Effects of ziprasidone, SCH23390 and SB277011 on spatial memory in the Morris water maze test in naive and MK-801 treated mice

Conclusions: The second-generation antipsychotic drug ziprasidone and D1 antagonist SCH23390, but not the D3 antagonist SB277011, might be clinically useful for the treatment of cognitive impairments in patients with schizophrenia. (C) 2015 Elsevier Inc. All rights reserved

Effects of long-term treatment with haloperidol, clozapine and aripiprazole on mice isolated vas deferens

These results revealed that induced contractions of vas deferens were affected after chronic treatment with haloperidol and clozapine but not aripiprazole. Serotonergic, noradrenergic and purinergic receptors may, at least in part, contribute to changes in vas deferens contractions in mice with chronic treatment of haloperidol and clozapine but not aripiprazole

The Influence of Atypical Antipsychotic Drugs on Vas Deferens in Mice

Objective: Several classes of prescription drugs contribute to the sexual dysfunction in men that have been found especially in the antipsychotic drugs. Varieties of mechanisms are likely to contribute to the antipsychotic-related sexual dysfunction including hyperprolactinemia and antagonism of some neurotransmitter receptors. Implications for future research, atypical antipsychotics should be strongly taken into account. Material and Method: Male mice were treated by intraperitoneal injection (IP injection) of drugs for 21 days. The effects of saline, quetiapine, olanzapine, and risperidone were investigated on serotonin, noradrenaline (NA), adenosine triphosphate (ATP) and potassium chloride (KCl) which induced contractions of the vas deferens. Results: Serotonin-induced contractile responses were significantly increased in the epididymal and prostatic portion of the vas deferens obtained from the risperidone-treated group. The E-max value for serotonin was significantly higher in prostatic and epididymal portions of the mice vas deferens obtained from the risperidone-treated group than the control group. However, olanzapine and quetiapine treatment had no effect on serotonin responses in both epididymal and prostatic portions of the mice vas deferens. The risperidone treatment significantly inhibited both noradrenaline and ATP-induced contractions of the prostatic and epididymal portions of the mice vas deferens. There were no significant differences in KCl-induced contractile responses among the groups. Conclusion: It can be concluded that only risperidone could impair sexual competence in the male mice. Serotonergic, noradrenergic and purinergic receptors may contribute to the changes in vas deferens contractions in mice with chronic treatment of risperidone but not olanzapine and quetiapine. This study will help clinicians make a purpose-oriented choice of which antipsychotic drug to use