147 research outputs found
The FERRUM project: laboratory-measured transition probabilities for Cr II
Aims: We measure transition probabilities for Cr II transitions from the z
^4H_J, z ^2D_J, y ^4F_J, and y ^4G_J levels in the energy range 63000 to 68000
cm^{-1}. Methods: Radiative lifetimes were measured using time-resolved
laser-induced fluorescence from a laser-produced plasma. In addition, branching
fractions were determined from intensity-calibrated spectra recorded with a UV
Fourier transform spectrometer. The branching fractions and radiative lifetimes
were combined to yield accurate transition probabilities and oscillator
strengths. Results: We present laboratory measured transition probabilities for
145 Cr II lines and radiative lifetimes for 14 Cr II levels. The
laboratory-measured transition probabilities are compared to the values from
semi-empirical calculations and laboratory measurements in the literature.Comment: 13 pages. Accepted for publication in A&
Original Article Dietary Soy Supplement on Fibromyalgia Symptoms: A Randomized, Double-Blind, Placebo-Controlled, Early Phase Trial
Most patients with fibromyalgia use complementary and alternative medicine (CAM). Properly designed controlled trials are necessary to assess the effectiveness of these practices. This study was a randomized, double-blind, placebo-controlled, early phase trial. Fifty patients seen at a fibromyalgia outpatient treatment program were randomly assigned to a daily soy or placebo (casein) shake. Outcome measures were scores of the Fibromyalgia Impact Questionnaire (FIQ) and the Center for Epidemiologic Studies Depression Scale (CES-D) at baseline and after 6 weeks of intervention. Analysis was with standard statistics based on the null hypothesis, and separation test for early phase CAM comparative trials. Twenty-eight patients completed the study. Use of standard statistics with intent-to-treat analysis showed that total FIQ scores decreased by 14% in the soy group (P = .02) and by 18% in the placebo group (P < .001). The difference in change in scores between the groups was not significant (P = .16). With the same analysis, CES-D scores decreased in the soy group by 16% (P = .004) and in the placebo group by 15% (P = .05). The change in scores was similar in the groups (P = .83). Results of statistical analysis using the separation test and intent-to-treat analysis revealed no benefit of soy compared with placebo. Shakes that contain soy and shakes that contain casein, when combined with a multidisciplinary fibromyalgia treatment program, provide a decrease in fibromyalgia symptoms. Separation between the effects of soy and casein (control) shakes did not favor the intervention. Therefore, large-sample studies using soy for patients with fibromyalgia are probably not indicated
A filled duration illusion in music: Effects of metrical subdivision on the perception and production of beat tempo.
This study replicates and extends previous findings suggesting that metrical
subdivision slows the perceived beat tempo (Repp, 2008). Here, musically trained participants produced the
subdivisions themselves and were found to speed up, thus compensating for the
perceived slowing. This was shown in a synchronization-continuation paradigm
(Experiment 1) and in a reproduction task (Experiment 2a). Participants also
judged the tempo of a subdivided sequence as being slower than that of a
preceding simple beat sequence (Experiment 2b). Experiment 2 also included
nonmusician participants, with similar results. Tempo measurements of famous
pianists’ recordings of two variation movements from Beethoven sonatas revealed
a strong tendency to play the first variation (subdivided beats) faster than the
theme (mostly simple beats). A similar tendency was found in musicians’
laboratory performances of a simple theme and variations, despite instruc-tions
to keep the tempo constant (Experiment 3a). When playing melodic sequences in
which only one of three beats per measure was subdivided, musicians tended to
play these beats faster and to perceive them as longer than adjacent beats, and
they played the whole sequence faster than a sequence without any subdivisions
(Experiments 3b and 3c). The results amply demonstrate a filled duration
illusion in rhythm perception and music performance: Intervals
containing events seem longer than empty intervals and thus must be shortened to
be perceived as equal in duration
Language development after cochlear implantation: an epigenetic model
