33 research outputs found
Epilepsie et Renaissance
n° spécial (20) de la revue Epilepsies. Articles en français. Abstracts in Englis
Syndrome dysexécutif chez les sujets ayant une épilepsie myoclonique juvénile
TOURS-BU MĂ©decine (372612103) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
INTERET DE LA VIDEO-ELECTRO-ENCEPHALOGRAPHIE CHEZ 126 PATIENTS ADULTES ENREGISTRES CONSECUTIVEMENT AU CHU DE TOURS ENTRE 1994 ET 1999
TOURS-BU MĂ©decine (372612103) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
Utilisation de la mitoxantrone (Mx) dans la sclérose en plaques (expérience tourangelle)
TOURS-BU MĂ©decine (372612103) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
Are c.436G>A mutations less severe forms of Lafora disease? A case report
Lafora disease is a form of progressive myoclonic epilepsy with autosomal recessive transmission. Two genes have been identified so far: EPM2A and NHLRC1, and a third gene, concerning a pediatric onset subform, has been recently proposed. We report the case of a 23-year-old woman of Turkish origin with an unusual disease course. Clinical onset was at the age of 19Â years with tonicâclonic seizures, followed by cognitive impairment; EEG was in favor of Lafora disease, and the mutation c.436G>A (a missense mutation substituting aspartic acid in asparagine) in the NHLRC1 gene confirmed this diagnosis. After 5Â years of evolution, the patient only has moderate cognitive impairment. Some NHLRC1 mutations, particularly c.436G>A, are associated with a slower clinical course, but there are conflicting data in the literature. This case strengthens the hypothesis that the c.436G>A mutation in the NHLRC1 gene leads to less severe phenotypes and late-onset disease
Postictal psychosis, a cause of secondary affective psychosis: A clinical description study of 77 patients
International audienceObjective: Postictal psychosis (PIP) is a severe complication occurring at least in 2% of patients with epilepsy. Since the 19th century, psychiatrists have reported the specificity of PIP presentation, but descriptions did not clearly distinguish PIP from after-seizure delirium. This study aimed to provide a precise description of psychiatric signs occurring during PIP, and improve recognition of PIP.Methods: We performed a review of clinical descriptions available in literature (48 patients), that we gathered with a retrospective multicentric case series of patients from three French epilepsy units (29 patients). For each patient, we collected retrospectively the psychiatric signs, and epilepsy features.Results: We found a high prevalence of persecutory (67.5%) and religious (55.8%) delusions, with almost systematic hallucinations (83.1%) and frequent mood disturbances (76.6%), especially euphoria. Severe consequences were not negligible (other-directed assault in 20.8%, self-directed in 13.0%). The type of delusion was associated with mood symptoms (p = 0.017). Episode onset was mainly sudden/rapid (90.9%), its duration was mostly between one and 14 days (64.9%) and the response to antipsychotic medication was good. Disorder was recurrent in more than a half of the sample (57.1% of patients with at least 2 episodes).Conclusion: Considering our findings, PIP resembles more an affective psychosis, than a purely psychotic disorder. The presence of affective signs differentiates PIP from other psychotic comorbidities in epilepsy. Additionally, resemblance between PIP and psychotic manic episode might help to discuss links between epilepsy and bipolar disorder
âStop playing ping-pong! Epi-Psy, an effective discipline to promoteâ Comment on âPsychiatric comorbidities go unrecognized in patients with epilepsy: âYou see what you knowââ
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Exceptional stroke-like episodes in a patient with type I autosomal angioedema
SCOPUS: ar.jinfo:eu-repo/semantics/publishe