10 research outputs found
Quality Improvement: A guide for services
This guide provides information for clinicians from organisations and services participating in PCOC to use their reports and the suite of PCOC quality improvement tools for continuous improvement, and to demonstrate improvement in patient and family/carer outcomes
Progesterone Response in Neonatal Endometrium is Key to Future Reproductive Health in Adolescents
Interaction of haloperidol with human serum albumin and effect of metal ions on the binding
In vitro and in vivo evaluation of the genotoxic and antigenotoxic potential of the major Chios mastic water constituents
Analgesic Effect of Acupuncture Is Mediated via Inhibition of JNK Activation in Astrocytes after Spinal Cord Injury
Neuropathic Pain and Spinal Cord Injury: Phenotypes and Pharmacological Management
Chronic neuropathic pain is a complicated condition after a spinal cord injury (SCI) that often has a lifelong and significant negative impact on life after the injury; therefore, improved pain management is considered a significant and unmet need. Neuropathic pain mechanisms are heterogeneous and the difficulty in determining their individual contribution to specific pain types may contribute to poor treatment outcomes in this population. Thus, identifying human neuropathic pain phenotypes based on pain symptoms, somatosensory changes, or cognitive and psychosocial factors that reflect specific spinal cord or brain mechanisms of neuropathic pain is an important goal. Once a pain phenotype can be reliably replicated, its relationship with biomarkers and clinical treatment outcomes can be analyzed, and thereby facilitate translational research and further the mechanistic understanding of individual differences in the pain experience and in clinical trial outcomes. The present article will discuss clinical aspects of SCI-related neuropathic pain, neuropathic pain phenotypes, pain mechanisms, potential biomarkers and pharmacological interventions, and progress regarding how defining neuropathic pain phenotypes may lead to more targeted treatments for these difficult pain conditions