Fixed Drug Eruption due to Ornidazole

Abstract Ornidazole is a nitroimidazole derivative with, anti-trichomoniasis and anti-parasitic properties. Fixed drug eruption (FDE) is a common cutaneous reaction by various drugs. FDE induced by ornidazole has been reported as 4 rd case in English literature. We describe a 40-year-old male patient with ornidazole associated FDE shortly after starting ornidazole therapy for gastroenteritis. Ornidazole therapy was stopped and the patient was treated with topical corticosteroids and systemic antihistamines. The eruption resolved within five days. The rash returned following ornidazole rechallenge. We propose that FDE is a side-effect of ornidazole

Treatment Options in Behcet’s Disease

Abstract: Behçet's disease (BD) is a chronic, relapsing, systemic vasculitis of unknown etiology with the clinical features of mucocutaneous lesions, ocular, vascular, articular, gastrointestinal, urogenital, pulmonary, and neurologic involvement. Mucocutaneous lesions figure prominently in the presentation and diagnosis, and may be considered the hallmarks of BD. Therefore, their recognition may permit earlier diagnosis and treatment. Although, the treatment has become much more effective in recent years, BD is still associated with severe morbidity and considerable mortality. The main aim of the treatment should be the prevention of irreversible organ damage. Therefore, close monitoring, early and appropriate treatment is mandatory to reduce morbidity and mortality. Traditional and current treatments with topical, paraocular and systemic corticosteroids, colchicine, dapsone, cyclosporine, azathioprine, methotrexate, cyclophosphamide and chlorambucil are summarized and recent insights into the pharmacology and effects of thalidomide, tacrolimus (FK-506), interferon-�, anti-TNF- � blocking monoclonal autoantibody (infliximab) and soluble TNF receptor (etanercept) are reviewed. We reviewed the current state of knowledge regarding the therapeutic approaches for BD and designed a stepwise, symptom-based, algorithmic approach, mainly based on controlled studies and our clinical experience in this field to provide a rational framework for selecting the appropriate therapy along the various treatment choices. Key clinical investigations with the status of ongoing clinical trials aimed at addressing the drug’s efficacy, surgical care, and studies that have raised the possibility of new therapeutic uses are also presented. The challenges posed by the drug’s teratogenicity and adverse effects are also considered, if present

Ulcerative Lesions in Behcet's Disease

Ulcerative lesions in Behcet’s disease (BD) are regarded as important manifestation for diagnosis. Various kinds of ulcerative lesions appear in patients with BD. They present as orogenital ulcers, necrotizing vasculitis and pyoderma gengrenosum. Gastrointestinal system involvement (Gis) in Behçet’s disease affects all areas from the esophagus to the anus. Most authors believe that the Gis manifestations of Behçet’s disease should be confined to aphthous ulcers, which can occur throughout the Gis tract. All patients with oro-genital and Gis ulcerations should be fully investigated to establish a definitive diagnosis and eliminate the possibility of an underlying BD

"Sine Phenomenon" in Dermatology

Abstract Background: In dermatology, the term sine is often used in regard to any sign, symptom or finding whose absence would very likely mean uncommon variant of the target disease or condition. Sine phenomenon can be seen in different dermatological diseases such as scleroderma, polymorphic light eruption, dermatomyositis, pellagra, zona, psoriasis, necrobiosis lipoidica, lupus erythematosus, seborrheic keratosis, eccrine hidradenitis and acne fulminans

Efficacy of Intermittent Isotretinoin in Moderate Acne Vulgaris

Abstract Background: Isotretinoin is the only drug that affects almost all factors in acne pathogenesis. Recently, its use for the treatment of chronic mild or moderate acne unresponsive to long-term antibiotic therapy, and with a tendency to cause scarring and lead to negative pyschological effects, has become popular. The aim of the study was to investigate the effectiveness of intermittent isotretinoin treatment in moderate acne

The effectiveness of matrix cauterization with trichloroacetic acid in the treatment of ingrown toenails

Ingrown toenail is an often painful clinical condition that usually affects the big toe. Chemical matricectomy with phenol has a low recurrence rate and good cosmetic results. However, it produces extensive tissue destruction that can result in drainage and delayed healing. Alternatives such as sodium hydroxide and trichloroacetic acid (TCA) have therefore come into vogue. A total of 39 patients with 56 ingrown toenail edges underwent chemical matricectomy with 90% TCA after partial nail avulsion. In most of the patients, adverse effects such as postoperative pain and drainage were minimal. One patient who underwent matricectomy had recurrence in a single nail edge (1.8%) at 12 months follow-up. No recurrence was observed among 38 patients during the mean follow-up period. This was considered to be statistically significant (P < 0.001). Partial nail avulsion followed by TCA matricectomy is a safe, simple, and effective method with low rates of postoperative morbidity and high rates of success

Glutathione S-Transferase, N-Acetyltransferase, Cytochrome P450 Polymorphisms in Patients with Basal Cell Carcinoma

Abstract Background: GST, NAT and CYP polymorphisms have been shown to influence the level of oxidative DNA damage. Also, there is a consensus that ROS play part in the epidermal carcinogenesis