Electrocortical components of anticipation and consumption in a monetary incentive delay task

In order to improve our understanding of the components that reflect functionally important processes during reward anticipation and consumption, we used principle components analyses (PCA) to separate and quantify averaged ERP data obtained from each stage of a modified monetary incentive delay (MID) task. Although a small number of recent ERP studies have reported that reward and loss cues potentiate ERPs during anticipation, action preparation, and consummatory stages of reward processing, these findings are inconsistent due to temporal and spatial overlap between the relevant electrophysiological components. Our results show three components following cue presentation are sensitive to incentive cues (N1, P3a, P3b). In contrast to previous research, reward‐related enhancement occurred only in the P3b, with earlier components more sensitive to break‐even and loss cues. During feedback anticipation, we observed a lateralized centroparietal negativity that was sensitive to response hand but not cue type. We also show that use of PCA on ERPs reflecting reward consumption successfully separates the reward positivity from the independently modulated feedback‐P3. Last, we observe for the first time a new reward consumption component: a late negativity distributed over the left frontal pole. This component appears to be sensitive to response hand, especially in the context of monetary gain. These results illustrate that the time course and sensitivities of electrophysiological activity that follows incentive cues do not follow a simple heuristic in which reward incentive cues produce enhanced activity at all stages and substages

Family Diabetes Camp Amidst COVID-19: A Community of Practice Model

Studies have found that youth are experiencing higher anxiety levels than prior to COVID-19, and youth with type 1 diabetes are at higher risk. Medical specialty camps are a type of camp that provide opportunities for youth with chronic illnesses to share common goals, increase socialization, improve camper well-being, and increase knowledge of diabetes management. The program evaluation sought to determine the impact of a campers’ outcomes of independence and perceived competence and familial impact during COVID-19. Over half the participants were at their first diabetes camp and 71% of the campers felt their perceived competence “increased a little bit” because of camp. Over 95% of parents felt that their participation in camp had increased their diabetes knowledge. Qualitative data from parents revealed 2 themes, camp as a meeting place and learning from others. The findings from this study demonstrate that medical specialty camps influence campers’ perceptions of independence and competence and that families play an important role in creating a community of practice

Effet du confinement de la pandémie à COVID-19 sur les besoins nutritionnels dans une population adulte active et chez des personnes en âge de retraite à Brazzaville, République du Congo: Impact of COVID-19 lockdown on nutritional status of active adults and retirement-age population in Brazzaville, Republic of Congo

Contexte & objectif. La dimension nutritionnelle du confinement instauré à l’occasion de la pandémie COVID-19 n’a pas encore était étudiée en milieu africain. La présente étude a pour objectifs d’identifier et analyser les caractéristiques nutritionnelles chez l’adulte actif et la personne âgée congolais pour dépister d’éventuelles carences. Méthodes. Dans une enquête transversale menée lors du second confinement entre avril et mai 2020, quelques ménages de Bacongo (Brazzaville, Congo) recrutés aléatoirement, ont été interviewés sur base d’un questionnaire de type alimentaire quantitatif. Elle portait sur la nature et la quantité des aliments consommés durant toute la journée, du lever au coucher. Les apports quotidiens ont été calculés, et rendus en termes de % d’énergie fournie respectivement par les glucides, les lipides et les protides ; ainsi que les oligo-éléments, et les vitamines (A, B et C). Résultats. La valeur nutritionnelle moyenne globale était de 2123,5 ± 494,5 Kcal, chez les 183 sujets inclus (107 adultes en activité professionnelle âgés entre 31 et 59 and et 76 personnes âgées de 66 à 80 ans). Spécifiquement, les besoins en glucides étaient couverts à hauteur de 81,5 %, tandis que ceux en protéines et en lipides étaient insuffisants, respectivement de l’ordre 33,5 g/j et 59,5 g/j en moyenne. Les apports en calcium, phosphore, et magnésium, étaient conformes aux normes recommandées, étant  respectivement : de 613,9 mg, 709,8 mg et 267,5 mg. Les apports en fer se situaient à la limite inférieure de la normale (7,7 mg) chez les sujets âgés de plus de 66 ans. Les apports en vitamines A et C étaient satisfaisants, tandis qu’un risque de carence était observé pour les vitamines B1 et B2, dans le groupe des sujets âgés de 31 à 59 ans (0,17 mg et 0,58 mg). Conclusion. Ces observations suggèrent un effet négatif du confinement dans le domaine nutritionnel, justifiant des stratégies adaptées de supplémentation alimentaire, en vue de renforcer les capacités immunitaires dans la population exposée. Context & objective. Nutritional impact of lockdown due to the COVID-19 pandemic has not yet been studied in African environment. This study aimed to analyze the nutritional characteristics of active adults and the elderly Congolese to screen for possible deficiencies. Methods. The cross-sectional survey was carried out between April and May 2020, during the 2nd Covid-19 lockdown. Few households in Bacongo (Brazzaville) were randomly recruited and interviewed, using a quantitative food-type questionnaire, adressing the nature and quantity of food consumed throughout the day. Daily intakes were measured and reported as percentage of energy supplied respectively by carbohydrates, lipids and proteins; as well as trace elements, and few vitamins. Results. The overall average nutritional value around 2123.5 ± 494.5 kcal reflects an insufficient intake; specifically for proteins (33,5g/d) and fat (59,5g/d) requirements, except for carbohydrates (81,5%). The intakes of calcium (613.9 mg), phosphorus (709,8 mg), and magnesium (267,5 mg) met the recommended standards. Iron intakes were at the lower limit of normal (7.7 mg) in subjects aged more than 66 yrs to. Vitamin intakes were relevant for vitamins A and C, while slightly deficient in subjects aged 31-59 yrs for vitamins B1 and B2. Conclusion. The present observations suggest a negative nutritional impact of lockdown, highlighting the need for targeted nutritional strategies of food supplementation

