Diagnostic de l’industrie automobile au Maroc : Analyse SWOT

Le secteur de l’industrie automobile au Maroc se positionne désormais au 1er rang des producteurs de voitures de tourisme en Afrique et à la 24ème place au niveau mondial. Il a tracé  au fil des années, son chemin pour se positionner, aujourd’hui, au sommet ayant fait de lui une base mondiale de production automobile.Pour mieux comprendre la position de l’industrie automobile marocaine, cet article essaiera d’identifier, à travers une analyse SWOT, les forces qui contribuent à son développement, les faiblesses à surmonter, les opportunités qui s’ouvrent à ce secteur et les menaces qui pèsent sur son développement

ETV6-RUNX1 Rearrangement in Tunisian Pediatric B-Lineage Acute Lymphoblastic Leukemia

In this study, Forty-one out of fifty-seven Tunisian children with B-lineage acute lymphoblastic leukemia (B-ALL), and without cytogenetically detectable recurrent abnormalities at the time of the diagnosis, were evaluated by fluorescence in situ hybridization (FISH) for the t(12;21). This translocation leads ETV6-RUNX1 (previously TEL-AML1) fusion gene. 16 patients (28%) had ETV6-RUNX1 rearrangement. In addition to this rearrangement, two cases showed a loss of the normal ETV6 allele, and three others showed an extra signal of the RUNX1 gene. Seven patients without ETV6-RUNX1 rearrangement showed extra signals of the RUNX1 gene. One out of the 7 patients was also associated with a t(3;12) identified by FISH. This is the first Tunisian study in which we report the incidence of t(12;21) among childhood B-lineage ALL and in which we have found multiple copies of RUNX1. Finally, our findings confirm that additional or secondary genetic changes are commonly encountered in pediatric B-lineage ALL with ETV6-RUNX1 gene fusion which is envisaged to play a pivotal role in disease progression

Zinc oxide nanoparticles in meat packaging: A systematic review of recent literature

Questions have been raised apropos food spoilage, which may pose a great hazard to the global environment and human health. Amongst bio-safe material that retains photocatalysis and impacts, photo-oxidizing on biological and species chemical are ZnO nanoparticles (ZnO-NPs). In this respect, this current paper covers a wide range of topics, starting from the ZnO-NPs synthesis and antibacterial potential to their functional application in meat packaging. A deep comparison of the physicochemical properties of ZnO-NPs synthesized through different routers was reported. In addition, a special focus has been given to antibacterial mechanisms that underlie synthesis parameters. This review also examined the ZnO-NPs impact on the chemico–physico–mechanical properties of the functional coatings/films features. Likewise, the employment of ZnO-NPs in meat packaging was also evaluated. As safer nanoparticles, ZnO-NPs enhance stored meat product quality by microflora growth limitation and retards lipid/protein oxidation. Remarkably, active packaging comprising ZnO-NPs, synthesized or not by plants, showed an eco-friendly solution and future alternative in the meat industry. Information about these topics could help students and scientific researchers who are engaged in chemical engineering, chemistry and meat technology communities to approach the complex thematic of ZnO-NPs.CYTED | Ref.119RT0568GAIN (Axencia Galega de Innovación) | Ref. IN607A2019/01Universidade de Vigo/CISUG

Molecular and Structural Characterizations of Lipases from Chlorella by Functional Genomics

Microalgae have been poorly investigated for new-lipolytic enzymes of biotechnological interest. In silico study combining analysis of sequences homologies and bioinformatic tools allowed the identification and preliminary characterization of 14 putative lipases expressed by Chlorella vulagaris. These proteins have different molecular weights, subcellular localizations, low instability index range and at least 40% of sequence identity with other microalgal lipases. Sequence comparison indicated that the catalytic triad corresponded to residues Ser, Asp and His, with the nucleophilic residue Ser positioned within the consensus GXSXG pentapeptide. 3D models were generated using different approaches and templates and demonstrated that these putative enzymes share a similar core with common α/β hydrolases fold belonging to family 3 lipases and class GX. Six lipases were predicted to have a transmembrane domain and a lysosomal acid lipase was identified. A similar mammalian enzyme plays an important role in breaking down cholesteryl esters and triglycerides and its deficiency causes serious digestive problems in human. More structural insight would provide important information on the enzyme characteristics

