Role of surface states in the Casimir force between semiconducting films

We present results of first principle calculations of the Casimir force between Si films of nanometric size, which show that it depends significantly upon the configuration of the surface atoms, and give evidence of the importance of surface states.Comment: to be published on J.Phys.

Experimental Analysis of Optimal Operation Mode of a Ground Source Heat Pump System

Abstract This paper presents experimental data and modeling of a ground source heat pump (GSHP) with variable speed compressor, variable speed water pumps and variable speed fans in the coils, installed at Hiref Spa (Italy) in the framework of the European Project Ground-Med. The present model has been developed to evaluate the operating conditions that lead to the maximum seasonal coefficient of performance and to analyze the behavior of the system at partial loads since variable capacity heat pumps do not work at nominal power for most of the time. The control parameters of the model that can be varied are the followings: frequency of compressor, frequency of water pump to the borehole heat exchangers, frequency of water pump to the user, velocity of the fans and water temperature to the user. The model has been compared with experimental data taken during a heating season and it can be the baseline to develop a control strategy with the final objective of maximizing the seasonal coefficient of performance of the system

Modeling Radiotherapy Induced Normal Tissue Complications: An Overview beyond Phenomenological Models

An overview of radiotherapy (RT) induced normal tissue complication probability (NTCP) models is presented. NTCP models based on empirical and mechanistic approaches that describe a specific radiation induced late effect proposed over time for conventional RT are reviewed with particular emphasis on their basic assumptions and related mathematical translation and their weak and strong points

The importance of spatial adjustment processes in the labour force: the case of Albania

Using census data on work commuting in Albania – collected for the first time in 2011 – this study examines the spatial adjustment processes between demand and supply of labour across the country. The first part focuses on the spatial adjustment of labour forces that occur within and between Albanian’s prefectures. Several statistical indicators, derived using origin-destination matrices, measure the differential levels of attraction and expulsion of each prefecture. Results show a high level of heterogeneity and emphasise the crucial role of spatial contiguity among prefectures on this spatial dynamic. The second part examines the role of the municipality of Tirana. This is first investigated within a three-territorial-units system (the municipality of Tirana, rest of the prefecture and rest of Albania) and then within the prefecture as a closed system. Interestingly, 71.5% of all the commuting flows directed to the Municipality originate from municipalities located very close to Tirana (less than 10 km). We conclude that the spatial structure of the prefecture, reasonably extendable to the whole country, can be defined as monocentric. Further studies should focus on the implied costs of this system to the society and environment of Albania

The importance of spatial adjustment processes in the labour force: the case of Albania

Using census data on work commuting in Albania – collected for the first time in 2011 – this study examines the spatial adjustment processes between demand and supply of labour across the country. The first part focuses on the spatial adjustment of labour forces that occur within and between Albanian’s prefectures. Several statistical indicators, derived using origin-destination matrices, measure the differential levels of attraction and expulsion of each prefecture. Results show a high level of heterogeneity and emphasise the crucial role of spatial contiguity among prefectures on this spatial dynamic. The second part examines the role of the municipality of Tirana. This is first investigated within a three-territorial-units system (the municipality of Tirana, rest of the prefecture and rest of Albania) and then within the prefecture as a closed system. Interestingly, 71.5% of all the commuting flows directed to the Municipality originate from municipalities located very close to Tirana (less than 10 km). We conclude that the spatial structure of the prefecture, reasonably extendable to the whole country, can be defined as monocentric. Further studies should focus on the implied costs of this system to the society and environment of Albania

The importance of spatial adjustment processes in the labour force: the case of Albania

Using census data on work commuting in Albania – collected for the first time in 2011 – this study examines the spatial adjustment processes between demand and supply of labour across the country. The first part focuses on the spatial adjustment of labour forces that occur within and between Albanian’s prefectures. Several statistical indicators, derived using origin-destination matrices, measure the differential levels of attraction and expulsion of each prefecture. Results show a high level of heterogeneity and emphasise the crucial role of spatial contiguity among prefectures on this spatial dynamic. The second part examines the role of the municipality of Tirana. This is first investigated within a three-territorial-units system (the municipality of Tirana, rest of the prefecture and rest of Albania) and then within the prefecture as a closed system. Interestingly, 71.5% of all the commuting flows directed to the Municipality originate from municipalities located very close to Tirana (less than 10 km). We conclude that the spatial structure of the prefecture, reasonably extendable to the whole country, can be defined as monocentric. Further studies should focus on the implied costs of this system to the society and environment of Albania

