Adsorption of Carbon Dioxide on Activated Carbon Derived from Asphaltene & Palm Kernel Shell Mixture

Carbon dioxide (CO2) has been considered as the major influence to the rise of the temperature globally. Activated carbon is used as the adsorbent for CO2 capture due to their wide obtainability, high thermal permanence, unresponsive to moisture, large surface areas and distinctive porosities leading to high adsorption capacities. The aim of the project is to study the adsorption of CO2 in activated carbon derived from asphaltene and palm kernel shell (PKS) by mixing both precursors. Activated carbon is synthesized from the individual precursors as well as mixed precursors of asphaltene and PKS at different ratio (1:1, 1: 2.5, 1: 5.0 and 1: 7.5) through chemical activation utilizing potassium hydroxide (KOH) as the activating agent at 600℃ and 60 min

SUPERCRITICAL EXTRACTION OF CARYOPHYLLENE FROM MELALEUCA CAJUPUTI LEAVES AS PADDY HERBICIDES ALLELOPATHY: OPTIMIZATION, MODELLING AND EFFICACY TEST

In light of rice production problem and food security, control of paddy weeds with incorporation of allelopathy compounds served as new alternative for sustainable weeds management. In current studies, the oil from Melaleuca cajuputi was extracted and analyzed for its possible allelopathy compound present. Central composite design (CCD) was used to optimize the oil yield of Melaleuca cajuputi leaves using supercritical carbon dioxide (SC-CO2) extraction

SUPERCRITICAL EXTRACTION OF CARYOPHYLLENE FROM MELALEUCA CAJUPUTI LEAVES AS PADDY HERBICIDES ALLELOPATHY: OPTIMIZATION, MODELLING AND EFFICACY TEST

In light of rice production problem and food security, control of paddy weeds with incorporation of allelopathy compounds served as new alternative for sustainable weeds management. In current studies, the oil from Melaleuca cajuputi was extracted and analyzed for its possible allelopathy compound present. Central composite design (CCD) was used to optimize the oil yield of Melaleuca cajuputi leaves using supercritical carbon dioxide (SC-CO2) extraction

Human-centered service design and transformative innovation: Beginning to understand how innovation culture shifts within the public health system in Western Australia

The cultivation of innovation culture in any public healthcare system is complex, requiring a thorough understanding and reframing of evolving transformation at every level. While human-centered service design is important, the organizational culture and systems that create a foundation for service delivery require specific research. It is especially important to understand the foundations for the development of strategies that enable system-wide culture transformation. This chapter provides a comprehensive mapping of the innovation initiatives and leadership across the public healthcare system in Western Australia. In-depth design-led conversations were held with stakeholders, healthcare leaders, and innovators, at all stages of their innovation development, to map system complexity and explore factors that could contribute to the development of transformative innovation

Phosphoproteomics of three exercise modalities identifies canonical signaling and C180RF25 as an AMPK substrate regulating skeletal muscle function

Exercise induces signaling networks to improve muscle function and confer health benefits. To identify divergent and common signaling networks during and after different exercise modalities, we performed a phosphoproteomic analysis of human skeletal muscle from a cross-over intervention of endurance, sprint, and resistance exercise. This identified 5,486 phosphosites regulated during or after at least one type of exercise modality and only 420 core phosphosites common to all exercise. One of these core phosphosites was S67 on the uncharacterized protein C18ORF25, which we validated as an AMPK substrate. Mice lacking C18ORF25 have reduced skeletal muscle fiber size, exercise capacity, and muscle contractile function, and this was associated with reduced phosphorylation of contractile and Ca2+ handling proteins. Expression of C18ORF25 S66/67D phospho-mimetic reversed the decreased muscle force production. This work defines the divergent and canonical exercise phosphoproteome across different modalities and identifies C18ORF25 as a regulator of exercise signaling and muscle function

The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation

Immune-modulating therapies have revolutionized the treatment of chronic diseases, particularly cancer. However, their success is restricted and there is a need to identify new therapeutic targets. Here, we show that natural killer cell granule protein 7 (NKG7) is a regulator of lymphocyte granule exocytosis and downstream inflammation in a broad range of diseases. NKG7 expressed by CD4+\ua0and CD8+\ua0T cells played key roles in promoting inflammation during visceral leishmaniasis and malaria—two important parasitic diseases. Additionally, NKG7 expressed by natural killer cells was critical for controlling cancer initiation, growth and metastasis. NKG7 function in natural killer and CD8+\ua0T cells was linked with their ability to regulate the translocation of CD107a to the cell surface and kill cellular targets, while NKG7 also had a major impact on CD4+\ua0T cell activation following infection. Thus, we report a novel therapeutic target expressed on a range of immune cells with functions in different immune responses

The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation

Immune-modulating therapies have revolutionized the treatment of chronic diseases, particularly cancer. However, their success is restricted and there is a need to identify new therapeutic targets. Here, we show that natural killer cell granule protein 7 (NKG7) is a regulator of lymphocyte granule exocytosis and downstream inflammation in a broad range of diseases. NKG7 expressed by CD4+ and CD8+ T cells played key roles in promoting inflammation during visceral leishmaniasis and malaria—two important parasitic diseases. Additionally, NKG7 expressed by natural killer cells was critical for controlling cancer initiation, growth and metastasis. NKG7 function in natural killer and CD8+ T cells was linked with their ability to regulate the translocation of CD107a to the cell surface and kill cellular targets, while NKG7 also had a major impact on CD4+ T cell activation following infection. Thus, we report a novel therapeutic target expressed on a range of immune cells with functions in different immune responses