1 research outputs found
Twoâphoton detection of organotin Schiff base complexes in cancer cells
The early detection of cancer cells and their visualization before and after surgery are essential for successful preâ and postâoperative disease management. Although fluorescence imaging is a sensitive and versatile tool that is finding increasing use in clinical applications, there is a lack of tumourâtargeting fluorophores. We report here a family of fluorescent Schiff base organotin dyes (1: Et2NâLâSnPh2, 2: Et2NâLâSnBu2, 3: MeOâLâSnPh2, 4: MeOâLâSnBu2, 5: HOâLâSnPh2, and 6: HOâLâSnBu2, where L=2âhydroxybenzylideneâ4âhydroxybenzhydrazine). In addition to oneâphotonâexcited fluorescence, efficient twoâphoton excitation was demonstrated in compounds 1â4. Two of the compounds (5 and 6), both with hydroxyl substituents, were capable of selective accumulation in HeLa cells, allowing differentiation from normal cells (periodontal ligament cells). Compounds 1 and 3 showed excellent cancer cell staining (HeLa) using twoâphoton bioimaging, which is promising for biomedicine applications