Formation of Quantum Phase Slip Pairs in Superconducting Nanowires

Macroscopic quantum tunneling (MQT) is a fundamental phenomenon of quantum mechanics related to the actively debated topic of quantum-to-classical transition. The ability to realize MQT affects implementation of qubit-based quantum computing schemes and their protection against decoherence. Decoherence in qubits can be reduced by means of topological protection, e.g. by exploiting various parity effects. In particular, paired phase slips can provide such protection for superconducting qubits. Here, we report on the direct observation of quantum paired phase slips in thin-wire superconducting loops. We show that in addition to conventional single phase slips that change superconducting order parameter phase by $2\pi$, there are quantum transitions changing the phase by $4\pi$. Quantum paired phase slips represent a synchronized occurrence of two macroscopic quantum tunneling events, i.e. cotunneling. We demonstrate the existence of a remarkable regime in which paired phase slips are exponentially more probable than single ones

ECTACYTOMETRIC CHARACTERISTIC OF THE DEFORMABILITY OF ERYTHROCYTES UNDER THE CONDITIONS OF THE NORMAL AND STRESSED ERYTHROPOIESIS

Developed and created has been a laboratory unit, intended for the quantitative evaluation of the erythrocyted deformability. The ability of the erythrocytes deformation has been investigated under the normal and stressed erythropoiesis. The results of the work can serve as the base at the development of the series industrial specimen of the ectacytometer. The revealed differences in the erythrocytes deformability under the conditions of the normal and stressed erythropoiesis can be used for the theoretical and practical justification of mechanisms of the output of the mature erythroid cells from the marrow into the blood. The developed technology of the investigation of the erythrocytes deformability with the aid of the ectacytometer can be used for the development of the methodical recommendations on the investigation of the rheological properties of the blood by the method of ectacytometryAvailable from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio

Methods and apparatus for generating terahertz radiation

Apparatus and methods for generating radiation via difference frequency generation (DFG). In one exemplary implementation, a quantum cascade laser (QCL) has a significant second-order nonlinear susceptibility (?(2)) integrated in an active region of the QCL. The QCL is configured to generate first radiation at a first frequency ?1, second radiation at a second frequency ?2, and third radiation at a third frequency ?3=?1??2 based on difference frequency generation (DFG) arising from the non-linear susceptibility. In one aspect, the QCL may be configured to generate appreciable THz radiation at room temperature.U

Methods and apparatus for generating terahertz radiation

Apparatus and methods for generating radiation via difference frequency generation (DFG). In one exemplary implementation, a quantum cascade laser (QCL) has a significant second-order nonlinear susceptibility (?(2)) integrated in an active region of the QCL. The QCL is configured to generate first radiation at a first frequency ?1, second radiation at a second frequency ?2, and third radiation at a third frequency ?3=?1??2 based on difference frequency generation (DFG) arising from the non-linear susceptibility. In one aspect, the QCL may be configured to generate appreciable THz radiation at room temperature.U

Cell Surface Transglutaminase Promotes RhoA Activation via Integrin Clustering and Suppression of the Src–p190RhoGAP Signaling Pathway

Tissue transglutaminase (tTG) is a multifunctional protein that serves as cross-linking enzyme and integrin-binding adhesion coreceptor for fibronectin on the cell surface. Previous work showed activation of small GTPase RhoA via enzymatic transamidation by cytoplasmic tTG. Here, we report an alternative nonenzymatic mechanism of RhoA activation by cell surface tTG. Direct engagement of surface tTG with specific antibody or the fibronectin fragment containing modules I(6)II(1,2)I(7-9) increases RhoA-GTP levels. Integrin-dependent signaling to RhoA and its downstream target Rho-associated coiled-coil containing serine/threonine protein kinase (ROCK) is amplified by surface tTG. tTG expression on the cell surface elevates RhoA-GTP levels in nonadherent and adherent cells, delays maximal RhoA activation upon cell adhesion to fibronectin and accelerates a rise in RhoA activity after binding soluble integrin ligands. These data indicate that surface tTG induces integrin clustering regardless of integrin–ligand interactions. This notion is supported by visualization of integrin clusters, increased susceptibility of integrins to chemical cross-linking, and biochemical detection of large integrin complexes in cells expressing tTG. In turn, integrin aggregation by surface tTG inhibits Src kinase activity and decreases activation of the Src substrate p190RhoGAP. Moreover, pharmacological inhibition of Src kinase reveals inactivation of Src signaling as the primary cause of elevated RhoA activity in cells expressing tTG. Together, these findings show that surface tTG amplifies integrin-mediated signaling to RhoA/ROCK via integrin clustering and down-regulation of the Src–p190RhoGAP regulatory pathway