Struktur-Wirkungs-Beziehungen anhand von Epoxiden in Saeugerzell-Genotoxitaets-Tests

Studies with mammalian V79-cells showed that for some sub-groups of epoxides a close quantitative relationship exists between the genotoxic potency and the chemical structure. This relationship is well described by the alkylation rate of NBP by these substances. But it is also shown that alkylation of NBP by epoxides is not a good parameter for a more general prediction of genotoxicity in mammalian cells. The predictibility of genotoxicity is enhanced when also the water/octanol partition coefficient is considered. On the other hand, a quantitative prediction for chiral epoxides is not possible because enantiomers do not differ in these parameters, whereas they differ in their biological effects. Furthermore, these effects were different between bacteria and mammalian cells. Further studies have to show which biological mechanisms are responsible for these different effects of enantiomers. (orig.)SIGLEAvailable from TIB Hannover: RN 8908(92-047) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Umwelt, Naturschutz und Reaktorsicherheit, Bonn (Germany)DEGerman