Online freelancing and impact sourcing: Examining the inclusive development potential of online service work in the Philippines

Online freelancing and impact sourcing have in recent years emerged as new models for offshore service delivery. Both have the potential of spreading the gains of online service work. Based on empirical research in the Philippines, this article examines how both models integrate outlying areas and more marginalized workers in international networks of online service delivery. The different models of information and communication technologies (ICT)-enabled service delivery were observed to rely on the same pool of labor, thereby limiting the broader distribution of its gains. The article concludes that ICT4D research can benefit from an inclusive development lens when examining the beneficiaries and users of new (information) technologies and their longer-term prospects for income generation

Invisible, scattered, difficult to contact: union challenges and strategies to engage contract workers in developing countries

This report is the result of a study of how trade unions can respond to the challenges of dealing with an increasingly flexible and fragmented labour force. A literature study, a survey and open interviews in four countries were carried out to identify how CNV partner unions can support workers who fall outside of their traditional scope. The number of contract workers in many partner countries has increased rapidly over the past five years and is expected to continue growing in the coming years. This report argues that contract workers are the prime group of informal workers who need to be targeted by trade unions. A widespread use of contract labour affects union strength and undermines the ability of (regular) workers to negotiate with their employer. New strategies should be developed to incorporate contract workers within existing union structures and cater to their specific needs. The most immediate problems facing contract workers are related to income and benefits. These issues can be addressed by enhancing the workers’ level of organisation. Established trade unions can provide guidance, training and other forms of support to enhance their capacity to develop organizational structures, management and leadership. Cooperation and partnerships with other civil society organizations are necessary in order to cater for their multiple needs

Digital reputation, skills and uncertainty reduction on global digital labour platforms

Digital labour platforms have become increasingly common for the trade of a range of digitally transferable services. To help participants mitigate the uncertainty that is inherent to trading on digital platforms, feedback mechanisms have become the main tool to gauge the ‘performed’ quality and reliability of platform participants. Based on an analysis of 750 written feedback texts, this article first examines which freelancer qualities (technical skills, generic skills or personal competences) matter most to clients and, therefore, are instrumental to the building of a freelancer’s digital reputation on a platform and, second, how exactly these feedback texts help reduce uncertainty when trading via a platform. Herewith, this paper adds to a deeper understanding of the ‘rules of the game’ on digital labour platforms

Identification of the high-risk group for metastasis of gastric cancer cases by vascular endothelial growth factor receptor-1 overexpression in peripheral blood

Identification of an isolated tumour cell with metastatic ability is important for predicting the recurrence and prognosis of gastric cancer. A biological marker for evaluating the metastatic ability of gastric cancer cells has not yet been identified. We assessed vascular endothelial growth factor receptor-1 mRNA expression by quantitative real-time reverse transcriptase-polymerase chain reaction. Vascular endothelial growth factor receptor-1 mRNA in peripheral blood was more highly expressed in perioperative metastasis-positive and postoperative recurrence cases than in normal control cases, early cancer cases and nonmetastatic advanced cancer cases. The peripheral blood vascular endothelial growth factor receptor-1 mRNA-positive group was associated with advanced clinical stage, deep invasion beyond the muscularis propria, lymphatic involvement, vascular involvement, lymph node metastasis, positive peritoneal lavage cytology, preoperative metastasis and postoperative recurrence. Flow cytometry analysis disclosed that vascular endothelial growth factor receptor-1 expressing cells in the peripheral blood were more abundant in cancer cases with metastases than in cases without metastases. Our data suggest that the amount of positive cells may provide information on the clinical features of gastric cancer, especially in regard to gastric cancer metastasis

Enhanced tumour antiangiogenic effects when combining gefitinib with the antivascular agent ZD6126

Current experimental and clinical knowledge supports the optimisation of endothelial cell targeting using a strategy combining anti-EGFR drugs with antivascular agents. The purpose of the present study was to examine the effects of the association of ZD6126, an antivascular microtubule-destabilising agent, with gefitinib and irradiation on the growth of six head and neck human cancer cell lines xenografted in nude mice and to study predictive and molecular factors responsible for antitumour effects. CAL33- and Hep-2-grafted cell lines were the most sensitive to ZD6126 treatment, with VEGF levels significantly higher (P=0.0336) in these tumour xenografts compared to Detroit 562- and CAL27-grafted cell lines with relatively low VEGF levels that were not sensitive to ZD6126. In contrast, neither IL8 levels nor EGFR expression was linked to the antitumour effects of ZD6126. ZD6126 in combination with gefitinib resulted in a synergistic cytotoxic interaction with greater antitumour effects than gefitinib alone. The synergistic interaction between ZD6126 and gefitinib was corroborated by a significant decrease in CD31 labelling. The present study may serve for future innovative clinical applications, as it suggests that VEGF tumour levels are possible predictors for ZD6126 antitumour efficacy. It also supports the notion of antitumour supra-additivity when combining gefitinib and ZD6126, and identifies neoangiogenesis as the main determinant of this synergistic combination