Hypersensitivity reaction after intravenous administration of meloxicam in dogs - case report

ABSTRACT Although rarely reported in veterinary medicine, this article shows three cases of dogs that presented anaphylactic reactions after intravenous administration of meloxicam at therapeutic doses. Three dogs of different breeds and ages were submitted to anesthesia for surgical procedures of ovariohysterectomy and repair of patellar luxation. The animals were classified as ASA I and did not present changes in clinical and laboratory tests. All dogs were anesthetized and monitored by anesthesiologists, with careful multiparametric evaluation. Near the end of the procedures, meloxicam was administered intravenously in all dogs, and the drug used had the same commercial presentation and concentration, but with different lot numbers and with different months. For less than a minute, the animals showed significant hypotension, with pressure values close to 30 mmHg or inaudible by Doppler. The animals had no skin signs, only hypotension and a decrease in heart rate in one of them. All dogs were immediately treated with intravenous ephedrine and atropine in the bradycardic patient. After the emergency treatment, the dogs showed stabilized vital signs, with no complications or need for additional intervention. After the event, the three dogs showed no signs of clinical, behavioral or laboratory changes

Theoretical study of lepton events in the atmospheric neutrino experiments at SuperK

Super-Kamiokande has reported the results for the lepton events in the atmospheric neutrino experiment. These results have been presented for a 22.5kT water fiducial mass on an exposure of 1489 days, and the events are divided into sub-GeV, multi-GeV and PC events. We present a study of nuclear medium effects in the sub-GeV energy region of atmospheric neutrino events for the quasielastic scattering, incoherent and coherent pion production processes, as they give the most dominant contribution to the lepton events in this energy region. We have used the atmospheric neutrino flux given by Honda et al. These calculations have been done in the local density approximation. We take into account the effect of Pauli blocking, Fermi motion, Coulomb effect, renormalization of weak transition strengths in the nuclear medium in the case of the quasielastic reactions. The inelastic reactions leading to production of leptons along with pions is calculated in a $\Delta$- dominance model by taking into account the renormalization of $\Delta$ properties in the nuclear medium and the final state interaction effects of the outgoing pions with the residual nucleus. We present the results for the lepton events obtained in our model with and without nuclear medium effects, and compare them with the Monte Carlo predictions used in the simulation and the experimentally observed events reported by the Super-Kamiokande collaboration.Comment: 23 pages, 13 figure

The Sudbury Neutrino Observatory

The Sudbury Neutrino Observatory is a second generation water Cherenkov detector designed to determine whether the currently observed solar neutrino deficit is a result of neutrino oscillations. The detector is unique in its use of D2O as a detection medium, permitting it to make a solar model-independent test of the neutrino oscillation hypothesis by comparison of the charged- and neutral-current interaction rates. In this paper the physical properties, construction, and preliminary operation of the Sudbury Neutrino Observatory are described. Data and predicted operating parameters are provided whenever possible.Comment: 58 pages, 12 figures, submitted to Nucl. Inst. Meth. Uses elsart and epsf style files. For additional information about SNO see http://www.sno.phy.queensu.ca . This version has some new reference

Measurement of the νe and total 8B solar neutrino fluxes with the Sudbury Neutrino Observatory phase-III data set

This paper details the solar neutrino analysis of the 385.17-day phase-III data set acquired by the Sudbury Neutrino Observatory (SNO). An array of 3He proportional counters was installed in the heavy-water target to measure precisely the rate of neutrino-deuteron neutral-current interactions. This technique to determine the total active 8B solar neutrino flux was largely independent of the methods employed in previous phases. The total flux of active neutrinos was measured to be 5.54-0.31+0.33(stat.)-0.34+0.36(syst.)×106 cm-2 s-1, consistent with previous measurements and standard solar models. A global analysis of solar and reactor neutrino mixing parameters yielded the best-fit values of Δm2=7.59-0.21+0.19×10 -5eV2 and θ=34.4-1.2+1.3degrees

SOOT AND RADIATION IN COMBUSTING BOUNDARY LAYERS

In most fires thermal radiation is the dominant mode of heat transfer. Carbon particles within the fire are responsible for most of this emitted radiation and hence warrant quantification. As a first step toward understanding thermal radiation in full scale fires, an experimental and theoretical study is presented for a laminar combusting boundary layer. Carbon particulate volume fraction profiles and approximate particle size distributions are experimentally determined in both free and forced flow for several hydrocarbon fuels and PMMA (polymethylmethacrylate). A multiwavelength laser transmission technique determines a most probable radius and a total particle concentration which are two unknown parameters in an assumed Gauss size distribution. A sooting region is observed on the fuel rich side of the main reaction zone. For free flow, all the flames are in air, but the free stream ambient oxygen mass fraction is a variable in forced flow. To study the effects of radiation heat transfer, a model is developed for a laminar combusting boundary layer over a pyrolyzing fuel surface. An optically thin approximation simplifies the calculation of the radiant energy flux at the fuel surface. For the free flames in air, the liquid fuel soot volume fractions, f/sub v/, range from f/sub v/ approx. 10/sup -7/ for n-heptane, a paraffin, to f/sub v/ approx. 10/sup -7/ for toluene, an aromatic. The PMMA soot volume fractions, f/sub v/ approx. 5 x 10/sup -7/, are approximately the same as the values previously reported for pool fires. Soot volume fraction increases monotonically with ambient oxygen mass fraction in the forced flow flames. For all fuels tested, a most probable radius between 20 nm and 80 nm is obtained which varies only slightly with oxygen mass fraction, streamwise position, or distance normal to the fuel surface. The theoretical analysis yields nine dimensionless parameters, which control the mass flux rate at the pyrolyzing fuel surface

Soot profiles in boundary-layer flames

Carbon particulate volume fractions and approximate particle size distributions are measured in a free laminar combusting boundary layer for liquid hydrocarbon fuels (n-heptane, iso-octane, cyclohexane, cyclohexene, toluene) and polymethylmethacrylate (PMMA). A multiwavelength laser transmission technique determines a most probable radius and the total particle concentration, which are two parameters in an assumed form for the size distribution. In the combusting boundary layer, a sooting region exists between the pyrolyzing fuel surface and the flame zone. The liquid fuel soot volume fractions, f/sub v/, range from f/sub v/ approx. 10/sup -7/ for n-heptane, a paraffin, to f/sub v approx. 10/sup -5/ for toluene, an aromatic. The PMMA volume fractions, f/sub v/ approx. 5 X 10/sup -7/, are approximately the same as the values previously reported for pool fires. The soot volume fractions increase with height; convection of carbon particles downstream widens the soot region with height. For all fuels tested, the most probable radius is between 20 nm and 50 nm, and it changes only slightly with height and distance from the fuel surface