Etude de techniques de contrôle des activités d’un processeur pour en limiter les variations en température

Encadré par Michel Auguin et Maher BEN JEMAAThe electronic circuits in recent technology have a reliability which begins to decline because of their greater sensitivity to certain physical constraints such as the temperature of the junctions or the changes of this temperature. To avoid this degradation of reliability, it is necessary to control both the maximum temperature of the component and thesuccessive amplitudes of temperature undergone by the component (thermal cycles).To define such control, it is necessary to identify the important blocks of the circuit and tomodel it in terms of power dissipation.Les circuits électroniques en technologie récente ont une fiabilité qui commence à décroitre du fait de leur sensibilité importante à certaines contraintes physiques comme la température des jonctions ou aux variations de cette température. Pour éviter cette dégradation de fiabilité, il est nécessaire de contrôler à la fois la température maximum du composant et les amplitudes successives de température subies par le composant (cycles thermiques).Pour définir un tel contrôle il est nécessaire d’identifier les blocs importants du circuit et de lecaractériser et modéliser en termes de puissance dissipé

Mycotoxins Analysis in Cereals and Related Foodstuffs by Liquid Chromatography-Tandem Mass Spectrometry Techniques

In the entire world, cereals and related foodstuffs are used as an important source of energy, minerals, and vitamins. Nevertheless, their contamination with mycotoxins kept special attention due to harmful effects on human health. The present paper was conducted to evaluate published studies regarding the identification and characterization of mycotoxins in cereals and related foodstuffs by liquid chromatography coupled to (tandem) mass spectrometry (LC-MS/MS) techniques. For sample preparation, published studies based on the development of extraction and clean-up strategies including solid-phase extraction, solid-liquid extraction, and immunoaffinity columns, as well as on methods based on minimum clean-up (quick, easy, cheap, effective, rugged, and safe (QuEChERS)) technology, are examined. LC-MS/MS has become the golden method for the simultaneous multimycotoxin analysis, with different sample preparation approaches, due to the range of different physicochemical properties of these toxic products. Therefore, this new strategy can be an alternative for fast, simple, and accurate determination of multiclass mycotoxins in complex cereal samples

Development and stability studies of sunscreen cream formulations containing three photo-protective filters

The present study aimed to formulate and subsequently evaluate sunscreen cream (W/O/W emulsion) containing three photo-protective filters: benzophenone-3, ethylhexyl methoxycinnamate and titanium dioxide at different percentages. Formulations were stored at 8, 25 and 40 °C for four weeks to investigate their stability. Color, centrifugation, liquefaction, phase separation, pH and Sun Protection Factor (SPF) of sunscreen cream formulations were determined. The microbiological stability of the creams was also evaluated and the organoleptic quality was carried out for 28 days. Interestingly, the combination of 7% Benzophenone-3, 7% Ethylhexyl methoxycinnamate and 6% Titanium dioxide preserved physicochemical properties of the product and was efficient against the development of different spoilage microorganisms as well as aerobic plate counts, Pseudomonas aeruginosa, Staphylococcus aureus, and yeast and mold counts. Furthermore, a good stability was observed for all formulations throughout the experimental period. The newly formulated sunscreen cream was proved to exhibit a number of promising properties and attributes that might open new opportunities for the development of more efficient, safe, and cost-effective skin-care, cosmetic, and pharmaceutical products

Engineered glucose isomerase from Streptomyces sp. SK is resistant to Ca2+ inhibition and Co2+ independent

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