Envelhecimento populacional e suas implicações à gestão de marketing: Uma investigação no setor de academias de ginásticas

This work aims at analysing how gym academies are responding to the phenomenon of population ageing. Some research and studies have already pointed out specific needs of the elderly segment. However, this work intends to discuss the aging market and the supply of sports services and academies for individuals over 40 years old (the aging segment), who start to present physical needs and limitations associated with the aging process. The research approach is qualitative descriptive and the data was obtained through interviews with owners or staff of academies located in the metropolitan region of Campinas. The analysis of the results indicated the recognition of the potential of senior and mature consumers (between 40-59 years old). However none of the respondents had practices and services that exclusively met the needs of this group of consumers. In this context, the research sought to identify the factors and attributes most relevant to the supply of services of academies to the aging public, based on the recognition of the opportunity and the potential posed by this market. The study presents some contribution to the area of marketing services, as also adds relevant aspects to the development of businesses that seek this potential market.Este trabalho tem como objetivo analisar como as academias de ginástica estão respondendo ao fenômeno do envelhecimento populacional. Algumas pesquisas e estudos têm apontado necessidades específicas do segmento de mercado idoso. No entanto, buscou-se discutir o mercado envelhescente e a oferta de serviços esportivos e de academias para os indivíduos com mais de 40 anos, que começam a apresentar necessidades físicas e limitações associadas ao processo de envelhecimento. A abordagem da pesquisa é qualitativa descritiva e os dados foram obtidos por meio de entrevistas com proprietários ou funcionários de academias localizadas na Região Metropolitana de Campinas. A análise dos resultados indicou o reconhecimento do potencial dos consumidores mais velhos e envelhescentes, entretanto, nenhum dos entrevistados possui práticas e serviços que atendam exclusivamente às necessidades desse grupo de consumidores. Nesse contexto, a pesquisa buscou identificar os fatores e atributos mais relevantes para o fornecimento de serviços de academias para o público envelhescente, a partir do reconhecimento da oportunidade e do potencial desse mercado. O estudo apresenta algumas contribuições para a área de marketing de serviços, como também acrescenta aspectos relevantes para o desenvolvimento de negócios que buscam esse mercado potencial

Estimulação do enraizamento de estacas de seringueira (Hevea brasiliensis Muell. Arg.) pela aplicação de reguladores vegetais

Este ensaio foi conduzido com o objetivo de verificar o efeito do ácido indolbutírico (lBA), ácido naftalenacético (NAA), ácido indolilacético (IAA) e ácido succínico-2,2-dimetilhidrazida (SADH) no enraizamento de estacas de plantas jovens de seringueira. As estacas utilizadas foram retiradas da parte inferior das plantas e tiveram suas bases imersas por 1 hora em água, ou em soluções de IBA, NAA, IAA e SADH 2500 ppm. Os resultados obtidos 77 dias após o plantio mostraram que IBA promoveu maior porcentagem de enraizamento com relação ao controle. Porém, em relação ao brotamento das estacas, o tratamento com SADH mostrou-se superior ao controle. Os tratamentos com NAA e IAA revelaram resultados inferiores ao controle em relação ao número de estacas vivas, estacas com calos e estacas com brotações.This experiment was carried out to evaluate the effect of IBA, NAA, IAA and SADH on rooting of stem cuttings of Hevea brasilien sis. The stem cuttings were taken from the base of 18 months old plants, and then immersed in water or IBA, NAA, IAA and SADH solutions at concentration of 2500 ppm, by 1 hour.Pllants treated with IBA showed higher percentage of rooting compared with check treatment. SADH promoted increase in bud break. NAA and IAA reduced the number of cuttings alive, budded and with callus formation

Ação de estimulantes vegetais no desenvolvimento de pepino (Cucumis sativus L.)

This experiment was carried out to determine the effects of Triacontanol (0.5 g/l), Ergostim (2 ml/l), Atonik (0.5 ml/l) and Agrostemmin (1.25 g/l) on growth of cucumber plants 'Hibrido Caipira AG-207'. Cucumber plants were sprayed 7 days after sowing, under greenhouse conditions. Agrostemmin reduced plant height until 20 days after sowing. Atonik reduced plant height 27 days after sowing. At 34 days after cucumber sowing, plants treated with the plant stimulants not differed in height in relation to check treatment. Agrostemmin and Ergostim increased dry matter production of the lower part of the plant. The plant stimulants does not change the dry matter production of the apical region of cucumber plants.Observou-se o efeito de quatro estimulantes vegetais no desenvolvimento de plantas de pepino 'Hibrido Caipira AG-207', em condições de casa de vegetação, tendo a semeadura sido realizada em vasos de cerâmica e as plantas pulverizadas sete dias após a semeadura, com Triacontanol (1-hidroxitriacontano) na dosagem de 0,5 g/l, Ergostim (L-cisteina e ácido fólico + izometilentramina) 2 ml/ l, Atonik (mononitroguaiacol sódico e outros compostos nitrogenados aromáticos) 0,5 ml/l e Agrostemin (alantoina + triptofano +ácido fólico + ácido glutâmico + ácido alantóico + arcialanina + outros aminoácidos) 1,25 g/l. Através dos resultados obtidos verificou-se que nenhum dos estimulantes vegetais estudados promoveu aumento em altura das plantas de pepino, embora tenham mostrado uma tendência em provocar um aumento no peso da matéria seca

Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors.

