Blood oxygen level dependent functional magnetic resonance imaging of hippocampal subfields and cortical brain areas during cued recall associative memory

The use of functional magnetic resonance imaging (fMRI) presents a trade-off between spatial resolution and whole-brain analysis in current literature. The current study aims to address this compromise by utilizing Blood Oxygen Level Dependent (BOLD) fMRI on an ultrahigh resolution 7T scanner. The current study involves an associative memory task adapted from De Shetler and Rissman (2017), which was conducted on 22 healthy young adults. The analysis includes measuring whole-brain activation and percent signal change from regions of interest, including dentate gyrus, CA1, CA3, and subiculum. The findings indicate multiple regions in the cortex are involved in successful retrieval, but hippocampal subfield activity does not differ according to retrieval condition.Bachelor of Scienc

Development of Novel Organometallic Compounds as Antibiotics

Antimicrobial resistance is an emerging healthcare problem. More than 2.8 million cases of antibiotic-resistant infections are reported each year in the U.S., and the emergence of new antibiotic-resistant microbes is a growing concern. Most scientific research is focused on the exploration and development of common antibiotics, but the search for new drug compounds is a necessity. Organometallic compounds are a class of drugs that have largely been overlooked in antibiotic research. These compounds have unique structures that have an impact on microbial growth. In this study, a series of organometallic compounds were first studied using Kirby-Bauer disk diffusion assays. The compounds were further analyzed using microdilution assays. The half maximal inhibitory concentration (IC50) and Minimum Inhibitory Concentration (MIC) were determined for all organometallic compounds. The results of this study showed that this series of organometallic compounds are effective against Gram-positive bacteria and organometallic compounds with silver ion complexes showed greater inhibition and broader susceptibility profiles overall