Modeling the insect-vectors-mediated phytoplasm transmission in agroecosystems

Two models for the herbivore-insects-plants interactions are formulated, differing in the way the farmer’s behavior is accounted for. In the first one the farmer regularly checks the crop and possibly removes infected plants, reimplanting new healthy ones in their place. The second one instead considers a large crop where this behavior is not possible and where therefore the infection may propagate freely in it, via the action of insect vectors. Effector proteins are known to affect the insect-plant dynamics and their influence is here investigated. Although they cannot influence the ultimate ecosystem behavior, they do impact the speed at which the equilibria are attained, in some fortunate cases favoring a faster infection eradication

Persistence, adherence, healthcare resource utilization and costs for ocrelizumab in the real-world of the Campania Region of Italy

We aim to provide real-world evidence on the use of ocrelizumab for treating multiple sclerosis (MS), with specific regard to prescription pattern, adherence, persistence, healthcare resource utilization and related costs, also in relation to other disease-modifying treatments (DMTs)