The bone marrow tyrosine kinase in chromosome X (BMX) is pursued as a drug target because of its role in various pathophysiological processes. We designed BMX covalent inhibitors with single-digit nanomolar potency with unexploited topological pharmacophore patterns. Importantly, we reveal the first X-ray crystal structure of covalently inhibited BMX at Cys496, which displays key interactions with Lys445, responsible for hampering ATP catalysis and the DFG-out-like motif, typical of an inactive conformation. Molecular dynamic simulations also showed this interaction for two ligand/BMX complexes. Kinome selectivity profiling showed that the most potent compound is the strongest binder, displays intracellular target engagement in BMX-transfected cells with two-digit nanomolar inhibitory potency, and leads to BMX degradation PC3 in cells. The new inhibitors displayed anti-proliferative effects in androgen-receptor positive prostate cancer cells that where further increased when combined with known inhibitors of related signaling pathways, such as PI3K, AKT and Androgen Receptor. We expect these findings to guide development of new selective BMX therapeutic approaches

Search for supersymmetry in events with b-quark jets and missing transverse energy in pp collisions at 7 TeV

Results are presented from a search for physics beyond the standard model based on events with large missing transverse energy, at least three jets, and at least one, two, or three b-quark jets. The study is performed using a sample of proton-proton collision data collected at sqrt(s) = 7 TeV with the CMS detector at the LHC in 2011. The integrated luminosity of the sample is 4.98 inverse femtobarns. The observed number of events is found to be consistent with the standard model expectation, which is evaluated using control samples in the data. The results are used to constrain cross sections for the production of supersymmetric particles decaying to b-quark-enriched final states in the context of simplified model spectra.Comment: Submitted to Physical Review

Measurement of the underlying event activity in pp collisions at √s = 0.9 and 7 TeV with the novel jet-area/median approach

Open Access: This article is distributed under the terms of the Creative Commons Attribution License.-- Chatrchyan, S. et al.The first measurement of the charged component of the underlying event using the novel >jet-area/median> approach is presented for proton-proton collisions at centre-of-mass energies of 0.9 and 7 TeV. The data were recorded in 2010 with the CMS experiment at the LHC. A new observable, sensitive to soft particle production, is introduced and investigated inclusively and as a function of the event scale defined by the transverse momentum of the leading jet. Various phenomenological models are compared to data, with and without corrections for detector effects. None of the examined models describe the data satisfactorily. © 2012 SISSA.Acknowledge support from BMWF and FWF (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, and FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS (Colombia); MSES (Croatia); RPF (Cyprus); MoER, SF0690030s09 and ERDF (Estonia); Academy of Finland, MEC, and HIP (Finland); CEA and CNRS/IN2P3 (France);BMBF, DFG, and HGF (Germany); GSRT (Greece); OTKA and NKTH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); NRF and WCU (Korea); LAS (Lithuania); CINVESTAV, CONACYT, SEP, and UASLP-FAI (Mexico); MSI (New Zealand); PAEC (Pakistan); MSHE and NSC (Poland); FCT (Portugal); JINR (Armenia, Belarus, Georgia, Ukraine, Uzbekistan); MON, RosAtom, RAS and RFBR (Russia); MSTD (Serbia); SEIDI and CPAN (Spain); Swiss Funding Agencies (Switzerland); NSC (Taipei); ThEP, IPST and NECTEC (Thailand); TUBITAK and TAEK (Turkey); NASU (Ukraine); STFC (United Kingdom); DOE and NSF (USA). Individuals have received support from the Marie-Curie program and the European Research Council (European Union); the Leventis Foundation; the A. P. Sloan Foundation; the Alexander von Humboldt Foundation; the Austrian Science Fund (FWF); the Belgian Federal Science Policy Office; the Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture (FRIA-Belgium); the Agentschap voor Innovatie door Wetenschap en Technologie (IWTBelgium); the Ministry of Education, Youth and Sports (MEYS) of Czech Republic; the Council of Science and Industrial Research, India; the Compagnia di San Paolo (Torino); and the HOMING PLUS program of Foundation for Polish Science, cofinanced from European Union, Regional Development Fund.Peer Reviewe

Measurement of the prompt J/psi and psi(2S) polarizations in pp collisions at sqrt(s) = 7 TeV

The polarizations of prompt J/psi and psi(2S) mesons are measured in proton-proton collisions at sqrt(s) = 7 TeV, using a dimuon data sample collected by the CMS experiment at the LHC, corresponding to an integrated luminosity of 4.9 inverse femtobarns. The prompt J/psi and psi(2S) polarization parameters lambda[theta], lambda[phi], and lambda[theta, phi], as well as the frame-invariant quantity lambda(tilde), are measured from the dimuon decay angular distributions in three different polarization frames. The J/psi results are obtained in the transverse momentum range 14 < pt < 70 GeV, in the rapidity intervals abs(y) < 0.6 and 0.6 < abs(y) < 1.2. The corresponding psi(2S) results cover 14 < pt < 50 GeV and include a third rapidity bin, 1.2 < abs(y) < 1.5. No evidence of large transverse or longitudinal polarizations is seen in these kinematic regions, which extend much beyond those previously explored

Search for physics beyond the standard model in events with a Z boson, jets, and missing transverse energy in pp collisions at √s̅ = 7 TeV

Peer reviewe