Direct spatial-temporal discrimination of modes in a photonic lightwave circuit using photon scanning tunnelling microscopy

Multi-mode photonic lightwave circuits (PLCs) provide new avenues for extending the performance of single mode systems. As an example, they can potentially provide increased bandwidth by multiplexing information into different waveguide modes[1]. For practical applications of multi-mode PLCs to be developed, a measurement technique is required to investigate detailed mode profiles and propagation constants in complex circuits. Photon scanning tunnelling microscopy (PSTM) provides a means of experimentally tracking the femtosecond inter-modal delays observed in PLCs with the ability to discriminate modes by their spatial profiles inside the waveguide

The Intimate Collaboration: Prints from Teaberry Press (Exhibition Catalogue)

Catalogue produced to document the exhibition The Intimate Collaboration: Prints from Teaberry Press. This exhibition documented the significant contributions to contemporary printmaking by Teaberry Press, an independent intaglio press owned by San Francisco-based artist, Tim Berry. Artists represented in The Intimate Collaboration were: William Allen, Terry Allen, Robert Arneson, Charles Arnoldi, John Baeder, Timothy Berry, Roger Brown, Squeak Carnwath, Christo, Gordon Cook, Robert Cottingham, Laddie Dill, James Ford, Rupert Garcia, Oliver Jackson, Jacob Kainen, Tom Knechtel, Don Nice, Jim Nutt, Claes Oldenburg, Deborah Orapallo, Sabina Ott, Ed Paschke, Philip Pearlstein, Ed Ruscha/Jim Ganzer, Irvin Tepper, Pat Steir, Anne Thornycroft, Jom Torlakson, Jack Tworkov, Beth Van Hoesen, and Willia, T. Wiley

Interleukin 6 plays a role in the migration of magnetically levitated mesenchymal stem cells spheroids

Mesenchymal stem cells (MSCs) reside quiescently within a specialised ‘niche’ environment in the bone marrow. However, following appropriate signalling cues, MSCs mobilise and migrate out from the niche, typically toward either sites of injury (a regenerative response) or toward primary tumours (an intrinsic homing response, which promotes MSCs as cellular vectors for therapeutic delivery). To date, very little is known about MSC mobilisation. By adopting a 3D MSC niche model, whereby MSC spheroids are cultured within a type I collagen gel, recent studies have highlighted interleukin-6 (IL-6) as a key cytokine involved in MSC migration. Herein, the ability of IL-6 to induce MSC migration was further investigated, and the key matrix metalloproteinases used to effect cell mobilisation were identified. Briefly, the impact of IL-6 on the MSC migration in a two-dimensional model systems was characterised—both visually using an Ibidi chemotaxis plate array (assessing for directional migration) and then via a standard 2D monolayer experiment, where cultured cells were challenged with IL-6 and extracted media tested using an Abcam Human MMP membrane antibody array. The 2D assay displayed a strong migratory response toward IL-6 and analysis of the membrane arrays data showed significant increases of several key MMPs. Both data sets indicated that IL-6 is important in MSC mobilisation and migration. We also investigated the impact of IL-6 induction on MSCs in 3D spheroid culture, serving as a simplistic model of the bone marrow niche, characterised by fluorescently tagged magnetic nanoparticles and identical membrane antibody arrays. An increase in MMP levels secreted by cells treated with 1 ng/mL IL-6 versus control conditions was noted in addition to migration of cells away from the central spheroid mass

Finance Training and Team Building: An Example of Finance Training Leading to Team Building

This research describes and evaluates how a finance training exercise led to readily identifiable team building among the participants in an executive development workshop initially targeted as a “Finance for the Non-Financial Executive “program. The finance exercise required the participants to make financial/operational tradeoffs in their own section of the firm in order to improve the return on assets for the corporation at large. The finance training workshop is used as a case study to provide observed behavioral inputs to evaluate and confirm that the finance training led to the team building. In order to confirm the emergence of team building, a collection of 12 published articles and texts on the subject of team building were reviewed and a master table was compiled containing all the authors’ named team characteristics. The workshop participant groups were observed and their individual and group behavior was compared to the team characteristics listed in the table. Their behavior matched all but two of the team characteristics listed in the lengthy table. Our conclusion was that the participant groups had, indeed, formed themselves into effective teams to accomplish their task of evaluating the financial/operational tradeoffs required to improve the return on assets for their firm. Their finance training led to team building