Comparison of methods to determine accurate dose calibrator activity measurements

<p>Abstract</p> <p>Background</p> <p>In nuclear medicine, liquid radiopharmaceuticals for diagnostic or therapeutic purposes are administered to patients by using various types of syringes with different volumes. The activity of each "dose" must be carefully measured and documented prior to administration using an activity calibrator.</p> <p>Methods</p> <p>Calibrator response is a function of the measurement geometry and, in particular, it depends on the syringe type and filling volume. To minimize the uncertainty associated with the measured activity of the syringe, it is necessary to calculate a calibration curve depending on filling volume for each syringe type. This curve can be obtained by fitting experimentally determined volume correction factors.</p> <p>Results</p> <p>A theoretical evaluation of volume correction factors for syringes is reported for three different experimental methods. The aim is to determine the most accurate experimental method among those considered, by examining the expression of uncertainty for the correction factor. This theoretical analysis was then tested experimentally.</p> <p>Conclusion</p> <p>The agreement between the experimental data obtained in the constant activity method and gravimetric method at constant specific activity and the small associated uncertainties show the accuracy of these two procedures; while the volumetric method at constant specific activity could lead to a wrong evaluation of the correction factors.</p

Prognostic and predictive role of CXCR4, IGF-1R and Ezrin expression in localized synovial sarcoma: is chemotaxis important to tumor response?

BACKGROUND: Synovial sarcoma (SS) is a rare tumor, with dismal survival when metastatic. The role of adjuvant chemotherapy is debated. New prognostic and predictive factors are needed. METHODS: We reviewed patients with localized SS; SS18-SSX fusion transcript presence was confirmed by FISH and RT-PCR. Expression of CXCR4, IGF-1R and Ezrin were evaluated by immunohistochemistry. RESULTS: Tumor samples from 88 SS patients (45 female; 43 male) with median age 37 years (range 11-63) were selected. The size of the lesion was\u2009&gt;\u20095 cm in 68% of patients and 34% of cases presented biphasic histotype. All patients underwent surgery, 56% adjuvant radiotherapy (RT), 65% adjuvant chemotherapy. A positive stain for IGF-1R was detected in 55 patients, with nucleus expression in 21 patients. CXCR4 was expressed in 74 patients, nuclear pattern in 31 patients. 80 SS were positive to Ezrin, 48 had cytoplasmatic location, 32 membrane location. With a median follow-up of 6 years (1-30 years), the 5-year overall survival (OS) was 70% (95% CI 60-81). 5-year OS was 63% (95% CI 41-85%) for patients with positive IGF-1R/nuclear expression, and 73% (95% CI 61-85%; P\u2009=\u20090.05) in negative patients. 5-year OS was 47% (95% CI 27-66%) in patients with positive CXCR4/nuclear staining, and 86% (95% CI 76-96%, P = 0.0003) in negative cases. No survival difference was found according to Ezrin expression. By multivariate analysis, nuclear expression of CXCR4 and IGF-1R was confirmed independent adverse prognostic factor for SS patient survival linked to the use of chemotherapy. CONCLUSIONS: Our findings have important potential implications demonstrating that together with clinical prognostic factors such as radiotherapy and age, CXCR4 and IGF-1R negatively influences survival in patients with localized SS. We believe that further studies addressed to the effects of CXCR4 and IGF-1R inhibitors on cell viability and function are needed to plan new and more appropriate SS treatments

Ostracoda of the Italian ricefields thirty years on: new synthesis and hypothesis

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Quick assessment of cell-free DNA in seminal fluid and fragment size for early non-invasive prostate cancer diagnosis

Liquid biopsy consists in the quantification and qualification of circulating cell-free DNA (cfDNA) and tumor-derived DNA (ctDNA) for cancer recognition. Recently, the characterization of seminal cfDNA (scfDNA) has been reported as a possible biomarker for prostate cancer (PCa) diagnosis