In situ characterization of pin diode waveforms using electro‐optic sampling

In situ measurements of nonlinear waveforms produced by a PIN diode under large‐signal excitation have been performed using ultrafast electro‐optic (EO) sampling.The waveforms were sampled using an EO probe positioned immediately after the diode. These data validate a nonlinear model and improve representation of the waveform across the circuit. © 2012 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:2653–2656, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.27119Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/93525/1/27119_ftp.pd

Vanadyl sulfate inhibits NO production via threonine phosphorylation of eNOS.

Exposure to excessive vanadium occurs in some occupations and with consumption of some dietary regimens for weight reduction and body building. Because vanadium is vasoactive, individuals exposed to excessive vanadium may develop adverse vascular effects. We have previously shown that vanadyl sulfate causes acute pulmonary vasoconstriction, which could be attributed in part to inhibition of nitric oxide production. In the present study we investigated whether NO inhibition was related to phosphorylation of endothelial nitric oxide synthase (eNOS). VOSO4 produced dose-dependent constriction of pulmonary arteries in isolated perfused lungs and pulmonary arterial rings and a right shift of the acetylcholine-dependent vasorelaxation curve. VOSO4 inhibited constitutive as well as A23187-stimulated NO production. Constitutive NO inhibition was accompanied by increased Thr495 (threonine at codon 495) phosphorylation of eNOS, which would inhibit eNOS activity. Thr495 phosphorylation of eNOS and inhibition of NO were partially reversed by pretreatment with calphostin C, a protein kinase C (PKC) inhibitor. There were no changes in Ser1177 (serine at codon 1177) or tyrosine phosphorylation of eNOS. These results indicate that VOSO4 induced acute pulmonary vasoconstriction that was mediated in part by the inhibition of endothelial NO production via PKC-dependent phosphorylation of Thr495 of eNOS. Exposure to excessive vanadium may contribute to pulmonary vascular diseases

IBD in the Times of COVID-19

We discuss the impact that COVID-19 has had on the care of patients with inflammatory bowel disease and the use of telemedicine after the pandemic resolves

Database S1 for triaxial and nanoindentation data on Vaca Muerta shale

This is data relating to triaxial and nanoindentation measurement Data on Vaca Muerta shale for: Mighani, S. et al. “Creep Deformation in Vaca Muerta Shale from Nanoindentation to Triaxial Experiments