RAFT polymerization of dimethyl(methacryloyloxy)- methyl phosphonate and its phosphonic acid derivative: a new opportunity for phosphorus-based materials

International audienceThe RAFT polymerization of dimethyl(methacryloyloxy)methyl phosphonate (MAPC1) using dithioester chain transfer agents is reported for the first time to our knowledge in the literature. Poly(dimethyl(methacryloyloxy)methyl phosphonate) (PMAPC1) was synthesized in DMF at 70 C with a good control over the molecular weight, the latter ranging from 8000 to 24 000 g mol 1. Polymers were characterized by 1H and 31P NMR, and size exclusion chromatography using both refractive index and triple detection. The effect of the solvent was also investigated. We demonstrated that polarity had an effect on the control of the polymerization as low polarity led to low polymerization rate and termination reactions whereas very high polarity resulted in high polymerization rate but also transfer reactions. Additionally, we showed that it was possible to restart the RAFT polymerization from a PMAPC1 macrochain transfer agent. PMAPC1 was hydrolyzed to afford poly((methacryloyloxy)methyl phosphonic acid) (hPMAPC1), whose pKa values were determined. Finally, we achieved the controlled RAFT polymerization of the (methacryloyloxy)methyl phosphonic acid (hMAPC1). The easy obtaining of PMAPC1 and hPMAPC1 opens the way to the synthesis of complex polymer architectures

Phosphorus-Containing Polymers: A Great Opportunity for the Biomedical Field

International audienceThis Review is focused on the growing interest brought to phosphorus-containing organic materials for applications in the biomedical field, mainly because of their properties such as biocompatibility, hemocompatibility, and protein adsorption resistance. It mainly describes relevant works achieved on these materials for various applications: dentistry, regenerative medicine, and drug delivery. Special attention was given to 2-methacryloyloxyethyl phosphorylcholine (MPC) monomer as the latter appeared of great importance because of its biomimetic structure due to the presence of the phospholipid group on its structure. As a result, much research effort is currently concentrated on the development of phosphorylcholine- containing (co)polymers that represent a promising class of materials

Polymerization of Phosphorus-Containing (Meth)acrylate Monomers

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