2 research outputs found
Vascular related pregnancy complications: genetics and remote cardiovascular risk
Preeclampsia and intrauterine growth restriction (IUGR) are common vascular related pregnancy
syndromes of unknown cause. Both preeclampsia and IUGR are responsible for a significant
maternal and perinatal morbidity and mortality worldwide. Preeclampsia affects approximately
2.5-3.0% of women. It is diagnosed by de novo hypertension and proteinuria
after 20 weeks of gestation and potentially progresses to a multisystemic syndrome characterized
by increased vasoconstriction, metabolic changes, endothelial dysfunction, activation
of coagulation cascade and inflammatory response. Eclampsia is considered an end stage
of the syndrome characterized by generalized seizures. In addition to the maternal clinical
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Shared constitutional risks for maternal vascular-related pregnancy complications and future cardiovascular disease
Maternal predisposition to vascular and metabolic disease may underlie both vascular-related pregnancy complications, such as preeclampsia and intrauterine growth restriction, as well as future maternal cardiovascular disease. We aimed to substantiate this hypothesis with biochemical and anthropometric evidence by conducting an intergenerational case-control study in a Dutch isolated population including 106 women after preeclampsia or intrauterine growth restriction (median follow-up: 7.1 years) and their fathers (n=43) and mothers (n=64), as well as 106 control subjects after uncomplicated pregnancies with their fathers (n=51) and mothers (n=68). Cardiovascular risk profiles were assessed, including fasting glucose, lipids, anthropometrics, blood pressure, intima-media thickness, and metabolic syndrome. We found significantly higher fasting glucose levels, larger waist circumferences, and a 5-fold increased prevalence of hypertension in women with a history of preeclampsia as compared with control subjects (P<0.001). Likewise, their parents had higher glucose levels than control parents (P<0.05). Their mothers had larger waist circumferences and higher blood pressures (P<0.05). Also, women after pregnancies complicated by intrauterine growth restriction had higher glucose levels and increased prevalence of hypertension (P<0.01). Their fathers showed higher glucose levels as well (P<0.05). Mean carotid intima-media thickness was increased in a subset of women after preeclampsia diagnosed with chronic hypertension as compared with those without hypertension (P<0.01). Metabolic syndrome was more prevalent both in women with a history of preeclampsia and their mothers (P<0.05). We demonstrated intergenerational similarities in cardiovascular risk profiles between women after preeclampsia or intrauterine growth restriction and their parents. These findings suggest shared constitutional risks for vascular-related pregnancy complications and future cardiovascular disease