Use of GRADE for assessment of evidence about prognosis: rating confidence in estimates of event rates in broad categories of patients.

Summary pointsMain concepts- The Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) approach defines quality of evidence as confidence in effect estimates; this conceptualization can readily be applied to bodies of evidence estimating the risk of future of events (that is, prognosis) in broadly defined populations- In the field of prognosis, a body of observational evidence (including single arms of randomized controlled trials) begins as high quality evidence- The five domains GRADE considers in rating down confidence in estimates of treatment effect—that is, risk of bias, imprecision, inconsistency, indirectness, and publication bias—as well as the GRADE criteria for rating up quality, also apply to estimates of the risk of future of events from a body of prognostic studies- Applying these concepts to systematic reviews of prognostic studies provides a useful approach to determine confidence in estimates of overall prognosis in broad populationsLay summary- The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach to rating confidence in the results of research studies was initially developed for therapeutic questions- The GRADE approach considers study design (randomized trials versus non-randomized designs), risk of bias, inconsistency, imprecision, indirectness, and publication bias; size and trend in the effect are also considered- Observational studies looking at patients’ prognosis may provide robust estimates of the likelihood of undesirable or desirable outcomes in both treated and untreated patients- Patients will often find this information helpful in understanding the likely course of their disease, in planning their future, and in engaging in shared decision making with their healthcare providers- In a previous article, we examined factors that affect confidence in estimates of baseline risk (the risk of bad outcomes in untreated patients), providing examples of how this might influence the confidence in estimates of absolute treatment effect- This paper provides guidance for the use of the GRADE approach to determine confidence in estimates of future events in systematic reviews of prognostic studies in broad categories of patient

Long-term Observations in Acoustics - the Ocean Acoustic Observatory Federation

The Ocean Acoustic Observatory Federation (OAOF) includes several laboratories and universities: the Institute of Geophysics and Planetary Physics (IGPP) and the Marine Physical Laboratory (MPL) at the Scripps Institution of Oceanography, the Pacific Meteorological and Environmental Laboratory (PMEL) of NOAA, the Naval Postgraduate School (NPS), and the Applied Physics Laboratory at the University of Washington (UW/APL)

Nexus between constructs of social cognitive theory model and diabetes self-management among Ghanaian diabetic patients: A mediation modelling approach