Growing evidence supports the notion that dynamic gene expression, subject to epigenetic control, organizes multiple influences to enable a child to learn to listen and to talk. Here, we review neurobiological and genetic influences on spoken language development in the context of results of a longitudinal trial of cochlear implantation of young children with severe to profound sensorineural hearing loss in the Childhood Development after Cochlear Implantation study. We specifically examine the results of cochlear implantation in participants who were congenitally deaf (N = 116). Prior to intervention, these participants were subject to naturally imposed constraints in sensory (acoustic–phonologic) inputs during critical phases of development when spoken language skills are typically achieved rapidly. Their candidacy for a cochlear implant was prompted by delays (n = 20) or an essential absence of spoken language acquisition (n = 96). Observations thus present an opportunity to evaluate the impact of factors that influence the emergence of spoken language, particularly in the context of hearing restoration in sensitive periods for language acquisition. Outcomes demonstrate considerable variation in spoken language learning, although significant advantages exist for the congenitally deaf children implanted prior to 18 months of age. While age at implantation carries high predictive value in forecasting performance on measures of spoken language, several factors show significant association, particularly those related to parent–child interactions. Importantly, the significance of environmental variables in their predictive value for language development varies with age at implantation. These observations are considered in the context of an epigenetic model in which dynamic genomic expression can modulate aspects of auditory learning, offering insights into factors that can influence a child’s acquisition of spoken language after cochlear implantation. Increased understanding of these interactions could lead to targeted interventions that interact with the epigenome to influence language outcomes with intervention, particularly in periods in which development is subject to time-sensitive experience
Acquired and congenital disorders of sung performance: A review.
Many believe that the majority of people are unable to carry a tune. Yet, this
widespread idea underestimates the singing abilities of the layman. Most
occasional singers can sing in tune and in time, provided that they perform at a
slow tempo. Here we characterize proficient singing in the general population
and identify its neuronal underpinnings by reviewing behavioral and neuroimaging
studies. In addition, poor singing resulting from a brain injury or neurogenetic
disorder (i.e., tone deafness or congenital amusia) is examined. Different lines
of evidence converge in indicating that poor singing is not a monolithic
deficit. A variety of poor-singing "phenotypes" are described,
with or without concurrent perceptual deficits. In addition, particular
attention is paid to the dissociations between specific abilities in poor
singers (e.g., production of absolute vs. relative pitch, pitch vs. time
accuracy). Such diversity of impairments in poor singers can be traced to
different faulty mechanisms within the vocal sensorimotor loop, such as pitch
perception and sensorimotor integration
Involvement of the Melanocortin-1 Receptor in Acute Pain and Pain of Inflammatory but Not Neuropathic Origin
Response to painful stimuli is susceptible to genetic variation. Numerous loci have been identified which contribute to this variation, one of which, MC1R, is better known as a gene involved in mammalian hair colour. MC1R is a G protein-coupled receptor expressed in melanocytes and elsewhere and mice lacking MC1R have yellow hair, whilst humans with variant MC1R protein have red hair. Previous work has found differences in acute pain perception, and response to analgesia in mice and humans with mutations or variants in MC1R.We have tested responses to noxious and non-noxious stimuli in mutant mice which lack MC1R, or which overexpress an endogenous antagonist of the receptor, as well as controls. We have also examined the response of these mice to inflammatory pain, assessing the hyperalgesia and allodynia associated with persistent inflammation, and their response to neuropathic pain. Finally we tested by a paired preference paradigm their aversion to oral administration of capsaicin, which activates the noxious heat receptor TRPV1. Female mice lacking MC1R showed increased tolerance to noxious heat and no alteration in their response to non-noxious mechanical stimuli. MC1R mutant females, and females overexpressing the endogenous MC1R antagonist, agouti signalling protein, had a reduced formalin-induced inflammatory pain response, and a delayed development of inflammation-induced hyperalgesia and allodynia. In addition they had a decreased aversion to capsaicin at moderate concentrations. Male mutant mice showed no difference from their respective controls. Mice of either sex did not show any effect of mutant genotype on neuropathic pain.We demonstrate a sex-specific role for MC1R in acute noxious thermal responses and pain of inflammatory origin
A simple 2 W continuous-wave laser system for trapping ultracold metastable helium atoms at the 319.8 nm magic wavelength
Platelet-rich plasma in orthopedic therapy: a comparative systematic review of clinical and experimental data in equine and human musculoskeletal lesions
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