-binding profiles stored as position frequency matrices (PFMs) and TF flexible models (TFFMs) for TFs across multiple species in six taxonomic groups. In the 2018 release of JASPAR, the CORE collection has been expanded with 322 new PFMs (60 for vertebrates and 262 for plants) and 33 PFMs were updated (24 for vertebrates, 8 for plants and 1 for insects). These new profiles represent a 30% expansion compared to the 2016 release. In addition, we have introduced 316 TFFMs (95 for vertebrates, 218 for plants and 3 for insects). This release incorporates clusters of similar PFMs in each taxon and each TF class per taxon. The JASPAR 2018 CORE vertebrate collection of PFMs was used to predict TF-binding sites in the human genome. The predictions are made available to the scientific community through a UCSC Genome Browser track data hub. Finally, this update comes with a new web framework with an interactive and responsive user-interface, along with new features. All the underlying data can be retrieved programmatically using a RESTful API and through the JASPAR 2018 R/Bioconductor package

    Validar a guerra: a construção do regime de Expertise estratégica

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    This article is intended to contribute to the interpretative analysis of war. For that purpose, it investigates how some apparatuses located in strategic thinking help to make modern war a social practice considered both technically feasible and, at the same time, legitimate for soldiers. In so doing, it makes use of two different but closely related theoretical fields, pragmatic sociology (finding inspiration in the work of scholars such as Luc Boltanski, Nicolas Dodier and Francis Chateauraynaud), and the sociology of scientific knowledge (based mostly on the work of Bruno Latour). On the one hand, the sociology of scientific knowledge has developed a productive questioning of the construction of scientific facts that is particularly relevant to the present research. On the other hand, pragmatic sociology generates a compatible framework able to describe collective actions. The combination of both approaches allows the description of the formation of a strategic expertise regime that supports the technical legitimacy of the use of military force. Together, the sociology of scientific knowledge and pragmatic sociology bring a particularly relevant perspective to research pertaining to war.info:eu-repo/semantics/publishe

    Dokumentation fuer die Diagnosekicker

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    Available from TIB Hannover: RO 8093(221) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

    INVESTIGATION OF PASSIVE STABILIZATION-AND DIFFERENT TUNING SYSTEMS FOR TESLA CAVITIES WITH RESPECT TO CW OPERATION *

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    Abstract BESSY has planned a free-electron-laser that will be operated with TESLA type cavities at high Q-values in CW mode. These operating parameters imply a low cavity bandwidth and thus a high sensitivity towards ponderomotive oscillations, in particular microphonics. In the HoBiCaT facility, located at BESSY, we have tested various tuning systems (Saclay I, Saclay II) and compared their usability for CW operation. Furthermore, the impact of "Rossendorf"-type stabilization fixtures on the mechanical properties was investigated
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