Latent Autoimmune Diabetes in Adults Associated with Von Recklinghausen’s Disease (Neurofibromatosis Type 1)

Introduction: Endocrine disorders during Von Recklinghausen’s Disease or neurofibromatosis type 1 (NF1) are rare and particularly observed in children. However, autoimmune diabetes mellitus (DM) remains exceptional and unusual during this phacomatosis. We report an original case of Latent Autoimmune Diabetes in Adults (LADA) associated with NF1.Case Report: A 32-year-old Tunisian male, known to have NF1 since childhood, was admitted for significant recent weight loss (10 kg in one month) with high blood glucose levels. The biological tests confirmed the diagnosis of DM with marked ketoacidosis: fast blood glucose at 16 mmol/l, postprandial glucose at 21 mmol/l, and HbA1c at 9.9%. Radiological and endoscopic investigations did not indicate pancreatic and/or duodenal tumors. Anti-GAD and anti-IA2 autoantibodies were positively confirming the diagnosis of LADA. The assessment of degenerative complications and screening for possible other autoimmune diseases were negative. The evolution was favorable under intensive insulinotherapy.Conclusion: The association of DM type 1 with NF1 remains exceptional and only four cases are found in the literature, all pediatrics. Our observation is, to our knowledge, the first reporting this association in adult (LADA with NF1)

A New Equation Relating the Viscosity Arrhenius Temperature and the Activation Energy for Some Newtonian Classical Solvents

In transport phenomena, precise knowledge or estimation of fluids properties is necessary, for mass flow and heat transfer computations. Viscosity is one of the important properties which are affected by pressure and temperature. In the present work, based on statistical techniques for nonlinear regression analysis and correlation tests, we propose a novel equation modeling the relationship between the two parameters of viscosity Arrhenius-type equation, such as the energy (Ea) and the preexponential factor (As). Then, we introduce a third parameter, the Arrhenius temperature (TA), to enrich the model and the discussion. Empirical validations using 75 data sets of viscosity of pure solvents studied at different temperature ranges are provided from previous works in the literature and give excellent statistical correlations, thus allowing us to rewrite the Arrhenius equation using a single parameter instead of two. In addition, the suggested model is very beneficial for engineering data since it would permit estimating the missing parameter value, if a well-established estimate of the other parameter is readily available