3 research outputs found
Crystal structure of trisÂ(4,7-diphenyl-1,10-phenanthroline-Îș2N,NâČ)cobalt(III) trisÂ(hexaÂfluoroÂphosphate) monohydrate
The title compound, [Co(C72H48N6)](PF6)3·H2O, crystallizes with one tripositive complex molÂecule, three hexaÂfluoroÂphosphate anions and one solvent molÂecule of water in the asymmetric unit. The N6 coordination set around the central CoIII atom defines a distorted octaÂhedral environment. Four fluorine atoms of one hexaÂfluoroÂphosphate anion are disordered over two sets of positions with site-occupancy factors of 0.697â
(5) and 0.303â
(5). In the crystal, interÂmolecular ÏâÏ stacking interÂactions, CâH...Ï, CâH...F and OâH...F and interÂactions are present
Structurally Simple Osmium(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy in the Near Infrared**
Five osmium(II) polypyridyl complexes of the general formula [Os(4,7âdiphenylâ1,10âphenanthroline)L] were synthesized as photosensitizers for photodynamic therapy by varying the nature of the ligand L. Thanks to the pronounced Ïâextended structure of the ligands and the heavy atom effect provided by the osmium center, these complexes exhibit a high absorption in the nearâinfrared (NIR) region (up to 740â
nm), unlike related ruthenium complexes. This led to a promising phototoxicity in vitro against cancer cells cultured as 2D cell layers but also in multicellular tumor spheroids upon irradiation at 740â
nm. The complex [Os(4,7âdiphenylâ1,10âphenanthroline)(2,2âČâbipyridine)] was found to be the most efficient against various cancer cell lines, with high phototoxicity indexes. Experiments on CT26 tumorâbearing BALB/c mice also indicate that the Os complexes could significantly reduce tumor growth following 740â
nm laser irradiation. The high phototoxicity in the biological window of this structurally simple complex makes it a promising photosensitizer for cancer treatment
Structurally Simple Osmium(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy in the Near Infrared
Five osmium(II) polypyridyl complexes of the general formula [Os(4,7-diphenyl-1,10-phenanthroline)2L]2+ were synthesized as photosensitizers for photodynamic therapy by varying the nature of the ligand L. Thanks to the pronounced Ï-extended structure of the ligands and the heavy atom effect provided by the osmium center, these complexes exhibit a high absorption in the near infrared (NIR) region (up to 740 nm), unlike related ruthenium complexes. This led to promising phototoxicity in vitro against cancer cells cultured as 2D cell layers but also in multicellular tumor spheroids upon irradiation at 740 nm. The complex [Os(4,7-diphenyl-1,10-phenanthroline)2(2,2â-bipyridine)]2+ was found to be the most efficient against various cancer cell lines, with high phototoxicity indexes. Experiments on CT26 tumor-bearing BALB/c mice also indicate that the Os(II) complexes could significantly reduce tumor growth under 740 nm laser irradiation. The high phototoxicity in the biological window of this structurally simple complex makes it a promising photosensitizer for cancer treatment