A Vector-Integration-to-Endpoint Model for Performance of Viapoint Movements

Viapoint (VP) movements are movements to a desired point that are constrained to pass through an intermediate point. Studies have shown that VP movements possess properties, such as smooth curvature around the VP, that are not explicable by treating VP movements as strict concatenations of simpler point-to-point (PTP) movements. Such properties have led some theorists to propose whole-trajectory optimization models, which imply that the entire trajectory is pre-computed before movement initiation. This paper reports new experiments conducted to systematically compare VP with PTP trajectories. Analyses revealed a statistically significant early directional deviation in VP movements but no associated curvature change. An explanation of this effect is offered by extending the Vector-Integration-To-Endpoint (VITE) model (Bullock and Grossberg, 1988), which postulates that voluntary movement trajectories emerge as internal gating signals control the integration of continuously computed vector commands based on the evolving, perceptible difference between desired and actual position variables. The model explains the observed trajectories of VP and PTP movements as emergent properties of a dynamical system that does not precompute entire trajectories before movement initiation. The new model includes a working memory and a stage sensitive to time-to-contact information. These cooperate to control serial performance. The structural and functional relationships proposed in the model are consistent with available data on forebrain physiology and anatomy.Office of Naval Research (N00014-92-J-1309, N00014-93-1-1364, N0014-95-1-0409

Intimate partner violence during the COVID-19 pandemic in Western and Southern European countries

Background: Intimate partner violence (IPV) is a significant problem with several negative health outcomes. Disasters are linked to increased IPV, but little is known about reporting of and strategies to address IPV during the COVID-19 pandemic. This review maps the IPV reporting during the pandemic and interventions to prevent and respond to IPV in 11 Western and Southern European countries. Methods: Government websites, news articles and pre-prints were searched using the terms 'domestic violence' or 'violence' in combination with 'Covid' or 'Corona'. Embase, PubMed, Scopus and Google Scholar were searched using the terms 'domestic violence' and 'partner violence' and 'interventions'. Results: Six countries showed an increase in domestic violence reports (Austria, Belgium, France, Ireland, Spain and UK), two countries a drop (Italy and Portugal), two countries showed no change (The Netherlands and Switzerland) and one country did not provide comparative data (Germany). Common measures to address IPV were starting a campaign (nine countries), creating online support (seven), more funding for alternative accommodation (seven) and support (eight) and use of a code word (four). Conclusions: IPV reports or helpline calls in Western and Southern European countries in the first weeks of COVID-19 measures increased in six countries, remained the same in two countries and showed a decrease in two countries. While this review cannot ascertain the impact of the measures taken by the countries during the pandemic and beyond, this mapping provides a foundation for future research, and an opportunity to trace the efficacy of these strategies

Risk factors for COPD exacerbations in inhaled medication users: the COPDGene study biannual longitudinal follow-up prospective cohort.

BackgroundDespite inhaled medications that decrease exacerbation risk, some COPD patients experience frequent exacerbations. We determined prospective risk factors for exacerbations among subjects in the COPDGene Study taking inhaled medications.Methods2113 COPD subjects were categorized into four medication use patterns: triple therapy with tiotropium (TIO) plus long-acting beta-agonist/inhaled-corticosteroid (ICS ± LABA), tiotropium alone, ICS ± LABA, and short-acting bronchodilators. Self-reported exacerbations were recorded in telephone and web-based longitudinal follow-up surveys. Associations with exacerbations were determined within each medication group using four separate logistic regression models. A head-to-head analysis compared exacerbation risk among subjects using tiotropium vs. ICS ± LABA.ResultsIn separate logistic regression models, the presence of gastroesophageal reflux, female gender, and higher scores on the St. George's Respiratory Questionnaire were significant predictors of exacerbator status within multiple medication groups (reflux: OR 1.62-2.75; female gender: OR 1.53 - OR 1.90; SGRQ: OR 1.02-1.03). Subjects taking either ICS ± LABA or tiotropium had similar baseline characteristics, allowing comparison between these two groups. In the head-to-head comparison, tiotropium users showed a trend towards lower rates of exacerbations (OR = 0.69 [95 % CI 0.45, 1.06], p = 0.09) compared with ICS ± LABA users, especially in subjects without comorbid asthma (OR = 0.56 [95% CI 0.31, 1.00], p = 0.05).ConclusionsEach common COPD medication usage group showed unique risk factor patterns associated with increased risk of exacerbations, which may help clinicians identify subjects at risk. Compared to similar subjects using ICS ± LABA, those taking tiotropium showed a trend towards reduced exacerbation risk, especially in subjects without asthma.Trial registrationClinicalTrials.gov NCT00608764, first received 1/28/2008

Ferromagnetic Domain Structure of La0.78Ca0.22MnO3 Single Crystals

The magneto-optical technique has been employed to observe spontaneous ferromagnetic domain structures in La0.78Ca0.22MnO3 single crystals. The magnetic domain topology was found to be correlated with the intrinsic twin structure of the investigated crystals. With decreasing temperature the regular network of ferromagnetic domains undergoes significant changes resulting in apparent rotation of the domain walls in the temperature range of 70-150 K. The apparent rotation of the domain walls can be understood in terms of the Jahn-Teller deformation of the orthorhombic unit cell, accompanied by additional twinning.Comment: 7 pages, 5 figures, to be published in PR

Українська шляхта між польським та українським етносами

Appearance and existence of the Ukrainian gentry relates to the traditions of Polish political culture, so during the whole period of its life it was between the Ukrainian and the Polish ethnic groups. Polanisation of the Ukrainian gentry begins at the date when some of the Ukrainian territories become a part of Poland and strengthens after Cossack revolution in the middle and at the end of the 16th century. Especially this process becomes effective at the beginning of the 18th century when a great part of gentry from other Polish lands migrates to Pravoberezhia (right-banked Ukraine). Nevertheless, having captured upper class and partially middle class of the Ukrainian gentry, polanisation mainly influenced consciousness and less religion of the lower class of the Ukrainian gentry. As for ethnoculture and language local gentry was mostly Ukrainian and it assimilated numerous Polish gentlemen-immigrants

Vortex Solid-Liquid Transition in Bi2_{2}Sr2_{2}CaCu2_{2}O8+δ_{8+\delta} with a High Density of Strong Pins

The introduction of a large density of columnar defects in %underdoped Bi$_{2}$Sr$_{2}$CaCu$_{2}$O$_{8+\delta}$ crystals does not, at sufficiently low vortex densities, increase the irreversibility line beyond the first order transition (FOT) field of pristine crystals. At such low fields, the flux line wandering length $r_{w}$ behaves as in pristine %Bi$_{2}$Sr$_{2}$CaCu$_{2}$O$_{8+\delta}$ crystals. Next, vortex positional correlations along the $c$--axis in the vortex Bose glass at fields above the FOT are smaller than in the low--field vortex solid. Third, the Bose-glass-to-vortex liquid transition is signaled by a rapid decrease in c-axis phase correlations. These observations are understood in terms of the ``discrete superconductor'' model.Comment: 4 pages, 4 figures Submitted to Phys. Rev. B Rapid Comm. 16-1-2004 Revised version 18-3-200