PROPHYLACTIC EVALUATION OF SHOULDER PROPRIOCEPTION IN ELITE SWIMMERS

It is suggested that poor shoulder proprioception contributes to shoulder pain in swimmers. However, there is a lack of studies describing the measurement method for shoulder proprioception. The purposes of this preliminary study was to investigate the scapular position depending on arm scaption as a first step in the development of a measurement method for three-dimensional shoulder proprioception. An asymptomatic young adults participated in this study. His scapular rotation were measured as a function of arm position during scaption in two consecutive days. The results showed that scapular rotations are not a reproducible function of humerus elevation. Those findings suggested that the assessement of shoulder proprioception should rely on the evaluation of both gleno-humeral and scapulo-thoracic joints to be valid

Study on the representativeness o the social partner organisations in the professional football players sector

A portada: Université catholique de Louvain. Institut des sciences du travailResearch project conducted on behalf of the Employment and Social Affairs DG of the European CommissionThe aim of the report is to produce a study that sets out both brief descriptions of the way that social dialogue functions in the countries concerned, and descriptions of the various workers' and employers' organisations involved in social dialogue at sector level. This study may be seen as a tool to help understand these quantitative and qualitative factors. It will also make it possible to understand the various systems of industrial relations in different countries, and to introduce the actors involved in social dialogue

Study on the representativeness of the social partner organisations in the extractive industry

Tipus de projecte: Projecte europeuA portada: Universite catholique de Louvain. Institut de sciences du travailResearch project conducted on behalf of the Employment and Social Affairs DG of the European Commissio

Study on the representativeness of the social partner organisations in the extractive industry

Tipus de projecte: Projecte europeuA portada: Universite catholique de Louvain. Institut de sciences du travailResearch project conducted on behalf of the Employment and Social Affairs DG of the European Commissio

Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene-Driven Myeloid Leukemia.

Fusion oncogenes are prevalent in several pediatric cancers, yet little is known about the specific associations between age and phenotype. We observed that fusion oncogenes, such as ETO2-GLIS2, are associated with acute megakaryoblastic or other myeloid leukemia subtypes in an age-dependent manner. Analysis of a novel inducible transgenic mouse model showed that ETO2-GLIS2 expression in fetal hematopoietic stem cells induced rapid megakaryoblastic leukemia whereas expression in adult bone marrow hematopoietic stem cells resulted in a shift toward myeloid transformation with a strikingly delayed in vivo leukemogenic potential. Chromatin accessibility and single-cell transcriptome analyses indicate ontogeny-dependent intrinsic and ETO2-GLIS2-induced differences in the activities of key transcription factors, including ERG, SPI1, GATA1, and CEBPA. Importantly, switching off the fusion oncogene restored terminal differentiation of the leukemic blasts. Together, these data show that aggressiveness and phenotypes in pediatric acute myeloid leukemia result from an ontogeny-related differential susceptibility to transformation by fusion oncogenes. SIGNIFICANCE: This work demonstrates that the clinical phenotype of pediatric acute myeloid leukemia is determined by ontogeny-dependent susceptibility for transformation by oncogenic fusion genes. The phenotype is maintained by potentially reversible alteration of key transcription factors, indicating that targeting of the fusions may overcome the differentiation blockage and revert the leukemic state.See related commentary by Cruz Hernandez and Vyas, p. 1653.This article is highlighted in the In This Issue feature, p. 1631

Genome analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea

Sclerotinia sclerotiorum and Botrytis cinerea are closely related necrotrophic plant pathogenic fungi notable for their wide host ranges and environmental persistence. These attributes have made these species models for understanding the complexity of necrotrophic, broad host-range pathogenicity. Despite their similarities, the two species differ in mating behaviour and the ability to produce asexual spores. We have sequenced the genomes of one strain of S. sclerotiorum and two strains of B. cinerea. The comparative analysis of these genomes relative to one another and to other sequenced fungal genomes is provided here. Their 38–39 Mb genomes include 11,860–14,270 predicted genes, which share 83% amino acid identity on average between the two species. We have mapped the S. sclerotiorum assembly to 16 chromosomes and found large-scale co-linearity with the B. cinerea genomes. Seven percent of the S. sclerotiorum genome comprises transposable elements compared t

