Analysts: “Consultants” or “Independent Policy Actors”

The author points out empirical indicators to distinguish “consultants” from analysts as “independent policy actors”. The complexity of decision-making processes in modern states created demand for independent expert support. This demand has been satisfied by new institutes of intellectual political support – think tanks. Support, an estimation of political decisions and alternatives, generating of ideas, education and elite formation became their functions. According to the functional approach, due to the complexity and scale of modern administrative problems, the expert became an integral part of the decision-making process. In differentiated social systems, in order to increase the efficiency of decisions and to maintain the social “feedback” mechanism, policy-makers involve experts, including think tanks, to work out new and to estimate old political decisions. In these processes think tanks are engaged, conducting researches and consultations for the decision-makers. So in modern states the mechanism of “feedback” is carried out. In practice, we can see some analysts and experts who pretend to play a dominant role in policy; some who legitimize policy of the government, decisions of a political leader or a current political regime; some who conduct professional research and development of the “feedback mechanism” within a policy cycle; and some who have real power on minds of the elites and/or citizens. The author aims to figure out the factors that influence the changing political status of the analysts, what makes them independent political actors, and in what conditions they come to serve the elites’ interest. And, most importantly, how we can fix or stabilize the analysts’ status as independent and powerful political actors even in an unfavorable political climate

PEDAGOGICAL CONDITIONS OF ECONOMIC EDUCATION OF CHILDREN IN PRESCHOOL EDUCATIONAL INSTITUTION

The urgency of the problem under investigation due to the fact that under the conditions of modern society cannot do without a thorough economic education of the younger generation. Article aims to identify and study of pedagogical conditions of economic education of children in preschool educational institution, including the organization and saturation types of children's activity information on the economic life of the family, people, society and development on this basis of cognitive interest to the positive norms and values of social and economic society; interaction of preschool educational institution and the family in the development of economic education began in children. The leading method to the study of this problem was the pedagogical experiment (notes forming, control); allowing to identify the levels of economic education. Article Submissions may be useful to teachers of preschool educational institutions in the disclosure to the child diverse world economy, as well a

Research on the Effectiveness of Students’ Communicative Competence Formation

The formation of communicative competence among university students is becoming especially relevant in the uncertain and changeable world. In the study, competencies of a general nature are called invariant by the theory of the structure of the content of education, developed by Academician V. S. Lednev. The paper focuses on the effectiveness of the formation of students’ invariant communicative competence in a nontraditional form of education - joint training of Russian and international students. The results of the study show that co-education of Russian and foreign students contributes to the development of their invariant communicative competencies better than traditional education. The novelty of the research is the formation of students’ invariant communicative competence occurs in conditions different from traditional teaching. Namely, it occurs in the process of joint training of Russian students with foreign citizens. Research materials can be used in the work of higher educational institutions

ANTIOXIDANT, METABOLIC AND ANTITUMOR ACTIVITY OF TRITERPENOIDS COMBINATION WITH CYTOSTATICS

Objective: To study the effect of betulin derivatives combination with 5-fluorouracil or hydrazine sulfate on the ROS generation, the SOD and LDH activity using rat blood, as well as the effect of combination drugs on Ehrlich carcinoma in experiments on mice. Methods: We used a chemiluminescence technique to study the ROS generation, and spectrophotometry to determine the MDA level and the SOD and LDH activity. The model of transplanted Ehrlich ascites carcinoma was investigated on mice using a cytological analysis of ascitic fluid cells according to Pappenheim`s method. Results: In vitro experiments on rat blood at the doses of 2, 5 and 10 μg per ml revealed the dose-dependent effect of combination drugs on the antioxidant properties. In plasma, the ROS generation and the MDA level increased by 10-300% in comparison with control at the doses of 5 and 10 μg per ml only. Still, the SOD and LDH activity in general increased by 10-130% in comparison with control under the action of the studied combination drugs. The study on mice showed the effectiveness of a combination of triterpenoids and cytostatics in Ehrlich ascites carcinoma therapy. The state and behavior of the animals improved, the volume of ascites fluid decreased by 40-50% after treatment for 10 d. Conclusion: The combination of betulin derivatives with cytostatics can be used as antitumor drugs in Ehrlich ascites carcinoma therapy that is due to metabolic plasticity, increased ROS generation in enhanced antioxidant enzyme protection

