1,204 research outputs found
Weak solutions to problems involving inviscid fluids
We consider an abstract functional-differential equation derived from the
pressure-less Euler system with variable coefficients that includes several
systems of partial differential equations arising in the fluid mechanics. Using
the method of convex integration we show the existence of infinitely many weak
solutions for prescribed initial data and kinetic energy
Phage displayed peptides/antibodies recognizing growth factors and their tyrosine kinase receptors as tools for anti-cancer therapeutics.
The basic idea of displaying peptides on a phage, introduced by George P. Smith in 1985, was greatly developed and improved by McCafferty and colleagues at the MRC Laboratory of Molecular Biology and, later, by Barbas and colleagues at the Scripps Research Institute. Their approach was dedicated to building a system for the production of antibodies, similar to a naĂŻve B cell repertoire, in order to by-pass the standard hybridoma technology that requires animal immunization. Both groups merged the phage display technology with an antibody library to obtain a huge number of phage variants, each of them carrying a specific antibody ready to bind its target molecule, allowing, later on, rare phage (one in a million) to be isolated by affinity chromatography. Here, we will briefly review the basis of the technology and the therapeutic application of phage-derived bioactive molecules when addressed against key players in tumor development and progression: growth factors and their tyrosine kinase receptors
Monogenoidean parasites of fishes associated with coral reefs in the Ras Mohammed National Park, Egypt: preliminary results
AbstractA parasitological survey of the monogenoids of 14 species of common fishes associated with the local coral reefs of the Ras Mohammed National Park, National Parks of Egypt South Sinai Sector, Egypt, was carried out from May 2003 to May 2005. The monogenoids collected during the survey included 17 species: 8 previously described species, 7 new species in established genera, and 2 new species belonging to new genera
The scaling behaviour of screened polyelectrolytes
We present a field-theoretic renormalization group (RG) analysis of a single
flexible, screened polyelectrolyte chain (a Debye-H\"uckel chain) in a polar
solvent. We point out that the Debye-H\"uckel chain may be mapped onto a local
field theory which has the same fixed point as a generalised Potts
model. Systematic analysis of the field theory shows that the system is one
with two interplaying length-scales requiring the calculation of scaling
functions as well as exponents to fully describe its physical behaviour. To
illustrate this, we solve the RG equation and explicitly calculate the
exponents and the mean end-to-end length of the chain.Comment: 6 pages, 1 figure; changed title and slight modification to tex
Crossover from Isotropic to Directed Percolation
Percolation clusters are probably the simplest example for scale--invariant
structures which either are governed by isotropic scaling--laws
(``self--similarity'') or --- as in the case of directed percolation --- may
display anisotropic scaling behavior (``self--affinity''). Taking advantage of
the fact that both isotropic and directed bond percolation (with one preferred
direction) may be mapped onto corresponding variants of (Reggeon) field theory,
we discuss the crossover between self--similar and self--affine scaling. This
has been a long--standing and yet unsolved problem because it is accompanied by
different upper critical dimensions: for isotropic, and
for directed percolation, respectively. Using a generalized
subtraction scheme we show that this crossover may nevertheless be treated
consistently within the framework of renormalization group theory. We identify
the corresponding crossover exponent, and calculate effective exponents for
different length scales and the pair correlation function to one--loop order.
Thus we are able to predict at which characteristic anisotropy scale the
crossover should occur. The results are subject to direct tests by both
computer simulations and experiment. We emphasize the broad range of
applicability of the proposed method.Comment: 19 pages, written in RevTeX, 12 figures available upon request (from
[email protected] or [email protected]), EF/UCT--94/2, to be
published in Phys. Rev. E (May 1994
Strong Deformation Effects in Hot Rotating 46Ti
Exotic-deformation effects in 46Ti nucleus were investigated by analysing the
high-energy gamma-ray and the alpha-particle energy spectra. One of the
experiments was performed using the charged-particle multi-detector array ICARE
together with a large volume (4"x4") BGO detector. The study focused on
simultaneous measurement of light charged particles and gamma-rays in
coincidence with the evaporation residues. The experimental data show a
signature of very large deformations of the compound nucleus in the Jacobi
transition region at the highest spins. These results are compared to data from
previous experiments performed with the HECTOR array coupled to the EUROBALL
array, where it was found that the GDR strength function is highly fragmented,
strongly indicating a presence of nuclei with very large deformation.Comment: 10 pages, 6 figures, Proceedings of the Zakopane Conference on
Nuclear Physics, to be published in Acta Phys. Pol. B (2007
GDR Feeding of the Highly-Deformed Band in 42Ca
The gamma-ray spectra from the decay of the GDR in the compound nucleus
reaction 18O+28Si at bombarding energy of 105 MeV have been measured in an
experiment using the EUROBALL IV and HECTOR arrays. The obtained experimental
GDR strength function is highly fragmented, with a low energy (10 MeV)
component, indicating a presence of a large deformation and Coriolis effects.
In addition, the preferential feeding of the highly-deformed band in 42Ca by
this GDR low energy component is observed.Comment: 6 pages, 2 figures, Proceedings of the Zakopane2004 Symposium, to be
published in Acta Phys. Pol. B36 (2005
Two-way multi-lane traffic model for pedestrians in corridors
We extend the Aw-Rascle macroscopic model of car traffic into a two-way
multi-lane model of pedestrian traffic. Within this model, we propose a
technique for the handling of the congestion constraint, i.e. the fact that the
pedestrian density cannot exceed a maximal density corresponding to contact
between pedestrians. In a first step, we propose a singularly perturbed
pressure relation which models the fact that the pedestrian velocity is
considerably reduced, if not blocked, at congestion. In a second step, we carry
over the singular limit into the model and show that abrupt transitions between
compressible flow (in the uncongested regions) to incompressible flow (in
congested regions) occur. We also investigate the hyperbolicity of the two-way
models and show that they can lose their hyperbolicity in some cases. We study
a diffusive correction of these models and discuss the characteristic time and
length scales of the instability
Random Resistor-Diode Networks and the Crossover from Isotropic to Directed Percolation
By employing the methods of renormalized field theory we show that the
percolation behavior of random resistor-diode networks near the multicritical
line belongs to the universality class of isotropic percolation. We construct a
mesoscopic model from the general epidemic process by including a relevant
isotropy-breaking perturbation. We present a two-loop calculation of the
crossover exponent . Upon blending the -expansion result with
the exact value for one dimension by a rational approximation, we
obtain for two dimensions . This value is in agreement
with the recent simulations of a two-dimensional random diode network by Inui,
Kakuno, Tretyakov, Komatsu, and Kameoka, who found an order parameter exponent
different from those of isotropic and directed percolation.
Furthermore, we reconsider the theory of the full crossover from isotropic to
directed percolation by Frey, T\"{a}uber, and Schwabl and clear up some minor
shortcomings.Comment: 24 pages, 2 figure
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