55-58 Basements of the New Engineering Building from the Pontificia Universidad Católica del Perú

Abstract Historical data of 222 Radon concentrations were collected in the building of Engineering PUCP recently built with eleven levels (eight on grades and three basements). The measurements were made in the three basement levels of the building. The first results of the history of 222 Radon concentrations in the basements of this building used as a parking lot are shown. The monitoring started the first week it was opened to the public. As nuclear track detectors we use the polymer cellulose nitrate (LR115 -Type 2). Changes in the concentration of 222 Radon registered, are linked into account aspects such as the use of exhaust extractors, increase in the number of vehicles, construction time and seasonal parameters. The results show adequate levels of 222 Radon concentration in all basements, the highest value is 97, 41 Bq/ m 3 at the deepest level, the third

Compassionate use of ruxolitinib in acute and chronic graft versus host disease refractory both to corticosteroids and extracorporeal photopheresis

Abstract Background Ruxolitinib is a potent inhibitor of JAK1/2 with proven efficacy in myelofibrosis. In recent years, research in graft versus host disease (GVHD) has revealed the role of activation of JAK pathways in alloreactive lymphocytes. Some reports have shown significant responses in refractory GVHD patients. Cases presentation In this report we present our experience in 8 patients with acute or chronic GVHD with refractoriness to steroids and extracorporeal photopheresis treated with ruxolitinib. Three patients had acute GVHD (1 pulmonary, 2 cutaneous, 1 multi-systemic) and 5 had chronic GVHD (3 cutaneous); 85% obtained an overall response and 50% a complete response with a tolerable toxicity profile. Conclusions In our series, Ruxolitinib was very active as a rescue therapy for patients with acute or chronic GVHD refractory to standard treatment