QT dispersion as an attribute of T-loop morphology

BACKGROUND: The suggestion that increased QT dispersion (QTD) is due to increased differences in local action potential durations within the myocardium is wanting. An alternative explanation was sought by relating QTD to vectorcardiographic T-loop morphology. METHODS AND RESULTS: The T loop is characterized by its amplitude and width (defined as the spatial angle between the mean vectors of the first and second halves of the loop). We reasoned that small, wide ("pathological") T loops produce larger QTD than large, narrow ("normal") loops. To quantify the relationship between QTD and T-loop morphology, we used a program for automated analysis of ECGs and a database of 1220 standard simultaneous 12-lead ECGs. For each ECG, QT durations, QTD, and T-loop parameters were computed. T-loop amplitude and width were dichotomized, with 250 microV (small versus large amplitudes) and 30 degrees (narrow versus wide loops) taken as thresholds. Over all 1220 ECGs, QTDs were smallest for large, narrow T loops (54.2+/-27.1 ms) and largest for small, wide loops (69. 5+/-33.5 ms; P<0.001). CONCLUSIONS: QTD is an attribute of T-loop morphology, as expressed by T-loop amplitude and width

Mid-frequency aperture arrays: the future of radio astronomy

Aperture array (AA) technology is at the forefront of new developments and discoveries in radio astronomy. Currently LOFAR is successfully demonstrating the capabilities of dense and sparse AA's at low frequencies. For the mid-frequencies, from 450 to 1450MHz, AA's still have to prove their scientific value with respect to the existing dish technology. Their large field-of-view and high flexibility puts them in an excellent position to do so. The Aperture Array Verification Program is dedicated to demonstrate the feasibility of AA's for science in general and SKA in particular. For the mid-frequency range this has lead to the development of EMBRACE, which has already demonstrated the enormous flexibility of AA systems by observing HI and a pulsar simultaneously. It also serves as a testbed to demonstrate the technological reliability and stability of AA's. The next step will put AA technology at a level where it can be used for cutting-edge science. In this paper we discuss the developments to move AA technology from an engineering activity to a fully science capable instrument. We present current results from EMBRACE, ongoing tests of the system, and plans for EMMA, the next step in mid-frequency AA technology.Comment: 8 pages, 7 figures, proceedings of Resolving The Sky - Radio Astronomy: Past, Present and Future (RTS2012), April 17-20, 2012, Manchester, U