Evaluation of the stress–strain curve of metallic materials by spherical indentation

AbstractA method for deducing the stress–strain uniaxial properties of metallic materials from instrumented spherical indentation is presented along with an experimental verification.An extensive finite element parametric analysis of the spherical indentation was performed in order to generate a database of load vs. depth of penetration curves for classes of materials selected in order to represent the metals commonly employed in structural applications. The stress–strain curves of the materials were represented with three parameters: the Young modulus for the elastic regime, the stress of proportionality limit and the strain-hardening coefficient for the elastic–plastic regime.The indentation curves simulated by the finite element analyses were fitted in order to obtain a continuous function which can produce accurate load vs. depth curves for any combination of the constitutive elastic–plastic parameters. On the basis of this continuous function, an optimization algorithm was then employed to deduce the material elastic–plastic parameters and the related stress–strain curve when the measured load vs. depth curve is available by an instrumented spherical indentation test.The proposed method was verified by comparing the predicted stress–strain curves with those directly measured for several metallic alloys having different mechanical properties.This result confirms the possibility to deduce the complete stress–strain curve of a metal alloy with good accuracy by a properly conducted instrumented spherical indentation test and a suitable interpretation technique of the measured quantities

KITLG (KIT ligand)

Review on KITLG (KIT ligand), with data on DNA, on the protein encoded, and where the gene is implicated

Familial gastrointestinal stromal tumors (GISTs)

Review on Familial gastrointestinal stromal tumors (GISTs), with data on clinics, and the genes involved

KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog)

Review on KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), with data on DNA, on the protein encoded, and where the gene is implicated

Piebaldism

Review on Piebaldism, with data on clinics, and the genes involved

Comportamento a fatica di strutture meccaniche in piena scala: risultati sperimentali e previsioni

Il lavoro si propone di presentare le principali attività di ricerca svolte, negli ultimi anni, presso il Dipartimento di Ingegneria Meccanica, Nucleare e della Produzione (DIMNP) dell’Università di Pisa, anche in collaborazione con l’Università di Trento, nel campo della resistenza a fatica delle strutture meccaniche, in particolare per quanto riguarda la conduzione di “test” su componenti in piena scala e la loro interpretazione. Viene quindi condotta un’illustrazione di alcune recenti campagne sperimentali (Es.: giunzioni filettate in acciaio, elementi di sospensione in alluminio, ingranaggi ad elevate prestazioni), alla quale segue una descrizione delle attività di caratterizzazione di base e di modellazione condotte al fine di costituire una adeguata base di conoscenze per la interpretazione. Infine, vengono analizzati i risultati ottenuti, evidenziando alcuni problemi aperti, sia sul piano concettuale che su quello applicativo

Integral method coefficients for the ring-core technique to evaluate non-uniform residual stresses

The ring-core technique allows for the determination of non-uniform residual stresses from the surface up to relatively higher depths as compared to the hole-drilling technique. The integral method, which is usually applied to hole-drilling, can also be used for elaborating the results of the ring-core test since these two experimental techniques share the axisymmetric geometry and the 0°–45°–90° layout of the strain gage rosette. The aim of this article is to provide accurate coefficients which can be used for evaluating the residual stress distribution by the ring-core integral method. The coefficients have been obtained by elaborating the results of a very refined plane harmonic axisymmetric finite element model and verified with an independent three-dimensional model. The coefficients for small depth steps were initially provided, and then the values for multiple integer step depths were also derived by manipulating the high-resolution coefficient matrices, thus showing how the present results can be practically used for obtaining the residual stresses according to different depth sequences, even non-uniform. This analysis also allowed the evaluation of the eccentricity effect which turned out to be negligible due to the symmetry of the problem. An applicative example was reported in which the input of the experimentally measured relaxed strains was elaborated with different depth resolutions, and the obtained residual stress distributions were compared

Modello di tenuta della flangia bullonata, senza guarnizione, mediante l'analogia della meccanica della frattura di una fessura parzialmente aperta