Increasing access to CBT for psychosis patients: a feasibility, randomised controlled trial evaluating brief, targeted CBT for distressing voices delivered by assistant psychologists (GiVE2)

Background: The National Institute for Health and Care Excellence (NICE) recommends that Cognitive Behaviour Therapy for psychosis (CBTp) is offered to all patients with a psychosis diagnosis. However, only a minority of psychosis patients in England and Wales are offered CBTp. This is attributable, in part, to the resource-intensive nature of CBTp. One response to this problem has been the development of CBTp in brief formats that are targeted at a single symptom and the mechanisms that maintain distress. We have developed a brief form of CBTp for distressing voices and reported preliminary evidence for its effectiveness when delivered by highly trained therapists (clinical psychologists). This study will investigate the delivery of this intervention by a cost-effective workforce of assistant psychologists following a brief training and evaluate the acceptability and feasibility of conducting a future, definitive, randomised controlled trial (RCT). Methods: This is a feasibility study for a pragmatic, three-arm, parallel-group, superiority 1:1:1 RCT comparing a Guided self-help CBT intervention for voices and treatment as usual (GiVE) to Supportive Counselling and treatment as usual (SC) to treatment as usual alone (TAU), recruiting across two sites, with blinded post-treatment and follow-up assessments. A process evaluation will quantitatively and qualitatively explore stakeholder experience. Discussion: Expected outcomes will include an assessment of the feasibility of conducting a definitive RCT, and data to inform the calculation of its sample size. If evidence from a subsequent, fully powered RCT suggests that GiVE is clinically and cost-effective when delivered by briefly trained assistant psychologists, CBTp offered in these less resource-intensive forms has the potential to generate benefits for individual patients (reduced distress, enhanced recovery and enhanced quality of life), service-level patient benefit (increased access to evidence-based psychological therapies) and economic benefits to the NHS (in terms of the reduced use of mental health inpatient services). Trial registration: Current Controlled Trials, ISRCTN registration number: 16166070. Registered on 5 February 2019

Geometric phases of scattering states in a ring geometry: adiabatic pumping in mesoscopic devices

Geometric phases of scattering states in a ring geometry are studied based on a variant of the adiabatic theorem. Three time scales, i.e., the adiabatic period, the system time and the dwell time, associated with adiabatic scattering in a ring geometry plays a crucial role in determining geometric phases, in contrast to only two time scales, i.e., the adiabatic period and the dwell time, in an open system. We derive a formula connecting the gauge invariant geometric phases acquired by time-reversed scattering states and the circulating (pumping) current. A numerical calculation shows that the effect of the geometric phases is observable in a nanoscale electronic device.Comment: 9 pages, 3 figure

Emerging therapeutic strategies for Fragile X Syndrome:Q&A

Understanding how best to treat aspects of Fragile X syndrome has the potential to improve the quality of life of affected individuals. Such an effective therapy has, as yet, remained elusive. In this article, we ask those researching or affected by Fragile X syndrome their views on the current state of research and from where they feel the most likely therapy may emerge

External cavity diode laser based upon an FBG in an integrated optical fiber platform

An external cavity diode laser is demonstrated using a Bragg grating written into a novel integrated optical fiber platform as the external cavity. The cavity is fabricated using flame-hydrolysis deposition to bond a photosensitive fiber to a silica-on-silicon wafer, and a grating written using direct UV-writing. The laser operates on a single mode at the acetylene P13 line (1532.83 nm) with 9 mW output power. The noise properties of the laser are characterized demonstrating low linewidth operation (< 14 kHz) and superior relative intensity noise characteristics when compared to a commercial tunable external cavity diode laser