The promotion of Diabetes Self-Management (DSM) practices, education, and support is vital to improving the care and wellbeing of diabetic patients. Identifying factors that affect DSM behaviours may be useful to promote healthy living among these patients. The study assessed the determinants of DSM practices among Type 2 diabetes mellitus (T2DM) patients using a model-based social cognitive theory (SCT). This cross-sectional study comprised 420 (T2DM) patients who visited the Diabetic Clinic of the Komfo Anokye Teaching Hospital (KATH), Kumasi-Ghana. Data was collected using self-structured questionnaires to obtain socio-demographic characteristics, T2DM-related knowledge, DSM practices, SCT constructs; beliefs in treatment effectiveness, level of self-efficacy, perceived family support, and healthcare provider-patient communication. Path analysis was used to determine direct and indirect effects of T2DM-related knowledge, perceived family support, and healthcare provider service on DSM practices with level of self-efficacy mediating the relationships, and beliefs in treatment effectiveness as moderators. The mean age of the participants was 53.1(SD = 11.4) years and the average disease duration of T2DM was 10 years. Most of the participants (65.5 %) had high ( \u3e 6.1mmol/L) fasting blood glucose (FBG) with an average of 6.93 (SD = 2.41). The path analysis model revealed that age (p = 0.176), gender (p = 0.901), and duration of T2DM (p = 0.119) did not confound the relationships between the SCT constructs and DSM specified in the model. A significant direct positive effect of family and friends’ support (Critical ratio (CR) = 5.279, p \u3c 0.001) on DSM was observed. Self-efficacy was a significant mediator in this relationship (CR = 4.833, p \u3c 0.001). There were significant conditional indirect effects (CIE) for knowledge of T2DM and family and friends’ support at medium and high levels of belief in treatment effectiveness (p \u3c 0.05) via level of self-efficacy on DSM practices. However, no evidence of moderated-mediation was observed for the exogenous variables on DSM. Diabetes-related knowledge of T2DM, family and friends’ support, level of self-efficacy, and belief in treatment effectiveness are crucial in DSM practices among Ghanaian T2DM patients. It is incumbent to consider these factors when designing interventions to improve DSM adherence

Recent Surveys in the Forests of Ulu Segama Malua, Sabah, Malaysia, Show That Orang-utans (P. p. morio) Can Be Maintained in Slightly Logged Forests

BACKGROUND: Today the majority of wild great ape populations are found outside of the network of protected areas in both Africa and Asia, therefore determining if these populations are able to survive in forests that are exploited for timber or other extractive uses and how this is managed, is paramount for their conservation. METHODOLOGY/PRINCIPAL FINDINGS: In 2007, the "Kinabatangan Orang-utan Conservation Project" (KOCP) conducted aerial and ground surveys of orang-utan (Pongo pygmaeus morio) nests in the commercial forest reserves of Ulu Segama Malua (USM) in eastern Sabah, Malaysian Borneo. Compared with previous estimates obtained in 2002, our recent data clearly shows that orang-utan populations can be maintained in forests that have been lightly and sustainably logged. However, forests that are heavily logged or subjected to fast, successive coupes that follow conventional extraction methods, exhibit a decline in orang-utan numbers which will eventually result in localized extinction (the rapid extraction of more than 100 m(3) ha(-1) of timber led to the crash of one of the surveyed sub-populations). Nest distribution in the forests of USM indicates that orang-utans leave areas undergoing active disturbance and take momentarily refuge in surrounding forests that are free of human activity, even if these forests are located above 500 m asl. Displaced individuals will then recolonize the old-logged areas after a period of time, depending on availability of food sources in the regenerating areas. CONCLUSION/SIGNIFICANCE: These results indicate that diligent planning prior to timber extraction and the implementation of reduced-impact logging practices can potentially be compatible with great ape conservation

Economic Analysis of Knowledge: The History of Thought and the Central Themes

Following the development of knowledge economies, there has been a rapid expansion of economic analysis of knowledge, both in the context of technological knowledge in particular and the decision theory in general. This paper surveys this literature by identifying the main themes and contributions and outlines the future prospects of the discipline. The wide scope of knowledge related questions in terms of applicability and alternative approaches has led to the fragmentation of research. Nevertheless, one can identify a continuing tradition which analyses various aspects of the generation, dissemination and use of knowledge in the economy

The Science Performance of JWST as Characterized in Commissioning

This paper characterizes the actual science performance of the James Webb Space Telescope (JWST), as determined from the six month commissioning period. We summarize the performance of the spacecraft, telescope, science instruments, and ground system, with an emphasis on differences from pre-launch expectations. Commissioning has made clear that JWST is fully capable of achieving the discoveries for which it was built. Moreover, almost across the board, the science performance of JWST is better than expected; in most cases, JWST will go deeper faster than expected. The telescope and instrument suite have demonstrated the sensitivity, stability, image quality, and spectral range that are necessary to transform our understanding of the cosmos through observations spanning from near-earth asteroids to the most distant galaxies.Comment: 5th version as accepted to PASP; 31 pages, 18 figures; https://iopscience.iop.org/article/10.1088/1538-3873/acb29