THE IMPROVEMENT OF BETULIN-3, 28-DIPHOSPHATE WATER-SOLUBILITY BY COMPLEXATION WITH AMINES–MEGLUMINE AND XYMEDON

Objective: To study betulin-3,28-diphosphate (BDP) water solubility improved by forming salt complexes with hydrophilic amino alcohols: meglumine as acidosis corrector and xymedon as the water-soluble antioxidant. Methods: We used 13C-, 31P-NMR, UV-spectroscopy and potentiometric titration to study the BDP-amine salt complexes formation and their solubility using HPLC-analysis. Results: The participation of xymedon in the proton transfer reaction with BDP in aqueous solutions was confirmed by the bathochromic shift of the carbonyl band from 299.1 nm to 304.2 nm, and by a hyperchromic effect (molar extinction ε from 8508 to 10 441 l·mol-1·cm-1) in UV-spectra. BDP complexation with meglumine was estimated by UV-spectral molar ratio method at 256 nm. Molar ratio of BDP-amine complexes (1:4) was proved by 31P-NMR. The chemical shift of phosphorus at C-3 atom of BDP (δ =-0.58 ppm) changed to+3.39 ppm, and at C-28 atom (δ =+0.28 ppm)–to+4.60 ppm. BDP solubility increased 100-600 fold according to HPLC-analysis. Conclusion: BDP interaction with amine in an aqueous solution was shown to proceed via a proton transfer due to relatively weak forces such as London forces, hydrogen bonding, electrostatic and hydrophobic interactions. In general, the formation of BDP salt complexes with amines in solution determines BDP water solubility. Water-soluble BDP enables to develop hydrophilic dosage forms

The influence of various feed additives on the development of duodenal goblet cells in broilers

A comparative study was carried out on the effect of three drugs on the development of goblet cells in the duodenum of broilers. In the first experiment, day-old broilers Smena-8 were divided into 4 groups. The experimental groups received the phytobiotic Butitan with the main diet: E1-0.25%; E2-0.5% and E3-0.75%. In the second experiment, 3 groups were formed from broilers of the Konkurent cross; additives were added for the first 3 days. The Vetom group received a probiotic based on Bacillus subtilis (0.006%); Enterosgel group – Polymethylsiloxane polyhydrate sorbent (0.008%). Histological studies were carried out in the first experiment at 1, 7 and 42 days, in the second at 1, 4, 49 days. Sections were stained to identify acidic and neutral mucus. The number of goblet cells in the field of view was counted and their density over an area of 1000 μm2 was calculated. By the end of the first experiment, the density of neutral goblet cells in the villi E1 and E2 and crypts E2 and E3 increases by 17% and 7.5%, acidic goblet cells increase in the crypts by 32.6% and 33.1%. The probiotic increased the density of acidic goblet cells in the crypts (64%; P≤0.001) without affecting the villi. Enetrosorbent reduces the density of neutral and increases the density of acidic goblet cells in the mucosa (37.3%). Due to the absence of a pathological picture in the structure of the duodenum, as well as the important role of mucus in the formation of chyme and digestion, we consider the increase in the density of goblet cells and the effect of feed additives as a positive reaction. The study of histological parameters to assess the effect of various feed additives on the body parameters of birds is important, since it shows the functional state of the organs

Uniparental Genetic Heritage of Belarusians: Encounter of Rare Middle Eastern Matrilineages with a Central European Mitochondrial DNA Pool

Ethnic Belarusians make up more than 80% of the nine and half million people inhabiting the Republic of Belarus. Belarusians together with Ukrainians and Russians represent the East Slavic linguistic group, largest both in numbers and territory, inhabiting East Europe alongside Baltic-, Finno-Permic- and Turkic-speaking people. Till date, only a limited number of low resolution genetic studies have been performed on this population. Therefore, with the phylogeographic analysis of 565 Y-chromosomes and 267 mitochondrial DNAs from six well covered geographic sub-regions of Belarus we strove to complement the existing genetic profile of eastern Europeans. Our results reveal that around 80% of the paternal Belarusian gene pool is composed of R1a, I2a and N1c Y-chromosome haplogroups – a profile which is very similar to the two other eastern European populations – Ukrainians and Russians. The maternal Belarusian gene pool encompasses a full range of West Eurasian haplogroups and agrees well with the genetic structure of central-east European populations. Our data attest that latitudinal gradients characterize the variation of the uniparentally transmitted gene pools of modern Belarusians. In particular, the Y-chromosome reflects movements of people in central-east Europe, starting probably as early as the beginning of the Holocene. Furthermore, the matrilineal legacy of Belarusians retains two rare mitochondrial DNA haplogroups, N1a3 and N3, whose phylogeographies were explored in detail after de novo sequencing of 20 and 13 complete mitogenomes, respectively, from all over Eurasia. Our phylogeographic analyses reveal that two mitochondrial DNA lineages, N3 and N1a3, both of Middle Eastern origin, might mark distinct events of matrilineal gene flow to Europe: during the mid-Holocene period and around the Pleistocene-Holocene transition, respectively

Erot spatiaalisissa ja ajallisissa reaktionormeissa kevään ja syksyn fenologisille tapahtumille

For species to stay temporally tuned to their environment, they use cues such as the accumulation of degree-days. The relationships between the timing of a phenological event in a population and its environmental cue can be described by a population-level reaction norm. Variation in reaction norms along environmental gradients may either intensify the envi- ronmental effects on timing (cogradient variation) or attenu- ate the effects (countergradient variation). To resolve spatial and seasonal variation in species’ response, we use a unique dataset of 91 taxa and 178 phenological events observed across a network of 472 monitoring sites, spread across the nations of the former Soviet Union. We show that compared to local rates of advancement of phenological events with the advancement of temperature-related cues (i.e., variation within site over years), spatial variation in reaction normsPeer reviewe