I compressori centrifughi di elevate dimensioni non permettono l'utilizzo di guarnizioni deformabili, per cui le due meta della flangia di connessione sono forzate mediante bullonatura e la tenuta e affidata al contatto completo delle due superfici. La previsione della pressione di perdita e un aspetto di progetto di notevole interesse per questa tecnologia. L'azione della pressione interna sollecita la separazione delle superfici della flangia, che invece e contrastata dall'azione di serraggio dei bulloni. Il presente lavoro propone un modello per prevedere la condizione di perdita, basato sulla meccanica della frattura. Dato che le due superfici della flangia sono semplicemente a contatto, esse costituiscono una vera e propria fessura parzialmente aperta. Come ben noto il fattore di intensificazione di una fessura parzialmente aperta e nullo. Imponendo che le due superfici siano parzialmente separate ad una distanza fino al bordo del foro del bullone (che offre un canale di fuoriuscita per il fluido in pressione), e imponendo la condizione di fattore di intensificazione nullo, e possibile determinare la pressione di perdita, analiticamente, mediante la tecnica delle "weight functions" (o "funzioni peso"). Il presente lavoro riporta una positiva validazione del modello proposto mediante sia simulazione numerica sia risultati sperimentali in piena scala e in scala ridotta. Il modello analitico proposto offre uno strumento di progetto di immediata implementazione per comparare diverse geometrie di flangia bullonata

High temperature fatigue testing of gas turbine blades

Abstract With the increasing use of renewable energy sources, Gas Turbines (GTs) are currently required to accomplish more flexible operations for supplying the back-up energy. As a result, thermo-mechanical fatigue issues in the GTs components are emphasized. In this paper, the design of a novel rig for assessing the fatigue behavior in the trailing edge of full scale GTs blades is presented. Based on a detailed Finite Element (FE) analysis of the blade response under thermo-mechanical loads, it is demonstrated that the stress and strain cycles arising in this area during a start-up/shut-down transient can be accurately reproduced by clamping the blade in the shank zone and applying a transversal load to the trailing edge. It is also shown that the stress/strain states can be obtained using a Test Article (TA) extracted from the actual blade. In this configuration, the load magnitude and direction, and the distance of the application point from the blade platform are the test control parameters. A FE model simulating the TA test is developed to determine the test parameters. A tooling for clamping and loading the TA is finally proposed along with a rig apparatus consisting of standard equipment used in material testing

Intronless WNT10B-short variant underlies new recurrent allele-specific rearrangement in acute myeloid leukaemia.

Defects in the control of Wnt signaling have emerged as a recurrent mechanism involved in cancer pathogenesis and acute myeloid leukaemia (AML), including the hematopoietic regeneration-associated WNT10B in AC133bright leukaemia cells, although the existence of a specific mechanism remains unproven. We have obtained evidences for a recurrent rearrangement, which involved the WNT10B locus (WNT10BR) within intron 1 (IVS1) and flanked at the 5' by non-human sequences whose origin remains to be elucidated; it also expressed a transcript variant (WNT10BIVS1) which was mainly detected in a cohort of patients with intermediate/unfavorable risk AML. We also identified in two separate cases, affected by AML and breast cancer respectively, a genomic transposable short form of human WNT10B (ht-WNT10B). The intronless ht-WNT10B resembles a long non-coding RNA (lncRNA), which suggests its involvement in a non-random microhomology-mediated recombination generating the rearranged WNT10BR. Furthermore, our studies supports an autocrine activation primed by the formation of WNT10B-FZD4/5 complexes in the breast cancer MCF7 cells that express the WNT10BIVS1. Chemical interference of WNT-ligands production by the porcupine inhibitor IWP-2 achieved a dose-dependent suppression of the WNT10B-FZD4/5 interactions. These results present the first evidence for a recurrent rearrangement promoted by a mobile ht-WNT10B oncogene, as a relevant mechanism for Wnt involvement in human cancer