Développer la médiation documentaire numérique

Depuis quelques années, les bibliothèques investissent fortement l'Internet : catalogues en ligne, sites Web devenant peu à peu des portails de services, blogs et réseaux sociaux. Si l'objectif est bien d'être présent dans l'univers numérique des usagers existants ou potentiels, les bibliothèques, aussi bien universitaires que de lecture publique, doivent garder leur spécificité sous peine d'être noyées dans le flot général. L'un des axes de travail pour ce faire est de transposer en ligne la médiation documentaire, c'est-à-dire repenser pour l'Internet tous les moyens à mettre en œuvre pour favoriser la rencontre d'un lecteur avec les documents susceptibles de l'intéresser ou de lui ouvrir de nouveaux horizons. L'ouvrage traite de ce nouvel enjeu en proposant d'une part, un cadre général sur la médiation documentaire numérique (quelle politique documentaire favoriser ? Comment scénariser son catalogue, médiatiser un fonds patrimonial ou de jeux vidéo ? Comment définir son projet et accompagner les équipes ?) et d'autre part, des exemples concrets destinés à servir d'inspiration pour améliorer ou se lancer dans ce continent en pleine construction (quels contenus produire ? Quels outils utiliser ? Comment rédiger un billet de blog, un article de magazine en ligne, des coups de cœurs 2.0 ?). Coordonné par Xavier Galaup, directeur-adjoint de la médiathèque départementale du Haut-Rhin, ce volume collectif, qui réunit des auteurs d'horizons divers (universitaire, bibliothécaire et libraire), s'adresse à tous les acteurs des domaines de la culture et de l'éducation

Opportunities, barriers, and recommendations in down syndrome research

Recent advances in medical care have increased life expectancy and improved the quality of life for people with Down syndrome (DS). These advances are the result of both pre-clinical and clinical research but much about DS is still poorly understood. In 2020, the NIH announced their plan to update their DS research plan and requested input from the scientific and advocacy community. The National Down Syndrome Society (NDSS) and the LuMind IDSC Foundation worked together with scientific and medical experts to develop recommendations for the NIH research plan. NDSS and LuMind IDSC assembled over 50 experts across multiple disciplines and organized them in eleven working groups focused on specific issues for people with DS. This review article summarizes the research gaps and recommendations that have the potential to improve the health and quality of life for people with DS within the next decade. This review highlights many of the scientific gaps that exist in DS research. Based on these gaps, a multidisciplinary group of DS experts has made recommendations to advance DS research. This paper may also aid policymakers and the DS community to build a comprehensive national DS research strategy

Staphylococcus aureus infective endocarditis versus bacteremia strains: Subtle genetic differences at stake

AbstractInfective endocarditis (IE)(1) is a severe condition complicating 10–25% of Staphylococcus aureus bacteremia. Although host-related IE risk factors have been identified, the involvement of bacterial features in IE complication is still unclear. We characterized strictly defined IE and bacteremia isolates and searched for discriminant features. S. aureus isolates causing community-acquired, definite native-valve IE (n=72) and bacteremia (n=54) were collected prospectively as part of a French multicenter cohort. Phenotypic traits previously reported or hypothesized to be involved in staphylococcal IE pathogenesis were tested. In parallel, the genotypic profiles of all isolates, obtained by microarray, were analyzed by discriminant analysis of principal components (DAPC)(2). No significant difference was observed between IE and bacteremia strains, regarding either phenotypic or genotypic univariate analyses. However, the multivariate statistical tool DAPC, applied on microarray data, segregated IE and bacteremia isolates: IE isolates were correctly reassigned as such in 80.6% of the cases (C-statistic 0.83, P<0.001). The performance of this model was confirmed with an independent French collection IE and bacteremia isolates (78.8% reassignment, C-statistic 0.65, P<0.01). Finally, a simple linear discriminant function based on a subset of 8 genetic markers retained valuable performance both in study collection (86.1%, P<0.001) and in the independent validation collection (81.8%, P<0.01). We here show that community-acquired IE and bacteremia S. aureus isolates are genetically distinct based on subtle combinations of genetic markers. This finding provides the proof of concept that bacterial characteristics may contribute to the occurrence of IE in patients with S. aureus bacteremia