Rate Ratios (RRs) for cancers analysed for British White & British Indian children in Leicester.

<p>Rate Ratios (RRs) for cancers analysed for British White & British Indian children in Leicester.</p

Number of cases , age standardised (per 100 000) cancer incidence rates and number of person-years of observation for White & Indian children in Leicester, and for children in Mumbai & Ahmedabad, India. (All rates are standardised to the age distribution of the Segi standard population).

<p>Number of cases , age standardised (per 100 000) cancer incidence rates and number of person-years of observation for White & Indian children in Leicester, and for children in Mumbai & Ahmedabad, India. (All rates are standardised to the age distribution of the Segi standard population).</p

Binding of phages to bacterial hosts and the subsequent release of phage at lysis of infected cells.

<p>The plot shows data from one of the three cultures in the binding assay, with observed concentrations of free phages in log₁₀ PFU mL⁻¹ (points) and the fitted curve <i>V</i>(<i>t</i>) (line), derived from Equation 1. Lysis of infected hosts is well synchronised at approximately 1.3 hours, although this is exaggerated by the fitted curve. The phage concentration does not appear to increase, which is consistent with the low estimate for the burst size (approximately equal to 2 virions).</p

Phage decay in the culture medium in the absence of hosts.

<p>The plot shows data from one of the three cultures in the phage decay experiment, with observed concentrations in log₁₀ PFU mL⁻¹ (points) and the fitted curve log₁₀<i>V</i>(<i>t</i>) = log₁₀<i>V</i>₀−<i>mt</i> (line). The phage concentration declines linearly on log-linear axes, indicating approximately exponential decay with estimated rate 1.062×10⁻² h⁻¹.</p

Definitions of model parameters for Equation 1.

<p>Fitted values for these parameters are given in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000253#ppat-1000253-t002" target="_blank">Table 2</a> and <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000253#ppat-1000253-t003" target="_blank">Table 3</a>.</p

Model parameters from Equation 1 where parameters are allowed to vary between cultures, fitted to data from the interaction experiments.

<p>Estimates were obtained by maximum likelihood as described in the text; parameter notation is as in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000253#ppat-1000253-t001" target="_blank">Table 1</a>. The total AIC for this model is 4948.075. There is a strong positive relationship between the logarithm of the initial phage concentration and the logarithms of the inundation threshold <i>V_I</i> and proliferation threshold <i>S_P</i>, which together indicate dose-dependence of the binding rate <i>b</i>.</p

Model parameters from Equation 1 where parameters are common to all cultures, fitted to data from the interaction experiments.

<p>Estimates were obtained by maximum likelihood as described in the text; parameter notation is as in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000253#ppat-1000253-t001" target="_blank">Table 1</a>. The total AIC for this model is 5765.540.</p

Data from interaction experiments together with fitted curves obtained by maximum likelihood estimation.

<p>Concentrations of <i>C. jejuni</i> (circles; black) and phage (triangles; red) vary together in a way consistent with the threshold theory of phage-bacterial interactions. Fitted models in which parameters are either common to all (dashed) or allowed to vary between cultures (solid). Panels (A–H) correspond to cultures 1–8, respectively, with fitted parameters as given in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000253#ppat-1000253-t002" target="_blank">Table 2</a> and <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000253#ppat-1000253-t003" target="_blank">Table 3</a>.</p