8 research outputs found

    Biallelic variants in KIF14 cause intellectual disability with microcephaly.

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    Kinesin proteins are critical for various cellular functions such as intracellular transport and cell division, and many members of the family have been linked to monogenic disorders and cancer. We report eight individuals with intellectual disability and microcephaly from four unrelated families with parental consanguinity. In the affected individuals of each family, homozygosity for likely pathogenic variants in KIF14 were detected; two loss-of-function (p.Asn83Ilefs*3 and p.Ser1478fs), and two missense substitutions (p.Ser841Phe and p.Gly459Arg). KIF14 is a mitotic motor protein that is required for spindle localization of the mitotic citron rho-interacting kinase, CIT, also mutated in microcephaly. Our results demonstrate the involvement of KIF14 in development and reveal a wide phenotypic variability ranging from fetal lethality to moderate developmental delay and microcephaly

    When the laughter dies

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    WHEN THE LAUGHTER DIES, is a twenty-minute documentary dealing with the lives of inactive comedians. We have as our subjects, Adelaida Fernando (Dely Atayatayan) and Perfecto Leonsio Peck (Tugak) to represent an era of comedy and comedians that have reached their prime. The documentary begins with a recount of the start of their respective careers. We trace their beginning in bodabil, the continuation of their career during the Second World War, and even after the Liberation. Such citations shall help to establish their status as comedians, duly recognized by the industry. In the course of the video, the following insights are gained: 1. The value of being a comedian to them as shown by their financial gain and fulfillment of becoming famous and recognized as individuals who make people laugh. 2. These comedians, though inactive, do not refuse to call themselves retired. They continually see themselves as part of the industry and show an enjoyment in performing for the camera. 3. Two possible paths an actor may take after showbiz: a. Enter a different profession as Peck Pinon did when he went into painting and succeeded. b. Remain idle as Dely Atayatayan. 4. Despite the retirement , these people are not to be pitied but deserve respect and dignity due to them as veterans in the industry

    Measuring entrepreneurial attitude and entrepreneurial intention of ABM grade XII, Senior High School Students of Divine Word Colleges in Region I, Philippines

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    The study wants to determine the relationship between entrepreneurial attitude and intention to do businessInternational audienceThe purpose of the study was to determine the level of entrepreneurial attitude and entrepreneurial intentions of ABM Grade XII of Senior High School students of Divine Word Colleges in Region I, Philippines. The study uses quantitative descriptive research design and explanation research to describe and explain the entrepreneurial attitude and intentions of the students. In order to gather the data, questionnaires were used and the respondents were all ABM grade XII of the three schools, a total of 162 students. The findings reveal that as a whole entrepreneurial attitude of students is high and their entrepreneurial intention is also high. In terms of its correlation, the study found that there is a significant relationship between entrepreneurial attitude and intention

    Measuring Environmental Attitude and Environmental Behavior of Senior High School Students of Divine Word Colleges in Region I, Philippines

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    International audienceThe study was motivated by the realities of climate change and its effect on the human life. The study argues that environmental problems are caused by human attitude toward environment and such attitude affects environmental behavior. In order to support such theory, the literature and studies were reviewed. The data gathered through questionnaires and 400 students were given the questionnaires. The descriptive correlational study was utilized to determine the extent of the correlation between environmental attitude and environmental behavior of the Senior High School Students of Divine Word Colleges in Region I, Philippines. The study revealed that anthropocentric attitude and eco-centric attitude were found to be dominant among students. However, the correlation was found only between eco-centric attitude and environmental behavior along environmental movement activism and personal conservation behavior, while anthropocentric and human dominance over nature attitude do not correlate to the environmental behavior. Keywords: Environmental behavior, environmental attitude, anthropocentric, eco-centric, human dominance over nature, environmental movement activism, personal conservation behavior. Chapter I: The Problem Rationale Environmental problems have become a serious concern of all human being on the planet. Why is it becoming serious concern? People have seen the connection between the environmental disaster and quality of human life. Quality of life has been affected by climate change. EPA (2016) mentions several impacts of climate change such as the increase of warming temperatures, changes in precipitation, and increases in the frequency of extreme weather events and the rising of sea levels. As a result, these affect the food that we eat, water we drink, the air we breathe, and the weather we experience. WHO (2016) estimated and predicted that between 2030 and 2050, the climate change is expected to cause approximately 250,000 additional deaths per year from malnutrition, diarrhea and heat stress. Such prediction causes alarm and immediate action. It cannot be ignored but it has to be solved but the question here is how can we solve i

    Measuring Environmental Attitude and Environmental Behavior of Senior High School Students of Divine Word Colleges in Region I, Philippines

    No full text
    International audienceThe study was motivated by the realities of climate change and its effect on the human life. The study argues that environmental problems are caused by human attitude toward environment and such attitude affects environmental behavior. In order to support such theory, the literature and studies were reviewed. The data gathered through questionnaires and 400 students were given the questionnaires. The descriptive correlational study was utilized to determine the extent of the correlation between environmental attitude and environmental behavior of the Senior High School Students of Divine Word Colleges in Region I, Philippines. The study revealed that anthropocentric attitude and eco-centric attitude were found to be dominant among students. However, the correlation was found only between eco-centric attitude and environmental behavior along environmental movement activism and personal conservation behavior, while anthropocentric and human dominance over nature attitude do not correlate to the environmental behavior. Keywords: Environmental behavior, environmental attitude, anthropocentric, eco-centric, human dominance over nature, environmental movement activism, personal conservation behavior. Chapter I: The Problem Rationale Environmental problems have become a serious concern of all human being on the planet. Why is it becoming serious concern? People have seen the connection between the environmental disaster and quality of human life. Quality of life has been affected by climate change. EPA (2016) mentions several impacts of climate change such as the increase of warming temperatures, changes in precipitation, and increases in the frequency of extreme weather events and the rising of sea levels. As a result, these affect the food that we eat, water we drink, the air we breathe, and the weather we experience. WHO (2016) estimated and predicted that between 2030 and 2050, the climate change is expected to cause approximately 250,000 additional deaths per year from malnutrition, diarrhea and heat stress. Such prediction causes alarm and immediate action. It cannot be ignored but it has to be solved but the question here is how can we solve i
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