Search for Supersymmetric Dark Matter with Superfluid He3 (MACHe3)

MACHe3 (MAtrix of Cells of superfluid He3) is a project of a new detector for direct Dark Matter search, using superfluid He3 as a sensitive medium. This paper presents a phenomenological study done with the DarkSUSY code, in order to investigate the discovery potential of this project of detector, as well as its complementarity with existing and planned devices.Comment: 15 pages, 5 figures, submitted to Phys. Letters B, minor changes in the tex

Gamma-ray and Radio Constraints of High Positron Rate Dark Matter Models Annihilating into New Light Particles

The possibility of explaining the positron and electron excess recently found by the PAMELA and ATIC collaborations in terms of dark matter (DM) annihilation has attracted considerable attention. Models surviving bounds from, e.g, antiproton production generally fall into two classes, where either DM annihilates directly with a large branching fraction into light leptons, or, as in the recent models of Arkani-Hamed et al., and of Nomura and Thaler, the annihilation gives low-mass (pseudo)scalars or vectors $\phi$ which then decay into $\mu^+\mu^-$ or $e^+e^-$. While the constraints on the first kind of models have recently been treated by several authors, we study here specifically models of the second type which rely on an efficient Sommerfeld enhancement in order to obtain the necessary boost in the annihilation cross section. We compute the photon flux generated by QED radiative corrections to the decay of $\phi$ and show that this indeed gives a rather spectacular broad peak in $E^2d\sigma/dE$, that for these extreme values of the cross section violate gamma-ray observations of the Galactic center for DM density profiles steeper than that of Navarro, Frenk and White. The most stringent constraint comes from the comparison of the predicted synchrotron radiation in the central part of the Galaxy with radio observations of Sgr A*. For the most commonly adopted DM profiles, the models that provide a good fit to the PAMELA and ATIC data are ruled out, unless there are physical processes that boost the local anti-matter fluxes more than one order of magnitude, while not affecting the gamma-ray or radio fluxes.Comment: 5 pages, 3 figures, matches published versio

Human resources for control of tuberculosis and HIV-associated tuberculosis.

The global targets for tuberculosis (TB) control were postponed from 2000 to 2005, but on current evidence a further postponement may be necessary. Of the constraints preventing these targets being met, the primary one appears to be the lack of adequately trained and qualified staff. This paper outlines: 1) the human resources and skills for global TB and human immunodeficiency virus (HIV) TB control, including the human resources for implementing the DOTS strategy, the additional human resources for implementing joint HIV-TB control strategies and what is known about human resource gaps at global level; 2) the attempts to quantify human resource gaps by focusing on a small country in sub-Saharan Africa, Malawi; and 3) the main constraints to human resources and their possible solutions, under six main headings: human resource planning; production of human resources; distribution of the work-force; motivation and staff retention; quality of existing staff; and the effect of HIV/AIDS. We recommend an urgent shift in thinking about the human resource paradigm, and exhort international policy makers and the donor community to make a concerted effort to bridge the current gaps by investing for real change

Two photon annihilation of Kaluza-Klein dark matter

We investigate the fermionic one-loop cross section for the two photon annihilation of Kaluza-Klein (KK) dark matter particles in a model of universal extra dimensions (UED). This process gives a nearly mono-energetic gamma-ray line with energy equal to the KK dark matter particle mass. We find that the cross section is large enough that if a continuum signature is detected, the energy distribution of gamma-rays should end at the particle mass with a peak that is visible for an energy resolution of the detector at the percent level. This would give an unmistakable signature of a dark matter origin of the gamma-rays, and a unique determination of the dark matter particle mass, which in the case studied should be around 800 GeV. Unlike the situation for supersymmetric models where the two-gamma peak may or may not be visible depending on parameters, this feature seems to be quite robust in UED models, and should be similar in other models where annihilation into fermions is not helicity suppressed. The observability of the signal still depends on largely unknown astrophysical parameters related to the structure of the dark matter halo. If the dark matter near the galactic center is adiabatically contracted by the central star cluster, or if the dark matter halo has substructure surviving tidal effects, prospects for detection look promising.Comment: 17 pages, 3 figures; slightly revised versio

Dark matter annihilation at the galactic center

If cold dark matter is present at the galactic center, as in current models of the dark halo, it is accreted by the central black hole into a dense spike. Particle dark matter then annihilates strongly inside the spike, making it a compact source of photons, electrons, positrons, protons, antiprotons, and neutrinos. The spike luminosity depends on the density profile of the inner halo: halos with finite cores have unnoticeable spikes, while halos with inner cusps may have spikes so bright that the absence of a detected neutrino signal from the galactic center already places interesting upper limits on the density slope of the inner halo. Future neutrino telescopes observing the galactic center could probe the inner structure of the dark halo, or indirectly find the nature of dark matter.Comment: 4 pages, 5 figure

Diffuse inverse Compton and synchrotron emission from dark matter annihilations in galactic satellites

Annihilating dark matter particles produce roughly as much power in electrons and positrons as in gamma ray photons. The charged particles lose essentially all of their energy to inverse Compton and synchrotron processes in the galactic environment. We discuss the diffuse signature of dark matter annihilations in satellites of the Milky Way (which may be optically dark with few or no stars), providing a tail of emission trailing the satellite in its orbit. Inverse Compton processes provide X-rays and gamma rays, and synchrotron emission at radio wavelengths might be seen. We discuss the possibility of detecting these signals with current and future observations, in particular EGRET and GLAST for the gamma rays.Comment: 13 pages, 5 figure

Antimatter and Gamma-rays from Dark Matter Annihilation

A brief review of the indirect detection signatures of dark matter is given. In particular, detection methods of dark matter particle annihilation to antimatter and gamma-rays are reviewed. With the GLAST satellite soon to be launched, a crucial window in the energy range of a few GeV up to 300 GeV will open. The good angular and energy resolution of the instrument means that structures predicted by cold dark matter models can be searched for. Large, currently planned ground-based imaging Cherenkov telescope arrays, may further improve the limits, or discover a signal, if the current understanding of halo dark matter structure is correct.Comment: 7p, one fig., invited talk at TAUP 2007, Sendai, Japan, to appear in the Proceeding

GL2xGSp2 L-values and Hecke eigenvalue congruences

We find experimental examples of congruences of Hecke eigenvalues between automorphic representations of groups such as GSp2(A), SO(4, 3)(A) and SO(5, 4)(A), where the prime modulus should, for various reasons, appear in the algebraic part of a critical “tensor-product” L-value associated to cuspidal automorphic representations of GL2(A) and GSp2 (A). Using special techniques for evaluating L-functions with few known coefficients, we compute sufficiently good approximations to detect the anticipated prime divisors

Paclitaxel, Epirubicin and Capecitabine (TEX) as First-Line Treatment for Metastatic Breast Cancer: a Pilot Phase I/II Feasibility Study

Thirteen patients with untreated metastatic breast cancer received epirubicin 60 mg/m2, paclitaxel 155 mg/m2 (both day 1) and capecitabine 665 mg/m2 twice daily (days 1–14) every 21 days, with intra-patient dose escalation/reduction. Grade 3/4 events were infrequent. Nine patients (69%) achieved an objective response. Median time to progression and overall survival were 6.6 and 23.5 months, respectively