36 research outputs found
Integrated genomic characterization of pancreatic ductal adenocarcinoma
Get PDFWe performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low neoplastic cellularity. Deep whole-exome sequencing revealed recurrent somatic mutations in KRAS, TP53, CDKN2A, SMAD4, RNF43, ARID1A, TGFβR2, GNAS, RREB1, and PBRM1. KRAS wild-type tumors harbored alterations in other oncogenic drivers, including GNAS, BRAF, CTNNB1, and additional RAS pathway genes. A subset of tumors harbored multiple KRAS mutations, with some showing evidence of biallelic mutations. Protein profiling identified a favorable prognosis subset with low epithelial-mesenchymal transition and high MTOR pathway scores. Associations of non-coding RNAs with tumor-specific mRNA subtypes were also identified. Our integrated multi-platform analysis reveals a complex molecular landscape of PDAC and provides a roadmap for precision medicine
Performance of Symydobius americanus (Homoptera: Aphididae) on paper birch grazed by caterpillars
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Movement and disappearance of mountain birch defoliators are influenced by the interactive effects of plant architecture and induced resistance
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Interspecific differences in movement and hunting success in damselfly larvae (Zygoptera: Insecta): responses to prey availability and predation threat
No full textDispersal of organisms in a patchy stream environment under different settlement scenarios
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Storage and depletion of lipid components in the pyloric caeca and ovaries of the seastarAsterias rubens during its annual reproductive cycle
No full textHAdV-2-suppressed growth of SV40 T antigen-transformed mouse mammary epithelial cell-induced tumours in SCID mice
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